Postnatal Fluoxetine Treatment Alters Perineuronal Net Formation and Maintenance in the Hippocampus

Mukhopadhyay, Sourish; Chatterjee, Ashmita; Tiwari, Praachi; Ghai, Utkarsha; Vaidya, Vidita A.

doi:10.1523/eneuro.0424-20.2021

Cited by 17 publications

(21 citation statements)

References 96 publications

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“… Species Age during manipulation Age at measurement Sex Experimental paradigm Brain region Method Measure Outcome Reference Rat (Sprague-Dawley) Early postnatal; adolescent Adolescent ♂ MS 4h/day; 500uM TAT2A microinjection into PFC every other day from P31–P39 Prelimbic cortex IHC PV cell density rescued MS-induced decrease [49] Ganguly et al. (2015) Rat (Sprague-Dawley) Early postnatal Juvenile; adult ♂ Oral FLX 10 mg/kg/d from P2–P21 Prelimbic cortex IHC; WFA stain PV cell density no change [113] Mukhopadhyay et al. (2021) Rat (Wistar) Adult Adult ♂ EE 2 months Prelimbic cortex IHC Total PV cell number increased [149] Sampedro-Piquero et al.…”

Section: Resultsmentioning

confidence: 99%

“…(2015) Rat (Sprague-Dawley) Early postnatal-adolescent Adolescent ♂♀ MS 4h/day from P2–P20; EE P21–P36 Infralimbic cortex Western blot PV protein content decreased in males [35] do Prado et al. (2015) Rat (Sprague-Dawley) Early postnatal Juvenile; adult ♂ Oral FLX 10 mg/kg/d from P2–P21 Cingulate cortex IHC; WFA stain PV cell density no change [113] Mukhopadhyay et al. (2021) Mouse (C57/BL6) Adolescent-adult Adult ♂ Dried bonito broth (10%) intake 53 days Medial Prefrontal cortex IHC PV cell density increased [74] Jargalsaikhan et al.…”

Section: Resultsmentioning

confidence: 99%

“…(2020) Rat (Sprague-Dawley) Adolescent Adolescent ♂ R- or S-ketamine 10 mg/kg IP; sacrifice 30 min later Dentate Gyrus IHC PV cell density decreased by S-ketamine [186] Yang et al. (2015) Rat (Sprague-Dawley) Early postnatal Juvenile; adult ♂ Oral FLX 10 mg/kg/d from P2–P21 Dentate Gyrus IHC; WFA stain Total PV cell number; PNN + fraction of PV cells no change [113] Mukhopadhyay et al. (2021) Mouse (C57/BL6) Prenatal, early postnatal Early postnatal; juvenile ♂♀ Mothers given oral FLX 11.3 mg/kg/d from GD7-P7 Dentate Gyrus IHC; WHA stain Total PV cell number; PV+/PNN + cell number; PV intensity in PV+/PNN + cells no change [172] Umemori et al.…”

Section: Resultsmentioning

confidence: 99%

“…PNNs are established during postnatal development and their maturation is intimately associated with the opening and closure of critical periods of enhanced neuroplasticity ( Wen et al., 2018 ). Recent evidence suggests that PNNs on PV neurons may be altered by early life stress in animals ( Gildawie et al., 2019 ; Mukhopadhyay et al., 2021 ) and humans ( Tanti et al., 2020 ), which are thought to reflect changes in PV cell excitability, plasticity, oxidative stress, and other metabolic functions ( Wen et al., 2018 ). PNNs are typically labeled using a lectin called Wisteria floribunda lectin (WFL) or agglutinin (WFA), which binds a carbohydrate residue found in PNNs, in particular those surrounding PV neurons.…”

Section: Methodsmentioning

confidence: 99%

“…In this review, we included treatment with antidepressant drugs such as fluoxetine and ketamine as enrichment protocols because of their use in treating stress-related mood disorders in humans. One notable example of enrichment impacting PV neurons is that of fluoxetine's effect on PNNs; numerous studies have demonstrated chronic fluoxetine treatment to reduce the densities of PNNs and PV cells in the HC ( Karpova et al., 2011 ; Mukhopadhyay et al., 2021 ), PFC ( Guirado et al., 2014 ; Ohira et al., 2013 ), and BLA ( Karpova et al., 2011 ). Making PV cell dendrites more freely accessible for the formation and elimination of synapses may be one of the mechanisms underlying the antidepressant effects of fluoxetine.…”

Section: Introductionmentioning

confidence: 99%

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Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review

Perlman¹,

Tanti²,

Mechawar³

2021

Neurobiology of Stress

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Stress-related psychiatric disorders including depression involve complex cellular and molecular changes in the brain, and GABAergic signaling dysfunction is increasingly implicated in the etiology of mood disorders. Parvalbumin (PV)-expressing neurons are fast-spiking interneurons that, among other roles, coordinate synchronous neuronal firing. Mounting evidence suggests that the PV neuron phenotype is altered by stress and in mood disorders. In this systematic review, we assessed PV interneuron alterations in psychiatric disorders as reported in human postmortem brain studies and animal models of environmental stress. This review aims to 1) comprehensively catalog evidence of PV cell function in mood disorders (humans) and stress models of mood disorders (animals); 2) analyze the strength of evidence of PV interneuron alterations in various brain regions in humans and rodents; 3) determine whether the modulating effect of antidepressant treatment, physical exercise, and environmental enrichment on stress in animals associates with particular effects on PV function; and 4) use this information to guide future research avenues. Its principal findings, derived mainly from rodent studies, are that stress-related changes in PV cells are only reported in a minority of studies, that positive findings are region-, age-, sex-, and stress recency-dependent, and that antidepressants protect from stress-induced apparent PV cell loss. These observations do not currently translate well to humans, although the postmortem literature on the topic remains limited.

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