Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer

Lee, Jun Young; Kim, Sung‐Bae; Lee, Hyun Jung; Park, Soo Jung; Hong, Sung Pil; Cheon, Jae Hee; Kim, Tae Il

doi:10.1016/j.gie.2017.04.004

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…First, video-based interventions may be integrated into existing endoscopic training curricula 18 19 33 to facilitate recognition of performance deficits among novices. Video-recording has demonstrated benefits as a tool for external assessment and debriefing 34 , and, based on our findings, it may also be used to improve learning by promoting accurate self-assessment. Ensuring trainees have accurate perceptions of their endoscopic competence may facilitate their learning as several studies in the educational literature have demonstrated that trainees are more receptive to feedback and more likely to uptake external feedback if it aligns with their self-perception 35 36 .…”

Section: Discussionmentioning

confidence: 68%

Influence of video-based feedback on self-assessment accuracy of endoscopic skills: a randomized controlled trial

et al. 2019

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Background and study aims Novice endoscopists are inaccurate in self-assessment of procedures. One means of improving self-assessment accuracy is through video-based feedback. We aimed to determine the comparative effectiveness of three video-based interventions on novice endoscopists’ self-assessment accuracy of endoscopic competence. Materials and methods Novice endoscopists (performed < 20 previous procedures) were recruited. Participants completed a simulated esophagogastroduodenoscopy (EGD) on a virtual reality simulator. They were then randomized to one of three groups: self-video review (SVR), which involved watching a recorded video of their own performance; benchmark review (BVR), which involved watching a video of a simulated EGD completed by an expert; and self- and benchmark video (SBVR), which involved both videos. Participants then completed two additional simulated EGD cases. Self-assessments were conducted immediately after the first procedure, after the video intervention and after the additional two procedures. External assessments were conducted by two experienced endoscopists, who were blinded to participant identity and group assignment through video recordings. External and self-assessments were completed using the global rating scale component of the Gastrointestinal Endoscopy Competency Assessment Tool (GiECAT GRS). Results Fifty-one participants completed the study. The BVR group had significantly improved self-assessment accuracy in the short-term, compared to the SBVR group (P = .005). The SBVR group demonstrated significantly improved self-assessment accuracy over time (P = .016). There were no significant effects of group or of time for the SVR group. Conclusions Video-based interventions, particularly combined use of self- and benchmark video review, can improve accuracy of self-assessment of endoscopic competence among novices.

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Section: Discussionmentioning

confidence: 68%

Influence of video-based feedback on self-assessment accuracy of endoscopic skills: a randomized controlled trial

et al. 2019

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“…Jamall: 4open 2019, 2, 9 neoadjuvant to radiochemotherapy in rectal cancer [151]. Aspirin was shown to be effective in the precancerous adenomatosis polyposis coli or APC [152] and in terms of adenoma prior to CRC [153]. Effective aspirin use against cancers had been shown in ovarian [154,155], stomach [156][157][158], pancreas [159,160], hepatocellular carcinoma (HCC) [161], breast [162,163], prostate [164][165][166], melanoma [167] and mesothelioma [168].…”

Section: Eicosanoidsmentioning

confidence: 99%

Eicosanoids in carcinogenesis

Brücher

Jamall

2019

4open

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Inflammation is the body's reaction to pathogenic (biological or chemical) stimuli and covers a burgeoning list of compounds and pathways that act in concert to maintain the health of the organism. Eicosanoids and related fatty acid derivatives can be formed from arachidonic acid and other polyenoic fatty acids via the cyclooxygenase and lipoxygenase pathways generating a variety of pro- and anti-inflammatory mediators, such as prostaglandins, leukotrienes, lipoxins, resolvins and others. The cytochrome P450 pathway leads to the formation of hydroxy fatty acids, such as 20-hydroxyeicosatetraenoic acid, and epoxy eicosanoids. Free radical reactions induced by reactive oxygen and/or nitrogen free radical species lead to oxygenated lipids such as isoprostanes or isolevuglandins which also exhibit pro-inflammatory activities. Eicosanoids and their metabolites play fundamental endocrine, autocrine and paracrine roles in both physiological and pathological signaling in various diseases. These molecules induce various unsaturated fatty acid dependent signaling pathways that influence crosstalk, alter cell–cell interactions, and result in a wide spectrum of cellular dysfunctions including those of the tissue microenvironment. Although the complete role of eicosanoids, including that of the recently elucidated anti-inflammatory specialized pro-resolving lipid mediators (SPMs), e.g. lipoxins, resolvins, protectins and maresins, is not completely understood, the result of unremitting chronic inflammation is fostering early stages of carcinogenesis. Chronic inflammation facilitates the transition from a normal cell to a cancerous one. The disruption of homeostasis across a wide, but identifiable, swath of diverse molecular pathways creates a micromilieu which constitutes an early and necessary step in the 6-step sequence of carcinogenesis for the vast majority of cancers, termed “sporadic cancers”.

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A case of an enlarged rectal adenoma while achieving a clinical complete response with chemotherapy for advanced rectal cancer

Nakamura

Koyama

Morita

et al. 2020

Clin J Gastroenterol

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Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer

Cited by 4 publications

References 24 publications

Influence of video-based feedback on self-assessment accuracy of endoscopic skills: a randomized controlled trial

Influence of video-based feedback on self-assessment accuracy of endoscopic skills: a randomized controlled trial

Eicosanoids in carcinogenesis

A case of an enlarged rectal adenoma while achieving a clinical complete response with chemotherapy for advanced rectal cancer

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