Postnatal neurogenesis in the medial cortex of the tropical lizard Tropidurus hispidus

Marchioro, Murilo; Nunes, João M.; Ramalho, A.M. Rabelo; Molowny, A.; Esther, Pérez-Martínez; Ponsoda, Xavier; López‐García, Carlos

doi:10.1016/j.neuroscience.2005.04.014

Cited by 30 publications

(38 citation statements)

References 19 publications

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“…However, there is a considerable species difference in the number of cells that migrate along radial glia. In the cortex of the tropical lizard Tropidurus, less than 30% of the proliferating cells migrate along radial glia in contrast to 90% in the European lizard Podacris (Lopez-Garcia et al 1990;Marchioro et al 2005). It takes 1-2 weeks for the cells to migrate and differentiate into neurons in the cortex of Podarcis and Tropidurus (Lopez-Garcia et al 1990;Ramirez-Castillejo et al 2002;Marchioro et al 2005).…”

Section: (D) Reptilesmentioning

confidence: 99%

“…In the cortex of the tropical lizard Tropidurus, less than 30% of the proliferating cells migrate along radial glia in contrast to 90% in the European lizard Podacris (Lopez-Garcia et al 1990;Marchioro et al 2005). It takes 1-2 weeks for the cells to migrate and differentiate into neurons in the cortex of Podarcis and Tropidurus (Lopez-Garcia et al 1990;Ramirez-Castillejo et al 2002;Marchioro et al 2005). Only a few or no degenerating cells have been found in the brain of reptiles and thus most of the cells produced seem to survive for long times (Lopez-Garcia et al 1990;Font et al 2001).…”

Section: (D) Reptilesmentioning

confidence: 99%

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Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Kaslin

Ganz

Brand

2007

Phil. Trans. R. Soc. B

319

302

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Post-embryonic neurogenesis is a fundamental feature of the vertebrate brain. However, the level of adult neurogenesis decreases significantly with phylogeny. In the first part of this review, a comparative analysis of adult neurogenesis and its putative roles in vertebrates are discussed. Adult neurogenesis in mammals is restricted to two telencephalic constitutively active zones. On the contrary, non-mammalian vertebrates display a considerable amount of adult neurogenesis in many brain regions. The phylogenetic differences in adult neurogenesis are poorly understood. However, a common feature of vertebrates (fish, amphibians and reptiles) that display a widespread adult neurogenesis is the substantial post-embryonic brain growth in contrast to birds and mammals. It is probable that the adult neurogenesis in fish, frogs and reptiles is related to the coordinated growth of sensory systems and corresponding sensory brain regions. Likewise, neurons are substantially added to the olfactory bulb in smell-oriented mammals in contrast to more visually oriented primates and songbirds, where much fewer neurons are added to the olfactory bulb. The second part of this review focuses on the differences in brain plasticity and regeneration in vertebrates. Interestingly, several recent studies show that neurogenesis is suppressed in the adult mammalian brain. In mammals, neurogenesis can be induced in the constitutively neurogenic brain regions as well as ectopically in response to injury, disease or experimental manipulations. Furthermore, multipotent progenitor cells can be isolated and differentiated in vitro from several otherwise silent regions of the mammalian brain. This indicates that the potential to recruit or generate neurons in non-neurogenic brain areas is not completely lost in mammals. The level of adult neurogenesis in vertebrates correlates with the capacity to regenerate injury, for example fish and amphibians exhibit the most widespread adult neurogenesis and also the greatest capacity to regenerate central nervous system injuries. Studying these phenomena in non-mammalian vertebrates may greatly increase our understanding of the mechanisms underlying regeneration and adult neurogenesis. Understanding mechanisms that regulate endogenous proliferation and neurogenic permissiveness in the adult brain is of great significance in therapeutical approaches for brain injury and disease.

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Section: (D) Reptilesmentioning

confidence: 99%

Section: (D) Reptilesmentioning

confidence: 99%

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Kaslin

Ganz

Brand

2007

Phil. Trans. R. Soc. B

319

302

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“…Reptilian ependymal cells lining the ventricular wall proliferate continuously, generating new neurons that integrate into established circuits (Lopez-Garcia et al, 2002;Marchioro et al, 2005). The ependymal regions associated with highest proliferative capacity are referred to as the sulcus lateralis, sulcus septomedialis, sulcus ventralis, and sulcus terminalis located along the lateral ventricles (Kirsche, 1967;Schultz, 1969;Tineo et al, 1987;Yanes-Méndez et al, 1988) The third, tectal and fourth ventricles may also be a source of new neurons and should be investigated further (personal observation; Margotta et al, 1999;Saijo, 2007).…”

Section: Proliferationmentioning

confidence: 99%

“…Furthermore, only one reptilian study investigates regional differences in neurogenesis over the organism's lifespan (Marchioro et al, 2005).…”

Section: Future Studies Of Adult Neurogenesis In Reptilesmentioning

confidence: 99%

“…Several previous studies in reptiles have found evidence of DVR cell genesis (Delgado-Gonzalez et al, 2011;Font et al, 2001;Marchioro et al, 2005). The mammalian homologue to the reptilian DVR may be the neocortex, claustroamygdaloid regions, or a combination of both; however, the debate over this homology has elicited controversy in the field of evolutionary biology (Bruce and Neary, 1995;Karten, 1997;Molnár and Butler, 2002;Striedter, 1997).…”

Section: Dvrmentioning

confidence: 99%

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Proliferation, Migration, and Survival of Cells in the Telencephalon of the Ball Python, Python Regius

Bales¹

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Potential Adult Neurogenesis in the Telencephalon and Cerebellar Cortex of the Nile Crocodile Revealed with Doublecortin Immunohistochemistry

Ngwenya

Patzke

Herculano‐Houzel

et al. 2017

The Anatomical Record

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The brain of the crocodile is known to gain in mass allometrically throughout life, and the addition of neurons (as well as non-neurons) appears to play a significant role in this increasing brain mass. We used immunohistochemistry in the brains of 12 Nile crocodiles ranging between 350 g and 86 kg in body mass and 1.99 g to 7.9 g in brain mass to identify the regions of the brain in which neurons immunopositive for doublecortin (DCX), a marker for potential adult neurogenesis, are found. Similar to other reptiles, potential newly born neurons, those immunopositive for DCX, were found throughout the telencephalon, the main and accessory olfactory bulbs and the olfactory tract, and in the cerebellar cortex; however, no DCX immunopositive neurons were observed in the diencephalon or brainstem. An apparent moderate decrease in the density of DCX labeled neurons in the olfactory bulbs and tract as well as the cerebellar cortex was observed with increasing brain mass, but the observed qualitative density of labeled neurons within the telencephalon was maintained irrespective of brain mass. Three potential neurogenic zones, within the sulci of the lateral ventricle, were identified, and these are similar to those seen in other reptiles. This study indicates that at least part of the gain in brain mass with age in the Nile crocodile may be accounted for by the potential addition and integration of new neurons into the existing circuitry, especially so for the olfactory system, telencephalon and cerebellar cortex. Anat Rec, 301:659-672, 2018. © 2017 Wiley Periodicals, Inc.

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Postnatal neurogenesis in the medial cortex of the tropical lizard Tropidurus hispidus

Cited by 30 publications

References 19 publications

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Proliferation, Migration, and Survival of Cells in the Telencephalon of the Ball Python, Python Regius

Potential Adult Neurogenesis in the Telencephalon and Cerebellar Cortex of the Nile Crocodile Revealed with Doublecortin Immunohistochemistry

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