Postoperative Complications After Transthoracic Esophagectomy for Cancer of the Esophagus and Gastroesophageal Junction Are Correlated With Early Cancer Recurrence

Lerut, Toni; Moons, Johnny; Coosemans, Willy; Raemdonck, Dirk Van; Leyn, Paul De; Decaluwé, Herbert; Decker, G. Anton; Nafteux, Philippe

doi:10.1097/sla.0b013e3181bdd5a8

Cited by 244 publications

(188 citation statements)

References 15 publications

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“…However, several other studies have concluded that surgical complications have no negative effect on survival rates and that these rates depend exclusively on the pathological stage of the tumor 12. Lerut et al 13. have reported that the modified Clavien classification, in addition to the microscopic residual tumor and extracapsular lymph node involvement, is a useful prognostic indicator of early recurrence and its timing.…”

Section: Introductionmentioning

confidence: 99%

“…have reported that the modified Clavien classification, in addition to the microscopic residual tumor and extracapsular lymph node involvement, is a useful prognostic indicator of early recurrence and its timing. They have noted that achieving esophagectomy without postoperative complications is of utmost importance because of their potential negative effect on early oncological outcomes 13. Recent advances in endoscopic diagnosis and clinical radiology in Japan allow early detection of gastric cancer, and therapeutic strategies have been established in some clinical trials.…”

Section: Introductionmentioning

confidence: 99%

“…Recent advances in endoscopic diagnosis and clinical radiology in Japan allow early detection of gastric cancer, and therapeutic strategies have been established in some clinical trials. D2 lymph node dissection is safely carried out with low mortality and morbidity and provides favorable oncological outcomes 12, 13. However, in clinical practice, postoperative complications do occur, causing some practical problems including longer hospital stay, excessive weight loss with sarcopenia, psychological damage, and delay of adjuvant chemotherapy in advanced cases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Shimada

Fukagawa

Haga

et al. 2017

Annals of Gastroent Surgery

104

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PurposeThe impact of postoperative complications on survival after radical surgery for esophageal, gastric, and colorectal cancers remains controversial. We conducted a systematic review of recent publications to examine the effect of postoperative complications on oncological outcome.MethodsA literature search of PubMed/MEDLINE was performed using the keywords “esophageal cancer,” “gastric cancer,” and “colorectal cancer,” obtaining 27 reports published online up until the end of April 2016. Articles focusing on (i) postoperative morbidity and oncological outcome; and (ii) body mass index (BMI), postoperative morbidity, and oncological outcome, were selected. Univariate and multivariate analyses (Cox proportional hazards model) were performed.ResultsPatients with postoperative complications had significantly poorer long‐term survival than those without complications. Complications were associated with impaired oncological outcomes. The hazard ratios for overall survival were 1.67 (95% confidence interval [CI], 1.31‐2.12), 1.59 (95% CI, 1.13‐2.24), and 1.55 (95% CI, 1.28‐1.87) in esophageal, gastric, and colorectal cancers, respectively. High BMI was associated with postoperative morbidity rate but not with poor oncological outcome. Low BMI was significantly associated with inferior oncological outcome.ConclusionsComplications after radical surgery for esophageal, gastric, and colorectal cancers are associated with patient prognosis. Avoiding such complications might improve the outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Shimada

Fukagawa

Haga

et al. 2017

Annals of Gastroent Surgery

104

View full text Add to dashboard Cite

show abstract

“…The presence of extracapsular nodal invasion is an independent prognostic factor [68,74,75,[78][79][80] and can be used to stratify patients according to the number of lymph nodes in which it is present. For example, in patients with extracapsular lymph node infiltration in only one lymph node, the median survival is M A N U S C R I P T…”

Section: Prognostic Implications Of Extracapsular Diseasementioning

confidence: 99%

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Kayani

Zacharakis

Ahmed

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Oesophageal cancer is the seventh most common cause of cancer-related death in the developed world and the incidence of oesophageal adenocarcinoma is now the fastest growing of any gastrointestinal cancer. Lymph node involvement is the single most important prognostic factor in oesophageal cancer. Imaging to determine the extent of lymph node involvement and plan treatment often requires a combination of modalities to avoid under-staging. The seventh edition of the staging system released by the International Union Against Cancer (IUCC) has stratified lymph node involvement according to the number of lymph nodes involved and redefined its groupings for location of metastatic lymph node involvement. This review discusses the prognostic and treatment implications of these modifications and explores micrometastatic lymph node involvement, capsular infiltration and lymph node ratio as possible additions to the staging system.

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“…Many previous studies [1][2][3][4][5][6][7][8][9] have demonstrated that the development of postoperative complications increased the risk of disease recurrence in various types of malignancies. Among surgical morbidities, infectious complications are the most frequent and directly related to surgery.…”

Section: Introductionmentioning

confidence: 99%

Impact of infectious complications on gastric cancer recurrence

et al. 2014

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Background Postoperative infectious complications increase disease recurrence in colorectal cancer patients. We herein investigated the impact of infectious complications on gastric cancer recurrence after curative surgery. Methods In total, 502 patients who underwent R0 resection for gastric cancer were reviewed. Patients were classified into those with infectious complications (IC group) and those without infectious complications (NO group). The risk factors for recurrence-free survival (RFS) were identified. Results Infectious complications, which occurred in 52 patients (10.4 %), included pneumonia, ileus with a systemic inflammatory reaction, anastomotic leakage, and intraperitoneal abscess. The overall 5-year RFS rate was 83 % in the NO group and 58 % in the IC group (p = 0.000). Multivariate analysis demonstrated that age, ASA score, stage, and infectious complications were significant predictors of RFS. Conclusions Infectious complications were a risk factor for gastric cancer recurrence. To avoid causing infectious complications, the surgical procedure, surgical strategy, and perioperative care should be carefully planned.

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Postoperative Complications After Transthoracic Esophagectomy for Cancer of the Esophagus and Gastroesophageal Junction Are Correlated With Early Cancer Recurrence

Cited by 244 publications

References 15 publications

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Impact of infectious complications on gastric cancer recurrence

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