Postmortem Changes in the Vestibular and Cochlear Receptors (Guinea Pig)

Fernández, Ceneida

doi:10.1001/archotol.1958.00730020480009

Cited by 36 publications

(5 citation statements)

References 6 publications

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“…In 48 (40.7%) temporal bones, Reissner's membrane was retracted similar to that described by Fernandez [17] and Fraysse et al [13], In 21 (32.8%), retraction was found beside bulging in different turns of the same tempo ral bone. Compared to the high incidence of bulging in the cochlear duct, fewer saccules and utricles were dilated and in these the incidence was slightly higher in saccules (42.4%; table 4).…”

Section: Resultssupporting

confidence: 79%

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Endolymphatic Hydrops in Children

Bachor

Karmody

1995

ORL

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Apart from clinical observations of Ménière’s disease in children, there have only been a few histological descriptions of endolymphatic hydrops (EH) as an incidental finding in children. In this paper we report on the incidence of EH in temporal bones of children. One hundred eighteen temporal bones from 70 infants between newborn and 10 years (average age 12.9 months) were analyzed by light microscopy for EH of the cochlear duct, which was defined as a bulging of Reissner’s membrane into the scala vestibuli in more than one turn of the cochlea. All endolymph spaces were carefully examined for factors such as an obliterated ductus reuniens which may have contributed to the development of EH. In 64 (54.2%) of the 118 temporal bones, a bulging of Reissner’s membrane in the cochlear duct was found. In 65.6%, the bulging was confined to the apical turn and since the significance of isolated apical hydrops is controversial, we elected not to consider this group as having hydrops. Twenty (16.9%) bones met our criteria for a diagnosis of EH. Compared to the high incidence of bulging in the cochlear duct, fewer saccules and utricles were dilated. In approximately half of the temporal bones (49.2%), the ductus reuniens was collapsed. The ductus reuniens seems to be closed in its normal position and might open when pressure occurs due to an increasing volume of endolymph. If there is a permanent closure, EH may result. Our investigation does not indicate that EH is associated with a specific disease; however, where there were congenital anomalies the incidence of EH was higher. The endolymph system seems to be sensitive to external disturbances, and EH is possibly related to many kinds of metabolic disorders of early infancy.

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Section: Resultssupporting

confidence: 79%

“…In this unstable situation it is conceivable that, due to various metabolic processes, the infant temporal bone is particularly vul nerable to the development of EH. For example in a study on guinea pigs, Fernandez [ 17] related the position of Reissner's membrane to the metabolic state of the stria.…”

Section: Discussionmentioning

confidence: 99%

Endolymphatic Hydrops in Children

Bachor

Karmody

1995

ORL

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“…Autolytic changes within the inner ear between death and fixation have been documented previously (16,17,19). However, those studies were primarily concerned with changes in the cells in and around the sensory regions of the inner ear and less concerned with changes in the cells of the enveloping membranes.…”

Section: Discussionmentioning

confidence: 94%

“…Of necessity, fixation was by immersion of the whole temporal bone in fixative which is acknowledged to be an inferior way of fixing the human inner ear (16)(17)(18)(19). Two procedures were used to try to overcome this problem and to ensure adequate fixation.…”

Section: Discussionmentioning

confidence: 99%

Dimensions of the Horizontal Semicircular Duct, Ampulla and Utricle in the Human

Curthoys

Oman

1987

Acta Oto-Laryngologica

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This study provides measurements in individual specimens of the sizes, cross-sectional shapes and areas all around the path of fluid flow through the human horizontal semicircular duct, ampulla and utricle. These data were obtained from multiple measurements on individual specimens which had been fixed by immersion in Karnovsky's fixative and microdissected. The results are compared with similar measurements in the rat and guinea pig.

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“…Much work has been done utilizing the cochlea of the inner ear (23,79,93,94) and the external ear as an experimental model for studies of otitis externa in humans. The clinical appearance of the diseased canal is very similar to that in man (105).…”

Section: Nutritional Researchmentioning

confidence: 99%

Selected Topics in Laboratory Animal Medicine. Volume 22. The Guinea Pig

Obeck¹

1974

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Postmortem Changes in the Vestibular and Cochlear Receptors (Guinea Pig)

Cited by 36 publications

References 6 publications

Endolymphatic Hydrops in Children

Endolymphatic Hydrops in Children

Dimensions of the Horizontal Semicircular Duct, Ampulla and Utricle in the Human

Selected Topics in Laboratory Animal Medicine. Volume 22. The Guinea Pig

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