Postoperative brachytherapy alone for T1-2 N0 squamous cell carcinomas of the oral tongue and floor of mouth with close or positive margins

Interstitial Brachytherapy with Ir-192 Low-Dose-Rate in the Treatment of Primary and Recurrent Cancer the Oral Cavity and Oropharynx

“…This hypothesis holds true for a series reported by Pernot et al [18] employing local tumor excision and interstitial brachytherapy and by another study given recently by Lapeyre et al [15] with major grade 3 sequelae being only in the order of 6% and 3%, respectively. In fact, oncological results in terms of local control were remarkably good with local tumor control rates of 89% and 88.5% in both studies.…”

“…3. Postoperative interstitial brachytherapy either alone (50-60 Gy) or in combination with postoperative external radiotherapy [8,12,14,15,18,19,25] following local excision and neck dissection (50-60 Gy and 23-25 Gy interstitial brachytherapy). Since 1985, it has been the ongoing and continuing policy of our Head and Neck Group at the University of Erlangen to treat patients with resectable cancer of the oral cavity and oropharynx postoperatively by a combination of interstitial brachytherapy with or without external radiotherapy.…”

Curative Brachytherapy for Recurrent/Residual Tongue Cancer

“…Brachytherapy of primary tongue cancer has the advantage of preserving the function of the tongue and providing good posttreatment QoL [5,12,14,21,24], but there have been few reports concerning the effectiveness and complications of the curative radiotherapy for recurrent and/or residual tongue cancer [11,17].…”

Postoperative brachytherapy alone and combined postoperative radiotherapy and brachytherapy boost for squamous cell carcinoma of the oral cavity, with positive or close margins

“…27 After 50 Gy delivered by RT to the primary site, this dose ranges from 10 to 20 Gy. In our experience dose level should be adapted to the pathologic margin (Table 4), and because of the 66% complication rate when the cumulative dose of RT and BRT exceeded 71 Gy, total dose should be 70 Gy or lower.…”

“…When tumor location precludes the use of lead protection, recent innovations such as ''the modified bridge technique'' and ''resin space'' 13,27 should be used. To optimize the dose rate, Peiffert et al 36 demonstrated that pulse dose rate (PDR) BRT is feasible in a series of 30 head and neck carcinomas but probably necessitates the modification of the implantation techniques.…”