Postnatal development of the dopamine transporter: a quantitative autoradiographic study

Cl, Coulter; Hk, Happe; Lc, Murrin

doi:10.1016/0165-3806(96)00004-1

Cited by 92 publications

(62 citation statements)

References 30 publications

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“…These results are in general agreement with previous studies suggesting that the functional efficacy of the DAT and D 2 receptor in regulating DA release decreases as the firing frequency increases (Chergui et al, 1994;Benoit-Marand et al, 2001). Although evidence has shown that DAT density is lower in NAc shell than in the dorsal striatum (Coulter et al, 1996), our results demonstrate that inhibition of DATs elicited meaningful changes in evoked DA concentration in both regions.…”

Section: Tonic and Phasic Dopamine Transmission In The Striatumsupporting

confidence: 82%

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

et al. 2009

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Dopamine (DA) release varies within subregions and local environments of the striatum, suggesting that controls intrinsic and extrinsic to the DA fibers and terminals regulate release. While applying fast-scan cyclic voltammetry and using tonic and phasic stimulus trains, we investigated the regulation of DA release in the dorsolateral to ventral striatum. The ratio of phasic-to-tonic-evoked DA signals varied with the average ongoing firing frequency, and the ratio was generally higher in the nucleus accumbens (NAc) compared with the dorsolateral striatum. At the normal average firing frequency, burst stimulation produces a larger increase in the DA response in the NAc than the dorsolateral striatum. This finding was comparable whether the DA measurements were made using in vitro brain slices or were recorded in vivo from freely moving rodents. Blockade of the dopamine transporters and dopamine D 2 receptors particularly enhanced the tonic DA signals. Conversely, blockade of nicotinic acetylcholine receptors (nAChRs) containing the ␤ 2 subunit (␤ 2 *) predominantly suppressed tonic DA signals. The suppression of tonic DA release increased the contrast between phasic and tonic DA signals, and that made the frequencydependent DA dynamics between the dorsolateral striatum and NAc more similar. The results indicate that intrinsic differences in the DA fibers that innervate specific regions of the striatum combine with (at least) DA transporters, DA receptors, and nAChRs to regulate the frequency dependence of DA release. A combination of mechanisms provides specific local control of DA release that underlies pathway-specific information associated with motor and reward-related functions. Dopamine (DA) neurons operate in distinct tonic and phasic timescales to differentiate behaviorally relevant information (Schultz, 2007). DA neurons discharge tonically at low frequencies that consist of individual action potentials without bursts . Periodically, DA neurons fire in phasic bursts of near 20 Hz and greater (Hyland et al., 2002;Robinson et al., 2004). Evidence indicates that phasic or burst firing induces greater extracellular DA release compared with tonic, single-spike firing activity (Gonon, 1988;Grace, 1991;Floresco et al., 2003). Those tonic and phasic signals arise from midbrain DA neurons of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) that innervate the whole dorsal to ventral extent of the striatum. Although the DA neurons that project to the prefrontal cortex may have higher discharge rates (Chiodo et al., 1984;Lammel et al., 2008), many midbrain DA neurons often exhibit similar overall firing properties (Schultz, 1986;Clark and Chiodo, 1988;Gariano et al., 1989;Robinson et al., 2004). Reward-related sensory input, however, such as that initiated by an addictive drug, enhances DA release to varying degrees depending on the dopaminergic pathway and target region (Pontieri et al., 1996;Nisell et al., 1997;Shi et al., 2000;Di Chiara et al., 2004;Janhunen and Ahtee, 2007). Th...

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Section: Tonic and Phasic Dopamine Transmission In The Striatumsupporting

confidence: 82%

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

et al. 2009

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“…Since the D2 autoreceptors, as well as D3 receptors, have a higher affinity for DA than the postsynaptic D2 receptors, this will likely lead to more D2-like rCBV responses compared to the higher amounts of DA efflux seen in adults [Chen et al, 2005]. There could also be some effect of incomplete development of the DAT at P22 [Coulter et al, 1996;Galineau et al, 2004].…”

Section: Discussionmentioning

confidence: 96%

“…We compared the DA efflux with data from prior autoradiographic analysis of the maturation of DAT binding [Coulter et al, 1996;Galineau et al, 2004] ( fig. 5 b).…”

Section: Rcbv Response To Da Ligandsmentioning

confidence: 99%

Pharmacologic Neuroimaging of the Ontogeny of Dopamine Receptor Function

Chen

Choi

et al. 2010

Dev Neurosci

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Characterization of the ontogeny of the cerebral dopaminergic system is crucial for gaining a greater understanding of normal brain development and its alterations in response to drugs of abuse or conditions such as attention-deficit hyperactivity disorder. Pharmacological MRI (phMRI) was used to determine the response to dopamine transporter (DAT) blockers cocaine and methylphenidate (MPH), the dopamine releaser D-amphetamine (AMPH), the selective D1 agonist dihydrexidine, and the D2/D3 agonist quinpirole in young (<30 days old) and adult (>60 days old) rats. In adult rats, cocaine (0.5 mg/kg i.v.) or MPH (2 mg/kg) induced primarily positive cerebral blood volume (rCBV) changes in the dopaminergic circuitry, but negative rCBV changes in the young animals. Microdialysis measurements in the striatum showed that young rats have a smaller increase in extracellular dopamine in response to cocaine than adults. The young rats showed little rCBV response to the selective D1 agonist dihydrexidine in contrast to robust rCBV increases observed in the adults, whereas there was a similar negative rCBV response in the young and adult rats to the D2 agonist quinpirole. We also performed a meta-analysis of literature data on the development of D1 and D2 receptors and the DAT. These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age.

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“…[7]) likewise appears to increase into adolescence. Weanling rats exhibit only about 70% of adult levels of the DA transporter in PFC, ACC, and olfactory tubercles [102], while binding to the DA and 5HT transporters reach levels not significantly different from adults by early-mid adolescence (P28-35) [545]. Cholinergic innervation of PFC also increases to reach mature levels in adolescence in rats [208] and humans [298].…”

Section: Alterations In Prefrontal Cortex and Limbic Brain Regionsmentioning

confidence: 99%

The adolescent brain and age-related behavioral manifestations

Spear

2000

Neuroscience & Biobehavioral Reviews

4,742

110

4,301

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To successfully negotiate the developmental transition between youth and adulthood, adolescents must maneuver this often stressful period while acquiring skills necessary for independence. Certain behavioral features, including age-related increases in social behavior and risk-taking/novelty-seeking, are common among adolescents of diverse mammalian species and may aid in this process. Reduced positive incentive values from stimuli may lead adolescents to pursue new appetitive reinforcers through drug use and other risk-taking behaviors, with their relative insensitivity to drugs supporting comparatively greater per occasion use. Pubertal increases in gonadal hormones are a hallmark of adolescence, although there is little evidence for a simple association of these hormones with behavioral change during adolescence. Prominent developmental transformations are seen in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems. Developmental changes in these stressor-sensitive regions, which are critical for attributing incentive salience to drugs and other stimuli, likely contribute to the unique characteristics of adolescence. ᭧

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Postnatal development of the dopamine transporter: a quantitative autoradiographic study

Cited by 92 publications

References 30 publications

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum

Pharmacologic Neuroimaging of the Ontogeny of Dopamine Receptor Function

The adolescent brain and age-related behavioral manifestations

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