Postnatal development and functional histology of the sebaceous glands in the rat

Parnell, Jerome P.

doi:10.1002/aja.1000850104

Cited by 33 publications

(3 citation statements)

References 13 publications

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“…In contrast, in mice and rats the sebaceous glands function in cycles. In these animals, during the resting phase, the glands regress to become smaller, but they do not involute to acquire again an undifferentiated character [40,41 ]. This observation does not corroborate the hypothesis that in man mantles represent a stage in a sebaceous cycle.…”

Section: The Function Of Mantles Remains Enigmaticcontrasting

confidence: 40%

The ‘Mantle Hair of Pinkus’

Viragh¹

1995

Dermatology

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The ‘mantle hair’ is a hair follicle which is characterized by a circumferential proliferation of basaloid epithelial cells emanating from the base of its infundibulum. These cells show varying sebaceous differentiation. The mantle hair was first described 100 years ago. Since then, this type of hair follicle with its particular sebaceous gland has been forgotten repeatedly, to be rediscovered anew. Thus, a confusing terminology has evolved, and concepts of its nature are controversial. In this article we present a review of the 100-year history of the mantle hair.

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Section: The Function Of Mantles Remains Enigmaticcontrasting

confidence: 40%

The ‘Mantle Hair of Pinkus’

Viragh¹

1995

Dermatology

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“…The concept of a cyclic CDA activation fits well with the observation of a stochastic expulsion of sebum and the squamous cell layer formation in the skin. A cyclic regulation of sebum production has been previously suggested to occur in other rodents as well [44].…”

Section: Discussionmentioning

confidence: 84%

Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages

et al. 2019

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In the adult mammalian skin, cells are constantly renewing, differentiating and moving upward, to finally die in a yet not fully understood manner. Here, we provide evidence that macroautophagy/autophagy has a dual role in the skin. In addition to its known catabolic protective role as an evolutionary conserved upstream regulator of lysosomal degradation, we show that autophagy induced cell death (CDA) occurs in epithelial lineage-derived organs, such as the inter-follicular epidermis, the sebaceous-and the Harderian gland. By utilizing GFP-LC3 transgenic and ATG7-deficient mice, we show that CDA is initiated during terminal differentiation at a stage when the cells have become highly resistant to apoptosis. In these transitional cells, the Golgi compartment expands, which accounts for the formation of primary lysosomes, and the nucleus starts to condense. During CDA a burst of autophagosome formation is observed, first the endoplasmic reticulum (ER) is phagocytosed followed by autophagy of the nucleus. By this selective form of cell death, most of the cytoplasmic organelles are degraded, but structural proteins remain intact. In the absence of autophagy, consequently, parts of the ER, ribosomes, and chromatin remain. A burst of autophagy was stochastically observed in single cells of the epidermis and collectively in larger areas of ductal cells, arguing for a coordinated induction. We conclude that autophagy is an integral part of cell death in keratinocyte lineage cells and participates in their terminal cell fate.

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“…The concept that esterases play a role in detoxification, and also in lipid-ester metabolism in general [5,6,7,19], is in keeping with the present observations of the localization of sebaceous ester ases. As a result of the mitotic activity [25,35] and lipid metabolism [25,33,34] in sebaceous glands there is likely to be a considerable ester turnover, many of the esters being potentially toxic if they were to enter the general circulation. An idea of the total possible turnover is given by the distribution density of sebaceous glands, and also by sebum levels.…”

Section: Discussionmentioning

confidence: 99%