Postmortem serotonin levels in cerebrospinal and pericardial fluids with regard to the cause of death in medicolegal autopsy

Quan, Li; Ishikawa, Takaki; Hara, Junpei; Michiue, Tomomi; Chen, Jianhua; Wang, Qi; Zhu, Bao‐Li; Maeda, Hitoshi

doi:10.1016/j.legalmed.2010.11.003

Cited by 21 publications

(16 citation statements)

References 39 publications

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“…Pericardial fluid has been used in forensic practice for several applications to measure different markers, including glucose, ketone bodies, calcium, sodium, potassium, magnesium, urea nitrogen, creatinine, uric acid, markers of myocardial ischemia and cardiac function, insulin, C-peptide and serotonin [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. Pericardial fluid levels have been found to be as reliable as blood levels for some of these parameters, thus suggesting that this substrate could be used for postmortem analyses when postmortem biochemical investigations are required to circumstantiate the pathogenesis of death and sufficient amounts of blood are unavailable.…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

et al. 2012

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The aim of this study was to investigate the presence and concentrations of procalcitonin and C-reactive protein in pericardial fluid and compare these levels to those found in the postmortem serum obtained from the femoral blood. Two groups were formed, a sepsis-related fatalities group and a control group. Postmortem native CT scans, autopsies, histology, neuropathology and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Pericardial fluid procalcitonin levels were significantly different between the cases of sepsis-related fatalities and those of the control group. Postmortem serum procalcitonin levels below the detection limit were also reflected in undetectable pericardial fluid levels. Similarly, a large increase in postmortem serum procalcitonin levels was reflected in a large increase of procalcitonin pericardial fluid levels. Based on these findings, pericardial fluid could be an alternative to postmortem serum for the determination of procalcitonin levels in cases where postmortem serum is not available and measurements of procalcitonin are required to circumstantiate the pathogenesis of death

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Section: Introductionmentioning

confidence: 99%

Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

et al. 2012

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“…Yoshida et al [39] Right heart blood postmortem serum and CSF Lower serum and higher CSF CgA levels Lower serum adrenaline and noradrenaline levels CSF CgA levels higher then serum levels Serotonin Quan et al [73] CSF and PF Low serotonin levels in both fluids S100B…”

Section: Discussionmentioning

confidence: 99%

“…Since hypothermia cases tended to display low hypothalamus neuronal CgA immunopositivity with a positive correlation to CSF CgA levels, the authors postulated that there was a terminal state of hypothalamus dysfunction involving the depletion of CgA-containing secretory granules in prolonged death due to cold exposure. Quan et al [73] investigated serotonin (5-HT) levels in cerebrospinal and pericardial fluids regarding the cause of death in 351 medicolegal autopsy cases. They found that the hypothermia cases tended to have low 5-HT levels in both fluids and postulated the usefulness of this marker for investigating hypothermia as the cause of death in the absence of morphological evidence.…”

Section: Isopropyl Alcoholmentioning

confidence: 99%

Postmortem biochemical investigations in hypothermia fatalities

Palmière

Mangin

2012

Int J Legal Med

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Despite the progress made during the past several decades in forensic pathology, the possibilities for the postmortem diagnosis of hypothermia remains relatively limited. Aside from histology and immunohistochemistry, numerous authors have investigated the postmortem biochemistry of hypothermia fatalities. Several biochemical markers (e.g., glucose, electrolytes, hormones, ketone bodies, and neurotransmitters) and various biological samples (e.g., blood, urine, heart, liver, skeletal muscle as well as pericardial and cerebrospinal fluids) have been proposed as potentially useful markers to improve the insufficient diagnostic efficacy of macroscopic and microscopic findings. The aim of this article is to review the medicolegal literature covering the postmortem biochemical investigations that are associated with hypothermia cases as well as report our own research results on this topic where possible.

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“…Quan et al [150] investigated serotonin (5-HT) levels in cerebrospinal and pericardial fluids with regard to the cause of death in 351 medico-legal autopsy cases. The postmortem 5-HT concentration in cerebrospinal fluid was similar to that described in a previous study carried out by Musshoff et al [151] and higher than the clinical reference value, whereas the postmortem 5-HT level in pericardial fluid overlapped with the clinical serum level.…”

Section: Serotoninmentioning

confidence: 99%

Postmortem chemistry update part II

Palmière

Mangin

2011

Int J Legal Med

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As a continuation of "Postmortem Chemistry Update Part I," Part II deals with molecules linked to liver and cardiac functions, alcohol intake and alcohol misuse, myocardial ischemia, inflammation, sepsis, anaphylaxis, and hormonal disturbances. A very important array of new material concerning these situations had appeared in the forensic literature over the last two decades. Some molecules, such as procalcitonin and C-reactive protein, are currently researched in cases of suspected sepsis and inflammation, whereas many other analytes are not integrated into routine casework. As in part I, a literature review concerning a large panel of molecules of forensic interest is presented, as well as the results of our own observations, where possible.

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Postmortem serotonin levels in cerebrospinal and pericardial fluids with regard to the cause of death in medicolegal autopsy

Cited by 21 publications

References 39 publications

Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

Postmortem biochemical investigations in hypothermia fatalities

Postmortem chemistry update part II

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