Postmortem urinary catecholamine levels with regard to the cause of death

Ishikawa, Takaki; Inamori-Kawamoto, Osamu; Quan, Li; Michiue, Tomomi; Chen, Jianhua; Wang, Qi; Zhu, Bao‐Li; Maeda, Hitoshi

doi:10.1016/j.legalmed.2014.07.006

Cited by 23 publications

(17 citation statements)

References 41 publications

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“…Adrenaline and noradrenaline are derived from metabolic modification of dopamine, which partially could explain the variation observed in blood dopamine levels in the present study. Catecholamine levels in the blood, cerebrospinal fl uid, pericardial fl uid, and urine, as for the secretion of dopamine, were unstable in our previous postmortem human studies 23,38,39) . Western blotting using autopsy samples did not correlate with the results of mRNA examination, so the immunohistochemical examination gave clearer results.…”

Section: Discussionmentioning

confidence: 79%

Role of Circadian Clock Genes in Sudden Cardiac Death: A Pilot Study

Tani

Ikeda

Oritani

et al. 2017

J. Hard Tissue Biology.

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The present study deals with the circadian expression of clock genes in acute cardiac death to examine any correlation between clock gene expression and catecholamines. A total of 36 subjects, who died of acute ischemic heart disease (AIHD, n = 10), acute myocardial infarction (AMI, n = 11), and recurrent myocardial infarction (RMI, n = 15) and underwent autopsy within 2 days after death, were included in this study. The mRNA expression levels of the clock genes BMAL1, PER2, and REV-ERBα were determined in the post-mortem heart tissue. Catecholamine levels in blood obtained from the right heart were measured. Furthermore, the cellular localization of clock proteins was assessed by immunohistochemistry, and protein levels in the heart tissue were also measured by Western blotting. In our cases of AIHD death, BMAL1 and PER2 exhibited trimodal expression patterns; however, the trimodal expression pattern of PER2 was antiphasic to that of BMAL1. PER2 expression correlated with adrenaline and noradrenaline levels. In deaths from AMI, BMAL1 and PER2 exhibited antiphasic trimodal and bimodal expressions, respectively, and BMAL1 expression correlated with adrenaline and noradrenaline levels. In RMI, both BMAL1 and PER2 exhibited antiphasic unimodal expression patterns, which were not correlated with adrenaline and noradrenaline levels. REV-ERBα expression varied, and no correlations were found between dopamine levels and clock gene expression in any group. We concluded that catecholamine levels are decreased in AIHD and raised in AMI as a function of BMAL1 expression and that BMAL1 and PER2 modulate and suppress catecholamine levels respectively.

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Section: Discussionmentioning

confidence: 79%

Role of Circadian Clock Genes in Sudden Cardiac Death: A Pilot Study

Tani

Ikeda

Oritani

et al. 2017

J. Hard Tissue Biology.

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“…The Kruskal-Wallis and Mann-Whitney U test were used for non-parametric multiple and two-group comparisons among the sex of subjects, respectively [7]. The comparisons of measured values between histopathological findings were evaluated with unpaired t-test analysis.…”

Section: Discussionmentioning

confidence: 99%

Postmortem histopathological examination of changes due to systemic ischemia/hypoxia in the thyroid gland

Ikeda¹,

Tani²,

Michiue³

et al. 2017

Forensic Sci Criminol

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We investigated histopathological analysis of changes caused by systemic ischemia/hypoxia in the thyroid gland owing to acute mechanical asphyxia by neck compression or blunt head injury and compared the changes with those due to other types of deaths, including drowning and sudden cardiac death. A total of 96 forensic autopsies cases (64 males and 32 females) performed at our institute were examined; the age range and postmortem interval of these cases were 25-96 years (median, 67 years) and 12-72 h (median, 24 h), respectively. Cause of death in these cases were asphyxia (n = 21; hanging, n = 8; strangulation, n = 6; and others, n = 7), blunt injury (n = 17; acute/subacute head injury, n = 11; acute/subacute non-head injury, n = 6), sharp instrument injury (n = 6), drowning (n = 9; excluding drowning in the bathtub), fire fatalities [n = 37; carbon monoxide hemoglobin (CO-Hb) level < 30%, n =10; CO-Hb level = 30-60%, n = 16; CO-Hblevel > 60%, n =11], and acute myocardial infarction/ischemia (n = 6), without medical intervention. Serial horizontal sections of formalin-fixed, paraffin-embedded thyroid tissue specimens were prepared for hematoxylin-eosin (HE) and Azan staining for examining follicular destruction,follicular and epithelial cell vacuolation, follicular crystallization, parenchymatous hemorrhage, follicular size, and follicular metachromasia. Follicular destruction was more frequently detected in cause of death due to asphyxia and acute head injury than in those due to other causes. There were no significant differences among the subgroups of asphyxiation. Blood thyroid hormone levels were similar as those previous reported; however, they showed no relationship with follicular destruction. Other histological changes were independent of the cause of death.These findings suggest that thyroid follicular destruction points to systemic ischemia/hypoxia rather than mechanical injury to the neck.

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“…It has been speculated that the concomitant determination of catecholamine levels in different postmortem specimens could help semi-quantify stress intensity and the role of stress reactions in the pathogenesis of death. In addition, it has been postulated that high noradrenaline levels in cerebrospinal fluid or vitreous humor would be especially indicative of antemortem protracted stress [18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%