Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus

Venkataraman, Yamini; Bartlett, Edward E.

doi:10.1152/jn.00021.2013

Cited by 26 publications

(36 citation statements)

References 99 publications

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“…A recent study (Venkataraman and Bartlett, 2013) showed that electrical stimulation of the brachium of the IC elicited purely inhibitory response in 41% of medial geniculate neurons at postnatal day 27. It is possible that such neurons are driven exclusively by excitatory inputs from the cerebral cortex, and the ascending sensory information from the LG neurons modulates the corticothalamic input.…”

Section: Discussionmentioning

confidence: 99%

Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons

Ito

Oliver

2014

J of Comparative Neurology

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Large GABAergic (LG) neurons are a distinct type of neuron in the inferior colliculus (IC) identified by their dense VGLUT2-containing axosomatic synaptic terminals. Yet, the sources of these terminals are unknown. Since IC glutamatergic neurons express VGLUT2, and IC neurons are known to have local collaterals, we tested the hypothesis that these excitatory, glutamatergic axosomatic inputs on LG neurons come from local axonal collaterals and commissural IC neurons. We injected a recombinant viral tracer into the IC which enabled Golgi-like GFP labeling in both dendrites and axons. In all cases, we found terminals positive for both GFP and VGLUT2 (GFP+/VGLUT2+) that made axosomatic contacts on LG neurons. One to six axosomatic contacts were made on a single LG cell body by a single axonal branch. The GFP-labeled neurons giving rise to the VGLUT2+ terminals on LG neurons were close by. The density of GFP+/VGLUT2+ terminals on the LG neurons was related to the number of nearby GFP-labeled cells. On the contralateral side, a smaller number of LG neurons received axosomatic contacts from GFP+/VGLUT2+ terminals. In cases with a single GFP-labeled glutamatergic neuron, the labeled axonal plexus was flat, oriented in parallel to the fibrodendritic laminae, and contacted 9–30 LG cell bodies within the plexus. Our data demonstrated that within the IC microcircuitry, there is a convergence of inputs from local IC excitatory neurons on LG cell bodies. This suggests that LG neurons are heavily influenced by the activity of the nearby laminar glutamatergic neurons in the IC.

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Section: Discussionmentioning

confidence: 99%

Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons

Ito

Oliver

2014

J of Comparative Neurology

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“…Offset neurons are found in the IC and other auditory nuclei and depend on a balance of excitatory and inhibitory neurotransmission (Kasai et al, 2012). In developing rats, agerelated changes occur in the properties of IC inhibition and in GABAergic projections to the medial geniculate body (MGB) of the thalamus (Venkataraman and Bartlett, 2013b). The time course of these changes is similar to that of the development of temporal coding, as assessed by evoked potentials, in developing young rats (Venkataraman and Bartlett, 2013a).…”

Section: B Temporal Codingmentioning

confidence: 99%

“…This increase in myelination likely results in reductions in neural conduction time as measured by inter-wave peak latencies in the auditory brainstem response (ABR) (Salamy, 1984;Gorga et al, 1989;Moore et al, 1996;Hurley et al, 2005). Reductions in neural conduction time may also be attributed to changes in synaptic function-animal models have demonstrated rapid developmental changes in brainstem and midbrain synaptic function in infancy (Sanes, 1993;Venkataraman and Bartlett, 2013b). Developmental changes in phase locking properties of neurons may affect encoding of the frequency components of the acoustic signal.…”

Section: Introductionmentioning

confidence: 99%

Development of subcortical speech representation in human infants

Anderson

Parbery‐Clark

White-Schwoch

et al. 2015

The Journal of the Acoustical Society of America

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Previous studies have evaluated representation of the fundamental frequency (F 0 ) in the frequency following response (FFR) of infants, but the development of other aspects of the FFR, such as timing and harmonics, has not yet been examined. Here, FFRs were recorded to a speech syllable in 28 infants, ages three to ten months. The F 0 amplitude of the response was variable among individuals but was strongly represented in some infants as young as three months of age. The harmonics, however, showed a systematic increase in amplitude with age. In the time domain, onset, offset, and inter-peak latencies decreased with age. These results are consistent with neurophysiological studies indicating that (1) phase locking to lower frequency sounds emerges earlier in life than phase locking to higher frequency sounds and (2) myelination continues to increase in the first year of life. Early representation of low frequencies may reflect greater exposure to low frequency stimulation in utero. The improvement in temporal precision likely parallels an increase in the efficiency of neural transmission accompanied by exposure to speech during the first year of life.

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“…The earlier development of low-frequency phase locking has also been demonstrated in midbrain structures (Pierson & Snyder-Keller, 1994;Romand & Ehret, 1990). Changes in synaptic transmission and increases in myelination may account for improved temporal precision with development (Brenowitz & Trussell, 2001;Sanes, 1993;Venkataraman & Bartlett, 2013).…”

mentioning

confidence: 89%

“…The group differences during the transition region may be associated with the development of synaptic efficiency during infancy. Venkataraman and Bartlett (2013) investigated GABAergic connections from the inferior colliculus to the thalamus in rat brain slices from three age groups (prehearing, immediate posthearing, and juvenile) and found that GABA inhibitory postsynaptic potentials Figure 5. Left panels: Average phase locking from individual responses to the /ga/ temporal fine structure (TFS) is represented in the timefrequency domain, with darker red colors indicating higher phase-locking frequency (PLF).…”

Section: Phase Lockingmentioning

confidence: 99%

Development of Phase Locking and Frequency Representation in the Infant Frequency-Following Response

Dyke

Lieberman

Presacco

et al. 2017

J Speech Lang Hear Res

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Purpose: This study investigates the development of phase locking and frequency representation in infants using the frequency-following response to consonant-vowel syllables. Method: The frequency-following response was recorded in 56 infants and 15 young adults to 2 speech syllables (/ba/ and /ga/), which were presented in randomized order to the right ear. Signal-to-noise ratio and F sp analyses were used to verify that individual responses were present above the noise floor. Thirty-six and 39 infants met these criteria for the /ba/ or /ga/ syllables, respectively, and 31 infants met the criteria for both syllables. Data were analyzed to obtain measures of phase-locking strength and spectral magnitudes.Results: Phase-locking strength to the fine structure in the consonant-vowel transition was higher in young adults than in infants, but phase locking was equivalent at the fundamental frequency between infants and adults. However, frequency representation of the fundamental frequency was higher in older infants than in either the younger infants or adults. Conclusion: Although spectral amplitudes changed during the first year of life, no changes were found with respect to phase locking to the stimulus envelope. These findings demonstrate the feasibility of obtaining these measures of phase locking and fundamental pitch strength in infants as young as 2 months of age.

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Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus

Abstract: Venkataraman Y, Bartlett EL. Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus.

Cited by 26 publications

References 99 publications

Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons

Local and commissural IC neurons make axosomatic inputs on large GABAergic tectothalamic neurons

Development of subcortical speech representation in human infants

Development of Phase Locking and Frequency Representation in the Infant Frequency-Following Response

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