Postoperative administration of ketorolac compared to other drugs for pain control after third molar surgery: A meta‐analysis of double‐blind, randomized, clinical trials

Isiordia-Espinoza, Mario Alberto; Alonso-Castro, Ángel Josabad; Serafín-Higuera, Nicolás; Castañeda-Santana, Demian Ismael; Coronado, Maximiliano de la Rosa; Bologna‐Molina, Ronell

doi:10.1111/bcp.15241

Cited by 6 publications

(7 citation statements)

References 52 publications

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“…However, Tirupathi et al conducted a review study and concluded that further clinical trials were needed to prove the effectiveness of ketorolac in pain control ( 24 ). By contrast, Isiordia et al showed that the administration of 30 mg ketorolac, compared to 1 - 10 mg parecoxib, after the surgical removal of third molars resulted in better analgesic effects and higher patient satisfaction ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

et al. 2023

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Background: Postoperative pain management is one of the major challenges of surgeons and anesthesiologists. Objectives: This study aimed to determine the efficacy of topical ketorolac in post-hemorrhoidectomy pain management. Methods: This clinical trial was conducted on 84 candidates for hemorrhoidectomy (grade-II hemorrhoids) who visited Ali ibn Abi-Talib hospital of Rafsanjan, Kerman, Iran (2020 - 2021). The participants were selected through convenience sampling and randomly assigned to three groups of 28. The subjects were treated in topical (4 mL 0.5% Marcaine + 1 mL ketorolac at the surgical site), intramuscular (4 mL 0.5% Marcaine at the surgical site + 1 mL ketorolac intramuscularly), and control (4 mL 0.5% Marcaine at the surgical site) groups. Pain intensity was measured using the Numerical Pain Rating Scale 1, 6, 12, and 24 hours after surgery. The obtained data were analyzed using two-way repeated measures analysis of variance. Results: Female and male patients constituted 46.4% and 53.6% of the participants, respectively. The mean pain intensity was significantly lower in the topical group than in intramuscular and control treatments in all four stages of pain assessment (P < 0.001). Some participants were treated with pethidine due to high pain intensity. However, the mean pain intensity gradually reduced over time in all three groups. Conclusions: Study findings suggested that the topical administration of ketorolac and Marcaine was more effective than Marcaine used alone for relieving pain in patients undergoing hemorrhoidectomy.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

et al. 2023

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“…The Cochrane Collaboration’s risk of bias tool was used to determine the risk of bias in all studies that met the inclusion criteria [ 1 , 2 , 3 , 4 , 37 , 38 , 39 ]. Two independent investigators assessed the risk of bias.…”

Section: Methodsmentioning

confidence: 99%

“…Two independent investigators assessed the risk of bias. The differences between their evaluations were discussed until a consensus was reached [ 1 , 2 , 3 , 4 , 37 , 38 , 39 ]. The clinical reports with a high risk of bias were excluded (at least one red ball).…”

Section: Methodsmentioning

confidence: 99%

“…Data were analyzed with the inverse variance statistical method, mean difference, and fixed effects using the Review Manager Software 5.3 for Windows. A global test with a p-value lower than 0.05 of the mean difference and an OR (>1 and within the 95% confidence intervals (95% CI)) were considered statistically significant [ 1 , 2 , 3 , 4 , 37 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

“…Several drugs have been used for postoperative complications control following third molar removal [ 1 , 2 , 3 , 4 ]. The most used drugs are non-steroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, and corticosteroids [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis

González-Morelos¹,

Torre²,

Franco-González³

et al. 2022

Healthcare

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The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selection criteria and with high methodological quality, according to the Cochrane Collaboration’s risk of bias tool, were included in this study. The inverse variance test and mean difference using the Review Manager Software 5.3 for Windows were used to carry out data analysis. Qualitative analysis shows that methylprednisolone is more effective than NSAIDs, but inferior to dexamethasone, for controlling postoperative complications after third molar removal. The quantitative analysis showed no statistical difference for pain control, while trismus evaluation showed a statistical difference after 7 postoperative days in favor of methylprednisolone, when compared to other drugs. In conclusion, methylprednisolone was more effective for trismus control compared to other drugs after lower third molar surgery.

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Patient's perception of recovery following surgical removal of mandibular third molars. A prospective european multi-center study

Starch- Jensen,

Gacic,

Konstantinovic

et al. 2023

Journal of Cranio-Maxillofacial Surgery

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Postoperative administration of ketorolac compared to other drugs for pain control after third molar surgery: A meta‐analysis of double‐blind, randomized, clinical trials

Cited by 6 publications

References 52 publications

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis

Patient's perception of recovery following surgical removal of mandibular third molars. A prospective european multi-center study

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