Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia

Kelly, Matthew S.; Benjamin, Daniel K.; Puopolo, Karen M.; Laughon, Matthew M.; Clark, Reese H.; Mukhopadhyay, Sagori; Smith, P. Brian; Permar, Sallie R.

doi:10.1001/jamapediatrics.2015.3785

Cited by 79 publications

(100 citation statements)

References 38 publications

(46 reference statements)

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“…Compared to full-term infants they are at higher risk of serious postnatal complications and severe impairment [1][2][3]. In addition, the number of parents of VLBW infants is increasing and heterogeneous, as the causes of preterm birth are multifaceted and partly remain unexplained.…”

Section: Introductionmentioning

confidence: 99%

Communicating with parents in neonatal intensive care units: The impact on parental stress

Enke

Hausmann

Miedaner

et al. 2017

Patient Education and Counseling

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Section: Introductionmentioning

confidence: 99%

Communicating with parents in neonatal intensive care units: The impact on parental stress

Enke

Hausmann

Miedaner

et al. 2017

Patient Education and Counseling

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“…Postnatal CMV infection can be diagnosed by the detection of CMV using culture or PCR of blood, urine, cerebrospinal fluid, or respiratory secretions after 2 to 3 weeks of life 1,7,10) . Demon stration of CMV-specific IgM in cord blood or in the infant's blood within the first 2 to 3 weeks of life suggests congenital CMV infection 7,10) .…”

Section: Resultsmentioning

confidence: 99%

“…Demon stration of CMV-specific IgM in cord blood or in the infant's blood within the first 2 to 3 weeks of life suggests congenital CMV infection 7,10) .…”

Section: Resultsmentioning

confidence: 99%

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Breast Milk-Transmitted Cytomegalovirus Infection in Preterm Infants

Gang

Chang

2018

Neonatal Med

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Purpose: The purpose of this study is to describe the rate of cytomegalovirus (CMV) virolactia, and the prevalence of breast milk (BM)-transmitted postnatal CMV infection among premature infants after freeze-thawing (FT) and Holder pasteurization (HP) of breast milk. Methods: This is a single-center, retrospective study of 312 infants born at less than 32 weeks of gestation, or with a birth weight less than 1,500 g from January 2013 to June 2017. All infants were screened for CMV-specific immunoglobulin (Ig) G and IgM at birth. Initial CMV specific polymerase chain reaction (PCR) and CMV culture were performed on mothers' BM and babies' urine within the first 21 days of life. FT and HP of BM was used to prevent the transmission of CMV. For the surveillance of postnatal CMV infection, CMV culture and CMV specific PCR of urine from babies were repeated one to two months after the initial screening. Screening for viremia and viruria was performed if postnatal CMV infection was suspected. Results: Among 178 BM samples obtained from mothers of CMV-IgG-seropositive infants, 80 (44.9%) were CMV PCR positive. CMV deoxyribonucleic acid (DNA) was detected in five of the 22 BM samples (22.7%) obtained from the mothers of CMV-IgG seronegative infants. When CMV DNA load in BM was measured before and after HP, various results were shown. Sixty-three infants out of 232 (27.2%) were evaluated for postnatal CMV infection and four infants out of 63 (6.3%) were infected. Conclusion: Interventions to prevent BM-transmitted CMV infection can reduce the chance of postnatal CMV infection, but not completely eliminate it.

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“…However, the effects of asymptomatic CMV infection on BPD or neurodevelopment have been suggested, and further research remains necessary [25,26]. Nevertheless, so far, CMV transmission through colostrum appears to be infrequent [11].…”

Section: Discussionmentioning

confidence: 99%

Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study

et al. 2017

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Background: Despite the critical importance of breast milk for preterm and sick neonates, there is no consensus regarding the use of raw mother's own milk (MOM) in neonatal units. Objectives: This study aimed to describe the use of raw MOM in hospitalised neonates before day 7 (early use), and to investigate: (i) related factors, (ii) maternal satisfaction, and (iii) the association with breastfeeding continuation. Methods: This prospective cohort included 516 neonates intended to be breastfed in 2 French neonatal units. Neonates receiving raw MOM before day 7 were compared to those who did not. The association between early use of MOM and breastfeeding continuation at hospital discharge, and up to 6 months later, was measured by logistic regression. Results: More than one-third (36.2%) of breastfed neonates did not receive any MOM during their first week, mainly due to organisational constraints and staff reluctance. Maternal satisfaction related to early raw MOM use was high (96%), and was coupled with a more frequent maternal feeling of being supported in breastfeeding (p = 0.003). There was a significant association between early use of MOM and breastfeeding continuation at discharge (OR 2.92, 95% CI 1.94-4.40, p < 0.0001), which persisted 6 months later (OR 2.70, 95% CI 1.21-6.03, p = 0.023). This association appeared independent in multivariable analyses (at discharge: aOR 2.03, 95% CI 1.27-3.25, p = 0.003; 6 months later: aOR 2.46, 95% CI 1.02-5.92, p = 0.045). Conclusion: While the early use of raw MOM in hospitalised neonates can be limited by multiple factors, it appears supportive for mothers, and might represent a simple opportunity to improve breastfeeding in neonatal units.

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Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia

Cited by 79 publications

References 38 publications

Communicating with parents in neonatal intensive care units: The impact on parental stress

Communicating with parents in neonatal intensive care units: The impact on parental stress

Breast Milk-Transmitted Cytomegalovirus Infection in Preterm Infants

Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study

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