Postmortale Bildgebung der Lunge bei COVID-19-Todesfällen

Kniep, Inga; Lutter, Marcus; Ron, Alexandra; Edler, C.; Püschel, Klaus; Ittrich, Harald; Heller, Martin; Heinemann, Axel

doi:10.1007/s00117-020-00733-y

Cited by 14 publications

(16 citation statements)

References 25 publications

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“…In the postmortem computed tomography, ground glass opacities and reticular changes of both lungs have been described as being COVID-19-associated lung changes [29]. These are also the radiological characteristics that we were able to identify in this case.…”

Section: Discussionsupporting

confidence: 65%

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Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variant

et al. 2021

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The current pandemic with Severe acute respiratory syndrome-coronavirus-2 has been taking on new dynamics since the emergence of new variants last fall, some of them spreading more rapidly. Many countries currently find themselves in a race to ramp up vaccination strategies that have been initiated and a possible third wave of the pandemic from new variants, such as the Variant of Concern-202012/01 from the B.1.1.7 lineage. Until today, many investigations in death cases of Coronavirus-disease-19 have been conducted, revealing pulmonary damage to be the predominant feature of the disease. Thereby, different degrees of macroscopic and microscopic lung damage have been reported, most of them resembling an Acute Respiratory Distress Syndrome. Far more, systemic complications of the disease such as pulmonary embolisms have been described. However, neither morphologic nor virologic findings of patients dying of the new variants have yet been reported. Here, we report on a comprehensive analysis of radiologic, morphologic, and virologic findings in a fatal case of this variant.

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Section: Discussionsupporting

confidence: 65%

“…These are also the radiological characteristics that we were able to identify in this case. However, the observed radiologic findings are reported to be not disease-specific [29]. Apart from previously described changes in the literature, no other pulmonary radiologic features were observed [29].…”

Section: Discussionmentioning

confidence: 49%

Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variant

et al. 2021

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“…described GGO and localized consolidation [ 10 ], comparable to the illustrative case series reported here. The authors own recent study of SARS-CoV-2-associated deaths from Hamburg, Germany and with post-mortem imaging also showed these typical patterns: GGO, consolidations and crazy-paving patterns [ 9 , 14 ]. Even in the very first COVID-19 deceased in Hamburg, GGO and reticular changes in the PMCT were already diagnosed as being disease-associated lung changes [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, pulmonary artery embolisms diagnosed at autopsy [ 5 ] in a relevant percentage of COVID-19 deaths could not be reliably delineated in the native PMCT [ 9 ]. To the best of our knowledge no systematic studies have yet investigated the possible benefit of PMCT angiography to overcome this issue.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison to clinical CT, the assessment of lung tissue in PMCT, especially in the dorsal segments, where fluid accumulation typically occurs, may be complicated by post-mortem artifacts in the lungs caused by hypostasis. Furthermore, post-mortem increases in pleural effusions may mask dorsal findings [ 9 ]. Dorsal hypostasis, which is typically manifested as milk glass opacity [ 2 ], increases with time after death [ 6 ] highlighting the necessity of fast post-mortem imaging after death, whenever possible.…”

Section: Difficulties Of Lung Interpretation In Pmctmentioning

confidence: 99%

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COVID-19 lungs in post-mortem computed tomography

et al. 2021

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Post-mortem computed tomography (PMCT) is a rapid and noninvasive diagnostic tool for important contributions to the identification of pulmonary findings in the deceased with pneumonia, including cases of coronavirus disease 2019 (COVID-19). Although computed tomography (CT) shows a high sensitivity for pneumonia in living persons, it is relatively unspecific for COVID-19 pneumonia clinically. Typical CT findings for viral pneumonia therefore require confirmation by PCR tests (polymerase chain reaction tests), even if lung infections with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) show characteristic patterns, most frequently ground glass opacities (GGO) and a combination of GGO and air space consolidations. In the consecutive autopsy series of SARS-CoV‑2 deaths from Hamburg, Germany, the most frequent cause of death was and still is COVID-19 pneumonia. Typical findings were frequently found in the PMCT in SARS-CoV-2-associated deaths, which were taken into account when classifying the death as COVID-19.

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Plötzliche und unerwartete Todesfälle: Allgemeine Aspekte

Püschel

2023

Rechtsmedizin

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Postmortale Bildgebung der Lunge bei COVID-19-Todesfällen

Cited by 14 publications

References 25 publications

Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variant

Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variant

COVID-19 lungs in post-mortem computed tomography

Plötzliche und unerwartete Todesfälle: Allgemeine Aspekte

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