Postnatal ontogeny of dopamine D2 receptors in rat striatum

Lc, Murrin; Zeng, Wanyun

doi:10.1016/0006-2952(86)90154-1

Cited by 76 publications

(20 citation statements)

References 19 publications

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“…Additionally, the ontogenetic profile of DA receptor expression has been characterized in the rat striatum. There is a constant increase in DA receptor densities throughout development which peak at about PND 28-30 [47,48,60,78]. Further evidence shows that striatal DA receptors are overexpressed before the onset of puberty, peak at around PND 40 and then decrease to adult levels [3,73].…”

Section: Introductionmentioning

confidence: 89%

Cocaine during adolescence enhances dopamine in response to a natural reinforcer

Catlow

Kirstein

2007

Neurotoxicology and Teratology

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The use of cocaine during adolescent development could alter the normal growth of brain regions affected by cocaine, specifically the reward system, and impact the adult mesolimbic system. However, there is scant literature aimed at determining whether animals are more vulnerable to the adverse effects of drugs during adolescence. The present study investigated whether cocaine pretreatment in either adolescence or adulthood altered the dopaminergic response to a naturally reinforcing substance in adulthood. To evaluate the responsivity of the mesolimbic system after repeated cocaine, sucrose was offered during the dialysis procedure and dialysates were collected. Regardless of age all saline pretreated rats had significant increases in sucrose-induced extracellular dopamine (DA) levels in the nucleus accumbens septi (NAcc) as compared to baseline levels. Rats pretreated with cocaine as adults also had significant increases in DA levels after sucrose. Interestingly, sucrose intake significantly enhanced DA levels in cocaine pretreated adolescent rats as compared to all other conditions. The results from the present study show that in rats pretreated with cocaine during adolescence there is an enhanced response of the dopaminergic system in animals exposed to a naturally reinforcing substance. Therefore, cocaine exposure during adolescence results in long-term functional changes in the mesolimbic pathway. Future studies need to ascertain the underlying mechanisms and their potential role in cocaine addiction.

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Section: Introductionmentioning

confidence: 89%

Cocaine during adolescence enhances dopamine in response to a natural reinforcer

Catlow

Kirstein

2007

Neurotoxicology and Teratology

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“…Firing rates of nigrostriatal neurons increase gradually [167,212]. Dopamine D1 and D2 receptor density increases in a linear fashion during the first 4 weeks of life and reach their adult-like density at this stage [159,163,176].…”

Section: Postnatal Brain Developmentmentioning

confidence: 98%

Trajectories of brain development: point of vulnerability or window of opportunity?

Andersen

2003

Neuroscience & Biobehavioral Reviews

1,325

1,006

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Brain development is a remarkable process. Progenitor cells are born, differentiate, and migrate to their final locations. Axons and dendrites branch and form important synaptic connections that set the stage for encoding information potentially for the rest of life. In the mammalian brain, synapses and receptors within most regions are overproduced and eliminated by as much as 50% during two phases of life: immediately before birth and during the transitions from childhood, adolescence, to adulthood. This process results in different critical and sensitive periods of brain development. Since Hebb (1949) first postulated that the strengthening of synaptic elements occurs through functional validation, researchers have applied this approach to understanding the sculpting of the immature brain. In this manner, the brain becomes wired to match the needs of the environment. Extensions of this hypothesis posit that exposure to both positive and negative elements before adolescence can imprint on the final adult topography in a manner that differs from exposure to the same elements after adolescence. This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome. q

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“…The binding and mRNA data were taken only from the CPu. In figure 6 a, the percent of ligand binding for either D1 or D2 receptors is compared to adult [Murrin and Zeng, 1986;Zeng et al, 1988;Gelbard et al, 1989;Sales et al, 1989;Murrin and Zeng, 1990;Rao et al, 1991;Crawford et al, 1994;Schambra et al, 1994;Flores et al, 1996;Jung and Bennett, 1996;Johansson et al, 1997;Stanwood et al, 1997;du Bois et al, 2008]. In general, there is an increase in D1 and D2 receptor binding as the animal grows, with little difference between the D1 and D2 curves.…”

Section: Meta-analysis Of Literature Datamentioning

confidence: 99%

Pharmacologic Neuroimaging of the Ontogeny of Dopamine Receptor Function

Chen

Choi

et al. 2010

Dev Neurosci

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Characterization of the ontogeny of the cerebral dopaminergic system is crucial for gaining a greater understanding of normal brain development and its alterations in response to drugs of abuse or conditions such as attention-deficit hyperactivity disorder. Pharmacological MRI (phMRI) was used to determine the response to dopamine transporter (DAT) blockers cocaine and methylphenidate (MPH), the dopamine releaser D-amphetamine (AMPH), the selective D1 agonist dihydrexidine, and the D2/D3 agonist quinpirole in young (<30 days old) and adult (>60 days old) rats. In adult rats, cocaine (0.5 mg/kg i.v.) or MPH (2 mg/kg) induced primarily positive cerebral blood volume (rCBV) changes in the dopaminergic circuitry, but negative rCBV changes in the young animals. Microdialysis measurements in the striatum showed that young rats have a smaller increase in extracellular dopamine in response to cocaine than adults. The young rats showed little rCBV response to the selective D1 agonist dihydrexidine in contrast to robust rCBV increases observed in the adults, whereas there was a similar negative rCBV response in the young and adult rats to the D2 agonist quinpirole. We also performed a meta-analysis of literature data on the development of D1 and D2 receptors and the DAT. These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age.

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Postnatal ontogeny of dopamine D2 receptors in rat striatum

Cited by 76 publications

References 19 publications

Cocaine during adolescence enhances dopamine in response to a natural reinforcer

Cocaine during adolescence enhances dopamine in response to a natural reinforcer

Trajectories of brain development: point of vulnerability or window of opportunity?

Pharmacologic Neuroimaging of the Ontogeny of Dopamine Receptor Function

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