Postoperative Alterations in Taste and Smell

Elterman, Kelly; Mallampati, S. Rao; Kaye, Alan D.; Urman, Richard D.

doi:10.5812/aapm.18527

Cited by 16 publications

(8 citation statements)

References 16 publications

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“…However, one patient had a post‐traumatic loss, and one from a postanesthetic smell loss. Postanesthetic smell loss, although exceedingly rare, has been reported in the literature and can be permanent with a direct temporal relationship following general anesthesia . This etiology has been seen multiple times in our own smell loss center related to anesthesia for surgeries for areas far away from the head and neck region.…”

Section: Discussionmentioning

confidence: 76%

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

Yan

Mundy

Patel

2020

Laryngoscope Investig Oto

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Background: Olfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Plateletrich plasma (PRP) is an autologous biologic product with anti-inflammatory and neuroprotective effects. This novel pilot study evaluated the role of PRP on olfactory neuroregeneration in patients with hyposmia.Methods: Seven patients who had olfactory loss greater than 6 months in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study.Patients received a single intranasal injection of PRP into the mucosa of the olfactory cleft. The Sniffin' Sticks olfactory test consisting of threshold, discrimination, and identification measurements (TDI) was administered at the beginning of the study and at 1 and 3 months.Results: All patients reported a subjective improvement of their smell shortly after injection but then stabilized. At 3-month post-treatment, two patients with functional anosmia (TDI < 16) did not improve significantly. Five patients with hyposmia (TDI > 16 but <30) showed an improvement with 60% achieving normosmia (TDI > 30) at 3-month follow-up. On average, patients with baseline TDI > 16 improved by 5.85 points with the most significant improvement in the threshold subcomponent. There were no adverse outcomes from intranasal PRP injections.Conclusion: PRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use.

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Section: Discussionmentioning

confidence: 76%

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

Yan

Mundy

Patel

2020

Laryngoscope Investig Oto

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“…Concurrent affectation of the sense of taste suggests that most probably ageusia in these patients is secondary to a diminished taste perception as a consequence of anosmia. However, sensorineural impairment due to direct viral injury cannot be entirely excluded (Elterman et al 2014 ; Rahban et al 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Ageusia and anosmia, a common sign of COVID-19? A case series from four countries

Vargas-Gandica¹,

Winter²,

Schnippe³

et al. 2020

J. Neurovirol.

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Over the course of the pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), multiple new clinical manifestations, as the consequence of the tropism of the virus, have been recognized. That includes now the neurological manifestations and conditions, such as headache, encephalitis, as well as olfactory and taste disorders. We present a series of ten cases of RT-PCR-confirmed SARS-CoV-2-infected patients diagnosed with viral-associated olfactory and taste loss from four different countries.

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“…Inhaled halogenates can nevertheless be the ones mostly affecting the sense of smell because they also collide with the posterodorsal olfactory epithelium of the nasal cavity that houses the odorant receptors (cranial nerve I). Importantly, these sensory neurons play a fundamental role in driving eating behaviors, and subjects with sniffing impairment can decide to alter their diet to compensate for the loss ( 6 ). In fact, the smelling of palatable food aromas promotes appetite, liking, and food intake ( 7 , 8 ), especially in restrained eaters ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Perioperative Anesthesia and Acute Smell Alterations in Spine Surgery: A “Sniffing Impairment” Influencing Refeeding?

et al. 2022

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Medications for general anesthesia can cause smell alterations after surgery, with inhalation anesthetics being the most acknowledged drugs. However, spine patients have been poorly studied in past investigations and whether these alterations could influence the refeeding remains unclear. This research aims to observe detectable dysosmias after spine surgery, to explore any amplified affection of halogenates (DESflurane and SEVoflurane) against total intravenous anesthesia (TIVA), and to spot potential repercussions on the refeeding. Fifty patients between 50 and 85 years old were recruited before elective spine procedure and tested for odor acuity and discrimination using the Sniffin' Sticks test. The odor abilities were re-assessed within the first 15 h after surgery together with the monitoring of food intakes. The threshold reduced from 4.92 ± 1.61 to 4.81 ± 1.64 (p = 0.237) and the discrimination ability reduced from 10.50 ± 1.83 to 9.52 ± 1.98 (p = 0.0005). Anesthetic-specific analysis showed a significant reduction of both threshold (p = 0.004) and discrimination (p = 0.004) in the SEV group, and a significant reduction of discrimination abilities (p = 0.016) in the DES group. No dysosmias were observed in TIVA patients after surgery. Food intakes were lower in the TIVA group compared to both DES (p = 0.026) and SEV (p = 0.017). The food consumed was not associated with the sniffing impairment but appeared to be inversely associated with the surgical time. These results confirmed the evidence on inhalation anesthetics to cause smell alterations in spine patients. Furthermore, the poor early oral intake after complex procedures suggests that spinal deformity surgery could be a practical challenge to early oral nutrition.

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Postoperative Alterations in Taste and Smell

Cited by 16 publications

References 16 publications

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

Ageusia and anosmia, a common sign of COVID-19? A case series from four countries

Perioperative Anesthesia and Acute Smell Alterations in Spine Surgery: A “Sniffing Impairment” Influencing Refeeding?

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