Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in ovariohysterectomized dogs

Marucio, Rodrigo Luiz; Luna, Stélio Pacca Loureiro; Neto, Francisco José Teixeira; Minto, Bruno Watanabe; Hatschbach, Eduardo

doi:10.2460/javma.233.1.121

Cited by 4 publications

(8 citation statements)

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“…In dogs that underwent ovariohysterectomy, postoperative vomiting was observed in 2 of 10 dogs given neostigmine (10 µg/kg) epidurally, which was not significantly different from the proportion of dogs given morphine (0.1 mg/kg; 1/10), the combination of neostigmine with morphine (0/10), or saline solution (control treatment; 0/10). 11 In the present study, vomiting was observed in 1 dog in the neostigmine group and 0 dogs in the morphineneostigmine group. Results of the present study are in agreement with previous data, which indicated a low incidence of adverse effects following epidural administration of neostigmine and that neostigmine coadministered epidurally with morphine does not increase the incidence of adverse effects induced by the opioid.…”

Section: Discussionsupporting

confidence: 45%

“…1 Rescue analgesia was not required within 24 hours after surgery in any of 10 dogs that received morphine (0.1 mg/kg) epidurally before elective ovariohysterectomy. 11 However, in dogs that underwent orthopedic surgeries of a pelvic limb, the results of postoperative pain scores and rescue analgesia requirements within 24 hours did not differ between dogs that received epidural administration of morphine (0.2 mg/kg) or saline solution. 4 In the present study, duration of analgesia after epidural administration of morphine ranged from 3 to 24 hours following orthopedic surgery in dogs.…”

Section: Discussionmentioning

confidence: 85%

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Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in dogs undergoing orthopedic surgery of the pelvic limbs

Marucio¹,

Monteiro²,

Moroz³

et al. 2014

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 85%

Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in dogs undergoing orthopedic surgery of the pelvic limbs

Marucio¹,

Monteiro²,

Moroz³

et al. 2014

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“…However, the VAS was not sensitive enough to detect differences in pain levels over time in either treatment group. This result is supported by previous studies that failed to detect significant differences in postoperative pain quantification using the VAS in dogs (Hoelzler and others 2005, Marucio and others 2008) and cats (Tobias and others 2006, Benito-de-la-Víbora and others 2008). In addition, scales that are considered extremely subjective, like the VAS, have shown inconsistent results among different observers when used to assess acute pain in dogs (Holton and others 1998).…”

Section: Discussionsupporting

confidence: 88%

Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy

et al. 2015

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The aim of this randomised placebo-controlled, observer-blinded study was to evaluate the analgesic effects of botulinum toxin type A (BoNT-A) as an adjunct for postoperative pain control in dogs. Sixteen dogs undergoing bilateral radical mastectomy for treatment of mammary tumours were enrolled. Twenty-four hours before surgery, the subjects were distributed into two groups of eight dogs each: 7 iu/kg BoNT-A (BoNT-A) or saline (Control) was administered subcutaneously in each mammary gland. Following sedation with intramuscular 0.03 mg/kg acepromazine and 0.3 mg/kg morphine, anaesthesia was induced intravenously with 4 mg/kg propofol and maintained with isoflurane/O2. Postoperative analgesia was evaluated for 72 hours after extubation using the Visual Analogue Scale (VAS) and modified Glasgow Composite Measure Pain Scale (modified-GCMPS). Rescue analgesia was provided with intramuscular morphine (0.5 mg/kg). Data were analysed using analysis of variance, Tukey's test, Mann-Whitney U test and Friedman test (P<0.05). The pain scores were significantly lower in the BoNT-A than in the Control from 8 hours to 60 hours and from 12 hours to 60 hours after extubation, based on the VAS and modified-GCMPS, respectively. Rescue analgesia was required by significantly more dogs in the Control (7/8) compared with the BoNT-A (2/8) (P=0.022). Pre-emptive BoNT-A appears to be effective as an adjuvant for postoperative pain management in dogs undergoing bilateral radical mastectomy.

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“…Epidural methadone in dogs undergoing pelvic limb surgical procedures resulted in greater decreases in the EtISO required to maintain anesthesia compared with the same doses administered intravenously 2 . Other opioids are also used with the same goal, such as fentanyl 3,4 , sufentanil 5,6 , oxymorphone 7 , and especially morphine 1,[8][9][10][11] . Epidural use of morphine has been limited though because of the dose-dependent risk of delayed respiratory depression and/or potential urinary retention requires close monitoring of respiratory patterns, which is not always possible in dogs 11,12 and humans 13 .…”

Section: Introductionmentioning

confidence: 99%

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

Frazílio

DeRossi²,

Jardim³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy. METHODS:Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic. RESULTS:A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose. CONCLUSION:Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs.

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Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in ovariohysterectomized dogs

Cited by 4 publications

References 0 publications

Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in dogs undergoing orthopedic surgery of the pelvic limbs

Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in dogs undergoing orthopedic surgery of the pelvic limbs

Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

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