Postnatal development of calretinin- and parvalbumin-positive interneurons in the rat neostriatum: An immunohistochemical study

Schlösser, B.; Klausa, G; G, Prime; G, Ten Bruggencate

doi:10.1002/(sici)1096-9861(19990308)405:2<185::aid-cne4>3.0.co;2-b

Cited by 46 publications

(43 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This DMS to DLS response difference may be explained by the higher expression of FSIs in the DLS (Schlösser et al, 1999;Luk and Sadikot, 2001), as the majority of mIPSCs onto MSNs arise from FSIs (Koos et al, 2004). Taking the DOR-mediated depression of FSI-MSN synapses in the DLS following acute EtOH exposure together with the reported increase in GABA transmission onto DMS MSNs, EtOH appears to shape the global output of the striatum by modulating GABA synapses.…”

Section: Discussioncontrasting

confidence: 70%

“…MSNs synapse upon the distal dendrites of other MSNs while FSIs form multiple synapses upon MSNs perisomatically to powerfully regulate MSN output (Koos et al, 2004). The FSI population increases in density laterally through the dorsal striatum (Schlösser et al, 1999;Luk and Sadikot, 2001), positioning these cells to influence DLS output to a greater extent than DMS output. FSIs and other striatal cell types, like MSNs, express a host of presynaptically localized G i/o -coupled receptors such as the cannabinoid type 1 receptor (CB1) and 5-HT1b, among others (Mathur et al, 2011(Mathur et al, , 2013Atwood et al, 2014a, b).…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Ethanol Disinhibits Dorsolateral Striatal Medium Spiny Neurons Through Activation of A Presynaptic Delta Opioid Receptor

Patton

Roberts

Lovinger

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

The dorsolateral striatum mediates habit formation, which is expedited by exposure to alcohol. Across species, alcohol exposure disinhibits the DLS by dampening GABAergic transmission onto this structure's principal medium spiny projection neurons (MSNs), providing a potential mechanistic basis for habitual alcohol drinking. However, the molecular and circuit components underlying this disinhibition remain unknown. To examine this, we used a combination of whole-cell patch-clamp recordings and optogenetics to demonstrate that ethanol potently depresses both MSN-and fast-spiking interneuron (FSI)-MSN GABAergic synaptic transmission in the DLS. Concentrating on the powerfully inhibitory FSI-MSN synapse, we further show that acute exposure of ethanol (50 mM) to striatal slices activates delta opioid receptors that reside on FSI axon terminals and negatively couple to adenylyl cyclase to induce a long-term depression of GABA release onto both direct and indirect pathway MSNs. These findings elucidate a mechanism through which ethanol may globally disinhibit the DLS.

show abstract

Section: Discussioncontrasting

confidence: 70%

Section: Introductionmentioning

confidence: 97%

Ethanol Disinhibits Dorsolateral Striatal Medium Spiny Neurons Through Activation of A Presynaptic Delta Opioid Receptor

Patton

Roberts

Lovinger

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Shh binds to Patched homolog 1 or 2, which in turn relieves the repression of the serpentine transmembrane protein Smo, the obligatory Shh transducer (Ingham & McMahon, 2001). Striatal ACh and FS acquire their phenotype during the first 2–3 postnatal weeks in rodents along with the expression of specific markers such as choline acetyltransferase (ChAT, Ach; Phelps, Brady, & Vaughn, 1989) and parvalbumin (PV, FS; Schlösser, Klausa, Prime, & Bruggencate, 1999). To conditionally delete Smo in ACh or FS, we selected the ChAT‐Cre (Rossi et al, 2011) and PV‐Cre (Hippenmeyer et al, 2005) lines (Figure 2a,e).…”

Section: Resultsmentioning

confidence: 99%

Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits

Sanchez-Garcia

Nieto-González

García-Junco-Clemente

et al. 2018

Aging Cell

View full text Add to dashboard Cite

The striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently affected in several neurological diseases. The glial cell line‐derived neurotrophic factor (GDNF), synthesized by striatal interneurons, and Sonic hedgehog (Shh), produced by the dopaminergic neurons of the substantia nigra (DA SNpc), are both involved in the nigrostriatal maintenance but the reciprocal neurotrophic relationships among these neurons are only partially understood. To define the postnatal neurotrophic connections among fast‐spiking GABAergic interneurons (FS), cholinergic interneurons (ACh), and DA SNpc, we used a genetically induced mouse model of postnatal DA SNpc neurodegeneration and separately eliminated Smoothened (Smo), the obligatory transducer of Shh signaling, in striatal interneurons. We show that FS postnatal survival relies on DA SNpc and is independent of Shh signaling. On the contrary, Shh signaling but not dopaminergic striatal innervation is required to maintain ACh in the postnatal striatum. ACh are required for DA SNpc survival in a GDNF‐independent manner. These data demonstrate the existence of three parallel but interdependent neurotrophic relationships between SN and striatal interneurons, partially defined by Shh and GDNF. The definition of these new neurotrophic interactions opens the search for new molecules involved in the striatal modulatory circuit maintenance with potential therapeutic value.

show abstract

“…Later during development, at midgestation, CalR + cells almost entirely overlap with immunoreactivity to GABA (Rakic and Zecevic, 2003; Zecevic et al, 2005). During development however, the number of CalR + cells decreases while at the same time levels of other calcium binding proteins expressed in GABAergic neurons, such as calbindin or parvalbumin, increase (Yan et al, 1995, 1996; Schlösser et al, 1999; Brandt et al, 2003). In addition, the percentage of CalR + /GABA + cells is reduced from 96% at midgestation to 37% in adulthood in primates (Del Río and DeFelipe, 1994; Yan et al, 1995), suggesting that CalR could have an important role in other cortical cell types during development.…”

Section: Discussionmentioning

confidence: 99%

“…By their electrophysiological output, they belong to accommodating or irregular-spiking interneurons (Porter et al, 1998) that target not only the distal dendrites of pyramidal cells, but importantly also other GABAergic interneurons. Their function in the primate cortex is complex, since they can disinhibit pyramidal cells by making synapses on each other (DeFelipe et al, 1999; Schlösser et al, 1999; Lewis et al, 2005; Zaitsev et al, 2005). The specific distribution of CalR + cells in human upper cortical layers (II/III) suggests a role in cortical circuit formation necessary for higher brain functions specific to humans, such as abstract thinking and language (Hill and Walsh, 2005; Jones, 2009; Rakic, 2009).…”

Section: Introductionmentioning

confidence: 99%

The complexity of the calretinin-expressing progenitors in the human cerebral cortex

et al. 2014

View full text Add to dashboard Cite

The complex structure and function of the cerebral cortex critically depend on the balance of excitation and inhibition provided by the pyramidal projection neurons and GABAergic interneurons, respectively. The calretinin-expressing (CalR+) cell is a subtype of GABAergic cortical interneurons that is more prevalent in humans than in rodents. In rodents, CalR+ interneurons originate in the caudal ganglionic eminence (CGE) from Gsx2+ progenitors, but in humans it has been suggested that a subpopulation of CalR+ cells can also be generated in the cortical ventricular/subventricular zone (VZ/SVZ). The progenitors for cortically generated CalR+ subpopulation in primates are not yet characterized. Hence, the aim of this study was to identify patterns of expression of the transcription factors (TFs) that commit cortical stem cells to the CalR fate, with a focus on Gsx2. First, we studied the expression of Gsx2 and its downstream effectors, Ascl1 and Sp8 in the cortical regions of the fetal human forebrain at midgestation. Next, we established that a subpopulation of cells expressing these TFs are proliferating in the cortical SVZ, and can be co-labeled with CalR. The presence and proliferation of Gsx2+ cells, not only in the ventral telencephalon (GE) as previously reported, but also in the cerebral cortex suggests cortical origin of a subpopulation of CalR+ neurons in humans. In vitro treatment of human cortical progenitors with Sonic hedgehog (Shh), an important morphogen in the specification of interneurons, decreased levels of Ascl1 and Sp8 proteins, but did not affect Gsx2 levels. Taken together, our ex-vivo and in vitro results on human fetal brain suggest complex endogenous and exogenous regulation of TFs implied in the specification of different subtypes of CalR+ cortical interneurons.

show abstract

Postnatal development of calretinin- and parvalbumin-positive interneurons in the rat neostriatum: An immunohistochemical study

Cited by 46 publications

References 77 publications

Ethanol Disinhibits Dorsolateral Striatal Medium Spiny Neurons Through Activation of A Presynaptic Delta Opioid Receptor

Ethanol Disinhibits Dorsolateral Striatal Medium Spiny Neurons Through Activation of A Presynaptic Delta Opioid Receptor

Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits

The complexity of the calretinin-expressing progenitors in the human cerebral cortex

Contact Info

Product

Resources

About