Postmenopausal osteoporosis and breast cancer: The biochemical links and beneficial effects of functional foods

Muhammad, Aliyu; Mada, Sanusi Bello; Malami, Ibrahim; Forcados, Gilead Ebiegberi; Erukainure, Ochuko L.; Sani, Hadiza; Abubakar, Ibrahim Babangida

doi:10.1016/j.biopha.2018.08.018

Cited by 36 publications

(22 citation statements)

References 178 publications

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“…C. arietinum sprouts, especially after fermentation with Lactobacillus casei , could be considered as a dietary component of functional and little-processed food able to prevent the loss of bone mass induced by the chronic inflammation connected with obesity. Furthermore, a diet rich in phytoestrogens (especially soy isoflavones) has been documented as preventive for postmenopausal osteoporosis and breast cancer [ 17 , 47 ]. In this regard, it was shown that biochanin A, one of the components of C. arietinum sprouts, may decrease osteoclast activation, osteoporosis and mammary carcinogenesis via interaction with RANKL [ 29 , 44 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Cicer arietinum L. Sprouts’ Influence on Mineralization of Saos-2 and Migration of MCF-7 Cells

et al. 2020

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In the present study, we investigated the biological activity of four extracts obtained from Cicer arietinum L. sprouts. The fermentation of the sprouts with Lactobacillus casei and their incubation with β-glucosidase elevated the concentrations of isoflavonoids, especially coumestrol, formononetin and biochanin A. To study the biological activity of C. arietinum, the human osteosarcoma Saos-2 and human breast cancer MCF-7 cell lines were used. The extracts obtained from fermented sprouts exhibited the strongest ability to decrease intracellular oxidative stress in both types of cells. They augmented mineralization and alkaline phosphatase activity in Saos-2 cells, as well as diminished the secretion of interleukin-6 and tumor necrosis factor α. Simultaneously, the extracts, at the same doses, inhibited the migration of MCF-7 cells. On the other hand, elevated concentrations of C. arietinum induced apoptosis in estrogen-dependent MCF-7 cells, while lower doses stimulated cell proliferation. These results are important for carefully considering the use of fermented C. arietinum sprouts as a dietary supplement component for the prevention of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Cicer arietinum L. Sprouts’ Influence on Mineralization of Saos-2 and Migration of MCF-7 Cells

et al. 2020

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“…Apart from providing nutrients and energy, functional foods also modulate the body’s physiological functions ( Nicoletti, 2012 ). The potentially numerous health benefits of functional foods to humans have been explored ( Muhammad et al, 2018 ). Among the several important beneficial effects of functional foods include their potential to prevent and treat COVID-19.…”

Section: Introductionmentioning

confidence: 99%

“…Omega-3 FA, fixed oils, oils obtained from nuts, coconut, soy, sesame, and fruits are common sources of naturally occurring FA. Omega-3 FA are a class of polyunsaturated fatty acids (PUFA) that are known to have beneficial effects in the prevention and management of various diseases ( Muhammad et al, 2018 ). The two major biologically active types of omega-3 FA are eicosapentaenoic acid and docosahexaenoic acid (DHA) ( Daak et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies

et al. 2021

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The 2019 coronavirus disease (COVID-19) is a potentially fatal multisystemic infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently, viable therapeutic options that are cost effective, safe and readily available are desired, but lacking. Nevertheless, the pandemic is noticeably of lesser burden in African and Asian regions, where the use of traditional herbs predominates, with such relationship warranting a closer look at ethnomedicine. From a molecular viewpoint, the interaction of SARS-CoV-2 with angiotensin converting enzyme 2 (ACE2) is the crucial first phase of COVID-19 pathogenesis. Here, we review plants with medicinal properties which may be implicated in mitigation of viral invasion either via direct or indirect modulation of ACE2 activity to ameliorate COVID-19. Selected ethnomedicinal plants containing bioactive compounds which may prevent and mitigate the fusion and entry of the SARS-CoV-2 by modulating ACE2-associated up and downstream events are highlighted. Through further experimentation, these plants could be supported for ethnobotanical use and the phytomedicinal ligands could be potentially developed into single or combined preventive therapeutics for COVID-19. This will benefit researchers actively looking for solutions from plant bioresources and help lessen the burden of COVID-19 across the globe.

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“…The main cause of osteoporosis is that bone resorption dominated by osteoclasts is greater than bone formation dominated by osteoblasts; that is, bone remodeling has a negative balance [ 4 , 5 ]. Osteoporosis is currently mainly divided into secondary osteoporosis and primary osteoporosis [ 6 , 7 ]. The etiology of secondary osteoporosis is relatively clear, mainly endocrine factors, nutritional factors, disuse factors, genetic factors, immune factors, drug factors, etc.…”

Section: Introductionmentioning

confidence: 99%

“…[6]. e onset of primary osteoporosis is related to heredity, aging, hormone levels, immunity, environmental factors, and nutritional status [7,8]. According to the pathogenesis of osteoporosis, the current treatment needs to be combined with lifestyle adjustment, bone health supplement addition, drug intervention, and rehabilitation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Improving Effect and Safety of Probiotic Supplements on Patients with Osteoporosis and Osteopenia: A Systematic Review and Meta-Analysis of 10 Randomized Controlled Trials

Zeng

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Aim. Probiotics are considered to be bone metabolism regulators, and their efficacy as an adjuvant treatment option for osteoporosis is still controversial. The purpose of this study is to compare the available data from randomized controlled trials (RCT) of probiotics in the treatment of osteoporosis and osteopenia. Methods. As of June 2021, databases such as Medline, Embase, Web of Science, and Central Cochrane Library have been used for English-language literature searches and CNKI and China Biomedical Database have been used for Chinese-language literature searches. RevMan 5.3 was used for bias risk assessment, heterogeneity detection, and meta-analysis. This research has been registered in PROSPERO (CRD42020085934). Results. This systematic review and meta-analysis included 10 RCTs involving 1156. Compared with the placebo, the absolute value of lumbar spine’s BMD was not statistically significant (WMD 0.04 (−0.00, 0.09), P = 0.07 , random effect model), while the percentage of lumbar spine’s BMD was higher (SMD 1.16 (0.21, 2.12), P = 0.02 , random effect model). Compared with the control group, the percentage of total hip’s BMD was not statistically significant (SMD 0.52 (−0.69, 1.73), P = 0.40 , random effect model). The safety analysis showed that, compared with control group, the adverse events in the experimental group were not statistically significant (RR 1.02 (0.92, 1.12), P = 0.70 , fixed effect model). Conclusion. Probiotics may be safety supplements to improve the lumbar spine’s BMD of patients with osteoporosis and osteopenia. More large-sample, random-controlled, high-quality RCTs are needed to further verify the effectiveness and safety of probiotics in intervening osteoporosis or osteopenia.

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Postmenopausal osteoporosis and breast cancer: The biochemical links and beneficial effects of functional foods

Cited by 36 publications

References 178 publications

Cicer arietinum L. Sprouts’ Influence on Mineralization of Saos-2 and Migration of MCF-7 Cells

Cicer arietinum L. Sprouts’ Influence on Mineralization of Saos-2 and Migration of MCF-7 Cells

Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies

The Improving Effect and Safety of Probiotic Supplements on Patients with Osteoporosis and Osteopenia: A Systematic Review and Meta-Analysis of 10 Randomized Controlled Trials

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