Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants

Nagayama, Junya; Okamura, Ken; Iida, Takao; Hirakawa, Hironori; Matsueda, Takahiko; Tsuji, Hiroshi; Hasegawa, Mayumi; Sato, Kasumi; Ma, Using-Yi; Yanagawa, Takashi; Igarashi, Hisaji; Fukushige, Junichiro; Watanabe, Tadayoshi

doi:10.1016/s0045-6535(98)00244-6

Cited by 85 publications

(47 citation statements)

References 8 publications

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“…Yet, children whose mothers are at the "high end" of the background population, in terms of TEQ and total PCBs, appear to function less well than children whose mothers are at the "low end" of the population. These results, which are in general agreement with those involving other populations in the United States and Japan (15)(16)(17)(18)(19)(20) …”

Section: (See Patandin Et Al P 45)supporting

confidence: 89%

Dietary Exposure to PCBs and Dioxins in Children

Birnbaum¹,

Slezak²

1999

Environmental Health Perspectives

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Section: (See Patandin Et Al P 45)supporting

confidence: 89%

Dietary Exposure to PCBs and Dioxins in Children

Birnbaum¹,

Slezak²

1999

Environmental Health Perspectives

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“…In Japan, the relationship between the concentration of dioxins (PCDD/PCDF) and co-planar PCB in breast milk, subpopulations of lymphocytes and the thyroid function in 101 mother-child pairs were investigated 62) . Breast milk samples were taken 2 to 4 months after delivery and blood samples one year after birth.…”

Section: Effects On Humansmentioning

confidence: 99%

The Effects of Dioxin on Reproduction and Development.

Yonemoto

2000

INDUSTRIAL HEALTH

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The developmental effects of dioxin are important because of the high sensitivity of mammals as well as the irreversibility and longevity of the effects. In animal experiments, exposure to dioxin during pregnancy and lactation induce various functional effects on offspring at very low doses. In humans, even if there is no exposure to dioxin after birth, there might be effects on thyroid function in infants exposed to dioxin from breast milk. In this report, low-dose developmental effects of dioxins on offspring in animal experiments and human studies were reviewed. In terms of risk assessment, methods to describe dosimetry, models to describe dose-response and approaches to express health risk are discussed.

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“…Continuous exposure of lactating mothers to polychlorinated biphenyls results in significant effects on Leydig cells structure and function in the adult offspring males: Leydig cells hypotrophy and reduced capacity to produce testosterone in vitro in response to luteinizing hormone stimulation (Kim et al, 2000). It is reported that polychlorinated biphenyls disrupt the thyroid gland function in humans (Langer et al, 1998;Cheek et al, 1999;Nagayama et al, 1998) and in many other mammalian species, e.g. the rat (Collins, 1980;Saeed and Hansen 1985;Fig.…”

Section: Leydig Cellsmentioning

confidence: 99%