Postmovement Beta Synchronization in Patients With Parkinson's Disease

Pfurtscheller, Gert; Pichler-Zalaudek, Karin; Ortmayr, B.; Díez, José; Reisecker, F

doi:10.1097/00004691-199805000-00008

Cited by 68 publications

(42 citation statements)

References 32 publications

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“…The within-subject effects of expected uncertainty in the environment and of uncertainty in the feedforward estimate on different behavioral measurements and the PMBS, and the dependency of these effects on experimental conditions and execution order were assessed through multivariate mixed effects linear modeling using the "nlme" package (Pinheiro et al, 2008) in R (v 3.1-113). Multilevel linear modeling has the benefit of taking into account the dependency in data caused by repeated measurements within-subjects, and can identify within-subject relationships that are consistent across subjects, while treating the baseline differences across subjects as random effects (Aarts et al, 2014;Magezi, 2015).…”

Section: Methodsmentioning

confidence: 99%

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Post-Movement Beta Activity in Sensorimotor Cortex Indexes Confidence in the Estimations from Internal Models

2016

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Section: Methodsmentioning

confidence: 99%

“…Cortical PMBS is reduced in patients with Parkinson's disease (Pfurtscheller et al, 1998;Tamás et al, 2003). According to our proposed theory, an attenuation of the PMBS implies uncertainty in feedforward estimations and would engender more reliance on sensory feedback and a greater variability of movement.…”

Section: Implications For Diseasementioning

confidence: 99%

Post-Movement Beta Activity in Sensorimotor Cortex Indexes Confidence in the Estimations from Internal Models

2016

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“…In the gamma band, the peak over activation was located in BA 6 in the medial frontal gyrus, corresponding to the supplementary motor area (SMA), well known as a relevant area for PD (Carbon et al, 2007;Huang et al, 2007;Turner et al, 2003).The importance of beta/gamma activity for motor action in the EEG is well documented for healthy subjects (Neuper and Pfurtscheller, 2001;Svoboda et al, 2004) and also in PD patients (Brown and Marsden, 1999;Llinás et al, 1999;Pfurtscheller et al, 1998;Schnitzler and Gross, 2005;Timmermann et al, 2003).…”

Section: Cortical Generators Of Excess Eeg Powermentioning

confidence: 98%

Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients

et al. 2008

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(2008). Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients. NeuroImage, 41(3):985-997. Postprint available at: http://www.zora.uzh.ch Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients Abstract Oscillatory and coherent EEG activity is increasingly recognized as a fundamental hallmark of cortical integrative functions. We aimed to study deviations from the norm of different resting EEG parameters in Parkinson's disease (PD) patients. We compared spectral parameters of the resting EEG of PD patients (n=24, median age 67 years) to those of healthy controls (n=34, median age 62 years). On average, the patient group exhibited higher spectral power over the frequency range of 2-100 Hz, and the dominant peak was shifted towards lower frequencies. Maximal differences appeared in the 6-9 Hz theta band in all electrodes. Frontal electrodes contributed most to this difference in the 4-6 Hz theta, 12-18 Hz beta and 30-45 Hz gamma bands. On an individual basis, the combination of six spectral power band parameters discriminated between patient and control groups and 72% of all subjects were classified correctly. Using LORETA source analysis, the generators of this power difference were localized to fronto-insulo-temporal cortical areas in the theta and beta bands, and to interhemispheric frontal (supplementary motor area, SMA) and cingulate areas in the 30-45 Hz gamma band. We calculated spectral coherence between electrode pairs in a frontal, central and parietal region of interest (ROI). In the frontal ROI, coherence was enhanced significantly in the patient group in the theta, high beta and gamma bands. In the parietal ROI, patients showed lower coherence around 10 Hz. We demonstrate a deviation from the norm of different resting EEG parameters in PD patients. This evidence can be integrated in the context of a pathophysiological chain reaction initiated in the substantia nigra and resulting in a cortical aberrant dynamics rooted in enhanced dysrhythmic thalamocortical interactions.Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients Oscillatory and coherent EEG activity is increasingly recognized as a fundamental hallmark of cortical integrative functions. We aimed to study deviations from the norm of different resting EEG parameters in Parkinson's disease (PD) patients. We compared spectral parameters of the resting EEG of PD patients (n = 24, median age 67 years) to those of healthy controls (n = 34, median age 62 years).On average, the patient group exhibited higher spectral power over the frequency range of 2-100 Hz, and the dominant peak was shifted towards lower frequencies. Maximal differences appeared in the 6-9 Hz theta band in all electrodes. Frontal electrodes contributed most to this difference in the 4-6 Hz theta, 12-18 Hz beta and 30-45 Hz gamma bands. On an individual basis, the combination of six spectral power band parameters discr...

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“…Previous studies on patients with PD have reported an altered pattern of ERD/ ERS during voluntary movement, and suggested the involvement of the basal ganglia and dopaminergic activity in the generation of ERD/ERS. Patients with PD showed a smaller magnitude of beta ERD [18] , delayed alpha ERD and a smaller beta ERS that were partly restored by acute administration of levodopa [19] . Involvement of the basal ganglia and dopaminergic function are partly supported by recent studies that recorded local field potentials in the basal ganglia in patients with PD and showed that beta band oscillations in the basal ganglia are correlated with the cortical beta rhythm in both their temporal pattern and in their phase [24] : these local field potentials are critically dependent on the cerebral dopamine level [23,25] .…”

Section: Discussionmentioning

confidence: 93%

“…There is evidence supporting the assumption that ERD reflects activation of the cortices while ERS reflects inhibition or recovery of the activated areas [15,[20][21][22] , although their nature has not been fully elucidated. It has also been suggested, based on evidence related to Parkinson's disease (PD), that dopaminergic function of the basal ganglia is important in the generation of ERD and ERS [18,19] . Beta band oscillation in the basal ganglia has also been shown to correlate to some degree with cortical ERD and ERS [23][24][25] .…”

mentioning

confidence: 99%

Enhanced Reactivity and Delayed Recovery of Sensorimotor Cortex in the Novelty Seeking Personality

Shishida

Hashizume²,

Onoda³

et al. 2006

Neuropsychobiology

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Background: The novelty seeking (NS) personality trait is hypothesized to be associated with high cortical reactivity, poor inhibitory control and/or varied dopaminergic neurotransmission in the basal ganglia. After somatosensory stimulation, electrical oscillations in alpha and beta bands generated in the sensorimotor cortex show a short duration decrease (event-related desynchronization) and a subsequent increase (event-related synchronization) that is thought to reflect cortical activation and the inhibitory/recovery process, respectively. These oscillatory changes are also believed to be affected by the status of the basal ganglia and by dopaminergic functions. In the present study, we investigated the association between the NS personality trait and somatosensory oscillatory changes after median nerve stimulation assessed by magnetoencephalography. Methods: From 48 healthy subjects, we selected 14 high scorers and 14 age- and sex-matched low scorers on the NS dimension of the Temperament and Character Inventory. Magnetic fields were recorded while subjects received electrical stimulation of either the right or left median nerve with equal probability and with a randomized interstimulus interval. Frequency analysis was performed on the alpha and beta bands. Results: Compared with the low NS group, the high NS group showed larger magnitude of beta event-related desynchronization and larger latencies of the alpha and beta event-related synchronization. Conclusion: These results suggest that individuals with high degrees of the NS trait have greater reactivity and delayed recovery of the sensorimotor cortex in response to simple somatosensory stimulation. This may be significant for the understanding of their exploratory and impulsive behavior.

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Postmovement Beta Synchronization in Patients With Parkinson's Disease

Cited by 68 publications

References 32 publications

Post-Movement Beta Activity in Sensorimotor Cortex Indexes Confidence in the Estimations from Internal Models

Post-Movement Beta Activity in Sensorimotor Cortex Indexes Confidence in the Estimations from Internal Models

Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients

Enhanced Reactivity and Delayed Recovery of Sensorimotor Cortex in the Novelty Seeking Personality

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