Postmortem vitreous humor β-hydroxybutyrate: its utility for the postmortem interpretation of diabetes mellitus

Osuna, Eduardo; Vivero, Guillermo; Conejero, J. Alberto; Abenza, José M.; Martínez, P.; Luna, A.; Pérez-Cárceles, María D.

doi:10.1016/j.forsciint.2004.09.105

Cited by 60 publications

(48 citation statements)

References 34 publications

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Section: Glucose and Ketonesmentioning

confidence: 99%

“…During ketoacidosis, BHB is found in the highest concentrations and seems to be the most specific post-mortem marker of ketoacidosis [5,8,[67][68][69]. Therefore, BHB has been well studied in VH [6,8,69]. Blood BHB and vitreous BHB show good correlation, and vitreous BHB is an attractive alternative when blood BHB is not used in post-mortem analysis [6,8,[69][70][71].…”

Section: Glucose and Ketonesmentioning

confidence: 99%

“…Therefore, BHB has been well studied in VH [6,8,69]. Blood BHB and vitreous BHB show good correlation, and vitreous BHB is an attractive alternative when blood BHB is not used in post-mortem analysis [6,8,[69][70][71]. The medical examiner is often faced with an elevated vitreous BHB that appears to have little or no bearing on the case [61].…”

Section: Glucose and Ketonesmentioning

confidence: 99%

“…The diagnosis of fatal metabolic complications in diabetes mellitus is difficult because of the lack of autopsy and histological findings. Moreover, these complications can occur in persons with no known diabetes [8].…”

Section: Glucose and Ketonesmentioning

confidence: 99%

“…It contains 99% water and solids in the form of macromolecular and low molecular weight constituents, such as sugars, urea, creatinine, and electrolytes. The various electrolytes that can be measured in VH include sodium, potassium, chloride, calcium, and magnesium [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Vitreous Humor: A Short Review on Post-mortem Applications

J¹

2015

J Clin Exp Pathol

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Vitreous humor has been investigated since the 1960s, with many debates occurring over the years with regard to the usefulness of its specific applications. The composition of several electrolytes in post-mortem vitreous humour has been extensively studied. Using the fluid for determining the cause of death has also become commonplace, including testing glucose levels of diabetic related deaths, as well as alcohol and drug related fatalities. The debate regarding the composition between two eyes of the same individual has been an issue in the past, but has since been resolved.

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