Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy

Burt, Dorothy K.; Hungerford, Suzanne M.; Crowner, Martha; Baez, Luis A.

doi:10.1016/0091-3057(82)90410-5

Cited by 24 publications

(8 citation statements)

References 48 publications

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“…For example , anticholinergic drugs antagonize haloperidol-induced catalepsy beginning at 15 days of age (Burt , Hungerford, Crowner, and Baez, 1982).…”

Section: Discussionmentioning

confidence: 99%

Haloperidol differentially potentiates tonic immobility, the dorsal immobility response, and catalepsy in the developing rat

Meyer

Smith

Hartesveldt

1984

Developmental Psychobiology

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The effects of a single subcutaneous injection of haloperidol (1 or 10 mg/kg) or the vehicle solution on three kinds of behavioral inhibition were investigated in rats of 10, 15, and 20 days of age. The behaviors measured were tonic immobility, a response induced by placing an animal on its back supported by a V-shaped trough; the dorsal immobility response, which can be elicited in young rodents by grasping the skin of the dorsal surface of the neck and lifting the animal into the air; and catalepsy, a form of immobility in which animals remain in unusual postures but are capable of righting themselves, and which can be elicited by drugs which block dopamine receptors. Haloperidol (10 mg/kg) significantly potentiated the duration of tonic immobility only at 10 days of age; potentiated catalepsy at all age levels, but significantly less in the 15-day-old rats than in the 10- or 20-day-old rats; and potentiated the duration of the dorsal immobility response in the 10- and 20-day-old animals but not in the 15-day-olds. These results are discussed with respect to the development of neurotransmitter systems in the brain.

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“…For example , anticholinergic drugs antagonize haloperidol-induced catalepsy beginning at 15 days of age (Burt , Hungerford, Crowner, and Baez, 1982).…”

Section: Discussionmentioning

confidence: 99%

Haloperidol differentially potentiates tonic immobility, the dorsal immobility response, and catalepsy in the developing rat

Meyer

Smith

Hartesveldt

1984

Developmental Psychobiology

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“…Striatal ACh levels follow a similar developmental trajectory (Coyle and Campochiaro, 1976;Coyle and Yamamura, 1976;Phelps et al, 1989). The protracted postnatal maturation of ACh neurochemistry has been suggested to underlie a delayed interaction between cholinergic and dopaminergic pharmacology in the developing rodent, which reaches functional maturity around P20 (Burt et al, 1982;Fitzgerald and Hannigan, 1989). In addition, although striatal ChIs appear in tandem with basal forebrain cholinergic neurons, their functional development lags behind the basal forebrain system (Phelps et al, 1989), suggesting that cues specific to the striatum may contribute to ChI maturation.…”

Section: The Maturation Of the Striatal Cholinergic Systemmentioning

confidence: 95%

Coordinated Postnatal Maturation of Striatal Cholinergic Interneurons and Dopamine Release Dynamics in Mice

et al. 2021

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Dynamic changes in motor abilities and motivated behaviors occur during the juvenile and adolescent periods. The striatum is a subcortical nucleus critical to action selection, motor learning, and reward processing. Its tonically active cholinergic interneuron (ChI) is an integral regulator of the synaptic activity of other striatal neurons, as well as afferent axonal projections of midbrain dopamine (DA) neurons; however, little is known about its development. Here, we report that ChI spontaneous activity increases during postnatal development of male and female mice, concomitant with a decreased afterhyperpolarization (AHP). We characterized the postnatal development of four currents that contribute to the spontaneous firing rate of ChIs, including I SK , I A , I h , and I NaP . We demonstrated that the developmental increase in I NaP drives increased ChI firing rates during the postnatal period and can be reversed by the I NaP inhibitor, ranolazine. We next addressed whether immature cholinergic signaling may lead to functional differences in DA release during the juvenile period. In the adult striatum, nicotinic acetylcholine receptors (nAChRs) prevent linear summation of DA release in response to trains of high-frequency stimuli. We show that, in contrast, during the second postnatal week, DA release linearly sums with trains of high-frequency stimuli. Consistently, nAChR antagonists exert little effect on dopamine release at postnatal day (P)10, but enhance the summation of evoked DA release in mice older than postnatal day P28. Together, these results reveal that postnatal maturation of ChI activity is due primarily to enhanced I NaP and identify an interaction between developing cholinergic signaling and DA neurotransmission in the juvenile striatum.

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“…1990), brainstem choline acetyltransferase activity (Ninomiya et al . 2001) and acetylcholine‐mediated behaviors (Burt et al . 1982; Fibiger et al .…”

Section: Acetylcholine and Basmentioning

confidence: 99%

The ontogeny of mammalian sleep: a reappraisal of alternative hypotheses

Frank

Heller

2003

Journal of Sleep Research

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SUMMAR Y Newborn mammals spend as much as 90% or more of their time in a sleep state characterized by frequent twitches, rapid eye movements (REMs), and irregular respiratory cycles. These motor and respiratory patterns resemble the phasic motor ⁄ respiratory components of adult REM sleep, and as a consequence, this sleep state is traditionally viewed as an immature form of REM sleep. An alternative view is that a significant portion of what has been called REM sleep in these species is a form of spontaneous activity typical of the immature nervous system. In this review, we compare and contrast these two opposing views about the ontogenetic origins of REM sleep, and review the evidence most often cited to support the idea that REM sleep is present in newborn altricial mammals. Critical review of this evidence indicates that REM sleep may not be present at birth in these species; rather, it appears that all mammals early in development exhibit spontaneous, dissociated activity that progressively becomes organized into the distinct states of REM and non-rapid eye movement sleep.k e y w o r d s active sleep, neonatal sleep, ontogeny, postnatal

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Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy

Cited by 24 publications

References 48 publications

Haloperidol differentially potentiates tonic immobility, the dorsal immobility response, and catalepsy in the developing rat

Haloperidol differentially potentiates tonic immobility, the dorsal immobility response, and catalepsy in the developing rat

Coordinated Postnatal Maturation of Striatal Cholinergic Interneurons and Dopamine Release Dynamics in Mice

The ontogeny of mammalian sleep: a reappraisal of alternative hypotheses

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