Postnatal decline of maternally acquired rubella antibodies

Cloonan, M. J.; Hawkes, R. A.; Stevens, L. H.

doi:10.1017/s0022172400042364

Cited by 18 publications

(15 citation statements)

References 19 publications

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“…We have previously reported a high degree of variability in the rate of decline of maternally acquired rubella antibody in the babies used in the present study (Cloonan et al 1970). For that antibody the range of half-lives was between 14 and 70 days, with the exception of three babies whose values were between 74 and 259 days.…”

Section: Discussionmentioning

confidence: 61%

“…The babies in this study and the collection of test sera have been described previously (Cloonan et al 1970). Although there were 120 babies in the original group, sufficient serum was left from only 102 babies for the influenza A2 tests and from only 70 babies for the parainfluenza type 3 tests.…”

Section: Methodsmentioning

confidence: 99%

“…After this, antibody declined in an exponential manner. These five babies were not members of the group of ten babies in which similar variations in rubella antibody titre occurred early in life (Cloonan, et al 1970). …”

Section: Serological Techniquesmentioning

confidence: 97%

“…In a previous study we have shown that the rate of postnatal decline (half-life) of maternally acquired rubella antibody in a large group of infants was highly variable, with half-lives in different children ranging between 14 and 70 days (Cloonan, Hawkes & Stevens, 1970). A significant relationship was found between the half-life and the rubella antibody titre at or near birth ('initial titre') which could be described by a rectangular hyperbola, such that babies having high titres at birth lost their antibody rapidly, whereas in those with low initial titres antibody declined at a slower rate.…”

Section: Introductionmentioning

confidence: 99%

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Postnatal decline of maternally acquired viral antibodies of different specificities

Cloonan

Hawkes

Stevens

1971

J. Hyg.

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SUMMARYThe rates of decline (half-lives) of maternally acquired antibodies of two different specificities in a group of infants were found to be highly variable, ranging from 18 to 192 days for parainfluenza type 3 antibody (54 infants) and from 15 to 251 days for influenza A2 antibody (nine infants). For antibodies of both specificities approximately 75 % of the half-lives were between 15 and 60 days. With parainfluenza type 3 antibody, and possibly with influenza A 2 antibody, the half-lives were inversely proportional to the initial antibody titre of the babies' sera. This relationship could be described by a rectangular hyperbola. Babies with high antibody titres at birth lost this antibody rapidly whereas in babies with low initial titres antibody declined over a longer period.The half-lives of parainfluenza type 3 antibody and influenza A 2 antibody were compared with that of rubella antibody in the same group of infants (previously published). Maternally acquired viral antibodies of different specificities did not necessarily decline at similar rates in any given child. In nine infants, maternally acquired antibodies of two different specificities (rubella and parainfluenza type 3) declined at significantly different rates in the same child. It is suggested that although the half-life of antibody of a given specificity is related to its concentration in the serum, it is independent of the level of serum antibodies of other specificities.

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Section: Discussionmentioning

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Section: Serological Techniquesmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Postnatal decline of maternally acquired viral antibodies of different specificities

Cloonan

Hawkes

Stevens

1971

J. Hyg.

Self Cite

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“…After the age of 1 year the ability to detect low titres of 1gM in a minority of patients is only of occasional value, since congenital infection can usually be inferred from the presence of HI antibody. But between 6 months and 1 year the presence of a low HI titre is difficult to interpret since some normal infants still have maternal antibody at the age of nine months (Cloonan, Hawkes & Stevens, 1970). In this age group RIA has a clear advantage as a method for detecting IgM since in our hands it was successful with 9 out of 17 sera (53 % whereas IF gave positive results with only 4 out of 16 (25 %) and one of these was probably non-specific.…”

Section: Discussionmentioning

confidence: 99%

Comparison of immunofluorescence and radioimmunoassay for detecting IgM antibody in infants with the congenital rubella syndrome

Cradock-Watson

Ridehalgh

Pattison

et al. 1979

J. Hyg.

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SUMMARYImmunofluorescence (IF) and radioimmunoassay (RIA) have been compared as methods for detecting IgM antibody in 124 infants with confirmed or suspected congenital rubella. IF was used to test sucrose density gradient fractions and RIA to test fractions and whole serum.When fractions were tested IF and RIA were equally specific and distinguished clearly between IgM and IgG, but RIA was the more sensitive method. The RIA titre in whole serum was always greater than in the peak IgM fraction and there was no evidence that testing the serum, rather than the fraction, could result in failure to detect IgM. With some sera RIA gave low titres which became negative after absorption with IgG-coated latex beads. The mechanism of this 'false positive' effect, which may have been due to IgM with anti-IgG activity, was not investigated, but if it can be removed by absorption it need not reduce the specificity of the test.During the first 6 months of life IgM antibody was detected by RIA in 30 out of 32 unfractionated sera and by IF in fractions from 28 of these. After the age of 6 months IgM was found progressively less frequently and the greater sensitivity of RIA became a more obvious advantage: 17 out of 60 specimens were positive by RIA and 11 of these were negative by IF.RIA testing of whole serum appears to be an economical, specific and sensitive method for detecting IgM antibody in congenital rubella, of particular value when the titre of antibody is low.

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A comparison of the evolution of transmitted IgG immunoglobulin and diphtheria antitoxin titers in the newborn

Cabau

Levy

Martins

1976

Med Microbiol Immunol

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The evolution of the titers of transmitted IgG and diphtheria antitoxin was studied in 20 neonates during the first 2 months of life (6 serum samples for each). A rapid fall of the passive IgG titer was observed during the first weeks: as a rule the higher the initial titer the greater the fall. After the 15th day the rate of decline slows down. The evolution of the titer of transmitted maternal diphtheria antitoxin depends also on the initial level, and if it is low it can remain more or less constant for a long time. The initial level of passive IgG does not influence the drop in diphtheria antitoxin titre and vice versa. Therefore, the evolution of total IgG and diphtheria antitoxin levels appear not to be interdependent.

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Postnatal decline of maternally acquired rubella antibodies

Cited by 18 publications

References 19 publications

Postnatal decline of maternally acquired viral antibodies of different specificities

Postnatal decline of maternally acquired viral antibodies of different specificities

Comparison of immunofluorescence and radioimmunoassay for detecting IgM antibody in infants with the congenital rubella syndrome

A comparison of the evolution of transmitted IgG immunoglobulin and diphtheria antitoxin titers in the newborn

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