Postmortem Body and Organ Measurements in Neonates and Infants

Evetts, Audrey-Ann M; Shkrum, Michael J.; Tugaleva, Elena

doi:10.1097/paf.0000000000000258

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…The mean weight of liver was found in neonates to be (108.366 ±32.11 gram) with statistically highly significant relation between livers weight and age. Mirzaali o'g'li AJ et al (16) , which demonstrated that the weight of the liver in the neonates is on average 135 g. (17) & Evetts A-AM (18) these studies proved that the livers weight in the same ages was respectively 124.52 ± 0.425, 146.51 ± 38.65 gram.…”

Section: Discussionmentioning

confidence: 88%

Anatomical and Morphometric Parameters Study of Human Neonatal Liver in Kirkuk City

Abdullah,

Mohammed,

Mahmood

2023

KJMS

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 Background: The liver, situated in the upper right abdomen, is vital for detoxification, protein synthesis, bile production, and nutrient storage. This study aims to investigate the anatomical and morphometric characteristics of neonatal livers in Kirkuk city. Methods: Between November 2022 and June 2023, an autopsy of 31 cadavers (aged 1-28 days, 40-55 cm in length, 2.9-5.4 kg) was performed in Kirkuk governorates. After cleaning with tap water, the bodies were placed supine with an elevated chest. A longitudinal midline thoracoabdominal incision allowed examination of the liver's anatomical position and surrounding structures. Result: The neonatal liver displayed a rubbery, solid consistency and had a reddish-brown color. It occupied the upper portion of the abdominal cavity in the right hypochondrium. Anatomically, it consisted of the right and left lobes, with small caudate and quadrate lobes present in the right lobe. The right lobe constituted approximately half to two-thirds of the total liver volume. Gross inspection revealed that the left lobe was smaller and more flattened compared to the right lobe. Its upper surface was slightly convex and conformed to the diaphragm. The weight of the neonatal liver was 108.366 ±32.11 grams, with maximum dimensions of 4.85-6.45 cm in height and 5.7-7.8 cm in length. The transverse and anteroposterior dimensions of the right and left lobes measured (5.72, 3.15, 3.57, 2.93 cm) respectively. Conclusions: This study offers evidence on the anatomical features, location, shape, weight, and morphometric parameters of the neonatal liver, utilizing caliper measurements to provide dependable estimates of normal liver volume. It may serve as a valuable reference for future research endeavors.

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Section: Discussionmentioning

confidence: 88%

Anatomical and Morphometric Parameters Study of Human Neonatal Liver in Kirkuk City

Abdullah,

Mohammed,

Mahmood

2023

KJMS

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“…For the initial design, anthropometric references of the esophagus, the azygos vein, and the trachea were taken from different bibliographic references [16,17], and a preliminary range of measures and diameters was established. Autodesk Fusion 360 ® (Autodesk, CA., USA) was used to design a first topographic composition of the model and to establish an approximate proportional relationship between the different elements that integrated it.…”

Section: Methodsmentioning

confidence: 99%

Development and validation of a realistic type III esophageal atresia simulator for the training of pediatric surgeons

Montero,

Pérez Riveros,

Bueso Asfura

et al. 2024

Preprint

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Background: The technical complexity and limited casuistry of neonatal surgical pathology limit the possibilities of developing the necessary technical competencies by specialists in training. Esophageal atresia constitutes the paradigm of this problem. The use of 3D models for training is a promising line of research, although the literature is limited. Methods: We conceptualized, designed, and produced an anatomically realistic model for the open correction of type III oesophageal atresia. We validated it with two groups of participants (experts and non-experts) through face, construct, and content validity questionnaires. Results: The model was validated by 9 experts and 9 non-experts. The mean procedure time for the experts and non-experts groups was 34.0 and 38.4 minutes respectively. Two non-experts did not complete the procedure at the designed time (45 minutes). Regarding the face validity questionnaire, the mean rating of the model was 3.2 out of 4. Regarding the construct validity, we found statistically significant differences between groups for the equidistance between sutures, 100% correct in the expert group vs. 42.9% correct in the non-expert group (p=0.02), and for the item: Confirms that tracheoesophageal fistula closure is watertight before continuing the procedure, correctly assessed by 66.7% of the experts vs. by 11.1% of non-experts (p=0.05). Concerning content validity, the mean score was 3.3 out of 4 for the experts and 3.3 out of 4 for the non-experts (p=0.32). Conclusions: The present model is a cost-effective, simple to produce, and validated option for the training of open correction of type III oesophageal atresia. Future studies with larger sample sizes and blinded validators are needed before drawing definitive conclusions.

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“…It follows obviously from the analysis of short postnatal period. During 1.2 -1.3 months of life, the wet weight of thymus (TWW) increases 4-fold, and average mass of the body (MB), heart, lung, kidney, liver, spleen, pancreas, brain increase 2.34 ± 0.35-fold also [33]. A TWW during children's growth spurt (from 2.5 to 13 years old), continues to increase 1.4-fold (from 25 to 36 g), in parallel with 2,1-fold increasing the average rate of MB, with rate (MBR) from +2.3 kg per year to +5 kg per year) (Figure 3).…”

Section: Thymusmentioning

confidence: 99%

“…[33] [99] [100][101] [102][103]. Conversely, lymphocyte number decreases to the normal level of adults at 18 and continues to drop up to death, along with the slow involution of a fat-free mass of the body[33] [99].…”

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confidence: 99%

Time for a New Paradigm in Oncology? Viewpoint of the Radiobiologist

Shoutko

2024

OJBIPHY

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The current immunooncology artificially ignores the connection with lymphopoiesis, though is only its derivative. Hematopoietic stem cells (HSC) provide physiological regeneration of biomass of the host, fetus, and malignant tumors, as well, as the cells' reparation after sub-lethally injuring in any tissues and their renewal. HSC, especially of lymphoid lineage, are the most vulnerable of those, which are responsible for viability of organism. Natural and artificial deficits of HSC determine aging, multi-organs syndromes and death of the host, because their current proliferative resource (CPR) is individually limited at birth, and is spending irreversibly during wounds' healing, pregnancy, tumor growth, and on. CPR, being an integral value of the number of stem cells along the length of their telomeres, is a "shagreen skin", for which the tumor competes with normal tissues as a quasi-embryonic favorite and winner, especially in the final period of a shortening the life. The primary approach to cancer treatment must prioritize the preservation of CPR remnants, rather than their destruction, in order to temporarily halt the malignant process. The re-targeting of HSC from tumors in favor of normal tissues is the immediate objective of competitive therapy, which allows for preserving the rest of the CPR host's resources, especially in patients with advanced cancer. However, the contradictory and insignificant practically, the dogma of antitumor cellular immunity continues to dominate and hinder progress in oncology.

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Postmortem Body and Organ Measurements in Neonates and Infants

Cited by 9 publications

References 7 publications

Anatomical and Morphometric Parameters Study of Human Neonatal Liver in Kirkuk City

Anatomical and Morphometric Parameters Study of Human Neonatal Liver in Kirkuk City

Development and validation of a realistic type III esophageal atresia simulator for the training of pediatric surgeons

Time for a New Paradigm in Oncology? Viewpoint of the Radiobiologist

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