Postnatal ontogenesis of hippocampal CA1 area in rats. I. Development of dendritic arborisation in pyramidal neurons

Pokorný, J; Yamamoto, Takeyuki

doi:10.1016/0361-9230(81)90075-7

Cited by 242 publications

(148 citation statements)

References 30 publications

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“…S1 A-C), there were no obvious differences in gross morphology and projections of hippocampal layers between Nestin-Wnt5a fl/fl mice and control Wnt5a fl/fl littermates at 1 mo (Fig. S1E), when hippocampal neural circuit establishment should be complete (29)(30)(31). Detailed examination of dendritic morphology of CA1 hippocampal pyramidal neurons revealed normal dendrite length, complexity, and spine densities in 1-mo-old mutant mice (Fig.…”

Section: Resultsmentioning

confidence: 92%

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Chen

Orefice

Chiu

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Stability of neuronal connectivity is critical for brain functions, and morphological perturbations are associated with neurodegenerative disorders. However, how neuronal morphology is maintained in the adult brain remains poorly understood. Here, we identify Wnt5a, a member of the Wnt family of secreted morphogens, as an essential factor in maintaining dendritic architecture in the adult hippocampus and for related cognitive functions in mice. Wnt5a expression in hippocampal neurons begins postnatally, and its deletion attenuated CaMKII and Rac1 activity, reduced GluN1 glutamate receptor expression, and impaired synaptic plasticity and spatial learning and memory in 3-mo-old mice. With increased age, Wnt5a loss caused progressive attrition of dendrite arbors and spines in Cornu Ammonis (CA)1 pyramidal neurons and exacerbated behavioral defects. Wnt5a functions cell-autonomously to maintain CA1 dendrites, and exogenous Wnt5a expression corrected structural anomalies even at late-adult stages. These findings reveal a maintenance factor in the adult brain, and highlight a trophic pathway that can be targeted to ameliorate dendrite loss in pathological conditions. autocrine Wnt signaling | dendrite arbors | adult hippocampus

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Section: Resultsmentioning

confidence: 92%

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Chen

Orefice

Chiu

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…Synaptic development in the hippocampus is determined by a process that occurs in the first 3-4 weeks after birth (32,33). Indeed, the time course of synaptic formation and the onset of long-term potentiation in organotypic hippocampal culture from 2 to 8-day-old rats were examined in detail by measuring evoked field population spikes (12), which suggested that the responses reached a plateau level within 10-15 days.…”

Section: Resultsmentioning

confidence: 99%

Basic Fibroblast Growth Factor and Brain-Derived Neurotrophic Factor Promote Survival and Neuronal Circuit Formation in Organotypic Hippocampal Culture

Nakagami

Saito

Matsuki

1997

Japanese Journal of Pharmacology

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ABSTRACT-Neurotrophic effects in vitro have been generally related to promotion of differentiation, maturation and survival, but little is known about the effect on neuronal circuit formation. The organotypic culture system would be an available technique to investigate neuronal circuit formation and neuronal cell-cell interactions. As we reported previously, an optical recording system is a useful technique to com prehend neuronal activities and circuit from multi-points simultaneously. In this study, we investigated whether continuous application of basic fibroblast growth factor (bFGF or FGF-2) and brain-derived neuro trophic factor (BDNF) inhibited neuronal cell death induced by serum-deprivation in organotypic culture using propidium iodide staining, and we analyzed effects of bFGF and BDNF on the formation of neuronal circuits using the optical recording system. Continuous application of bFGF or BDNF significantly pro tected the slices from neuronal death. Optical recording also demonstrated that addition of 10 ng/ml bFGF or 50 ng/ml BDNF enhanced optical signals in all hippocampal areas significantly. These data strongly suggest that bFGF and BDNF promote the formation of neuronal circuits as well as survival and that op tical recording of organotypic hippocampal slices would be a useful technique that enables us to analyze neuronal circuit formation easily.

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“…Maternal care, CA1 neuronal morphology, and synaptic function Previous studies suggest effects of early experience on neuronal morphology and synaptic function in the hippocampus (Poeggel et al, 2003;Ovtscharoff et al, 2006), including effects of postnatal "handling" on hippocampal LTP (Wilson et al, 1986;Tang and Zou, 2002). Such effects occur during hippocampal maturation (Pokorny and Yamamoto, 1981;Turner et al, 1998). Although migration of pyramidal neurons is complete at birth, there is a burst of postnatal growth that includes increases in synapse and spine number (Turner et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress

Champagne¹,

Bagot²,

Hasselt³

et al. 2008

Journal of Neuroscience

599

478

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Maternal licking and grooming (LG) in infancy influences stress responsiveness and cognitive performance in the offspring. We examined the effects of variation in the frequency of pup LG on morphological, electrophysiological, and behavioral aspects of hippocampal synaptic plasticity under basal and stress-like conditions. We found shorter dendritic branch length and lower spine density in CA1 cells from the adult offspring of low compared with high LG offspring. We also observed dramatic effects on long-term potentiation (LTP) depending on corticosterone treatment. Low LG offspring, in contrast to those of high LG mothers, displayed significantly impaired LTP under basal conditions but surprisingly a significantly enhanced LTP in response to high corticosterone in vitro. This enhanced plasticity under conditions that mimic those of a stressful event was apparent in vivo. Adult low LG offspring displayed enhanced memory relative to high LG offspring when tested in a hippocampal-dependent, contextual fear-conditioning paradigm. Hippocampal levels of glucocorticoid and mineralocorticoid receptors were reduced in low compared with high LG offspring. Such effects, as well as the differences in dendritic morphology, likely contribute to LTP differences under resting conditions, as well as to the maternal effects on synaptic plasticity and behavior in response to elevated corticosterone levels. These results suggest that maternal effects may modulate optimal cognitive functioning in environments varying in demand in later life, with offspring of high and low LG mothers showing enhanced learning under contexts of low and high stress, respectively.

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Postnatal ontogenesis of hippocampal CA1 area in rats. I. Development of dendritic arborisation in pyramidal neurons

Cited by 242 publications

References 30 publications

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice

Basic Fibroblast Growth Factor and Brain-Derived Neurotrophic Factor Promote Survival and Neuronal Circuit Formation in Organotypic Hippocampal Culture

Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress

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