Postoperative cardiac surgery outcomes in a statin-native population

Abstract

Background:Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications.Design:This was a retrospective, descriptive, single-center study.Settings:We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center.Patients:A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery.Intervention:Patients were divided into two groups; Group I – statin users and Group II – nonusers.Measurements:Measurements were baseline and follow-up laboratory markers for muscular injury including cardiac muscle and hepatic injuries and renal injuries.Results:The incidence of rhabdomyolysis and elevation of liver enzymes did not differ between both groups. Postoperative atrial fibrillation was significantly lower in the statin group (P = 0.02). In addition, peak cardiac troponin and creatine kinase-MB did not differ significantly in the statin group. Statin-treated group had significant lower length of mechanical ventilation, and length of stay in the Intensive Care Unit and hospital (P = 0.036, 0.04, and 0.027, respectively).Conclusions:Therapy with statin before cardiac surgeries was not associated with high incidence of adverse events.

Association Between Preoperative Statin Use and Respiratory Complications After Noncardiac Surgery: A Retrospective Cohort Analysis

“…Previous work suggests that statin therapy reduces the risk of noncardiovascular complications including pneumonia and infectious complications and shortens postoperative mechanical ventilation, especially after cardiac and vascular surgery. 7–11 However, available evidence with respect to statins and noncardiac surgery, particularly for noncardiac outcomes including respiratory and infectious complications, remains limited. 12,13…”

“…6 Previous work suggests that statin therapy reduces the risk of noncardiovascular complications including pneumonia and infectious complications and shortens postoperative mechanical ventilation, especially after cardiac and vascular surgery. [7][8][9][10][11] However, available evidence with respect to statins and noncardiac surgery, particularly for noncardiac outcomes including respiratory and infectious complications, remains limited. 12,13 We therefore tested the primary hypotheses that intraoperative albuterol use and postoperative respiratory complications are lower in adults having noncardiac surgery who take statins at least 30 days before surgery.…”