2021
DOI: 10.1016/s2213-2600(21)00089-8
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Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial

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Cited by 39 publications
(12 citation statements)
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“…Recent studies have failed to find benefit with routine postoperative CPAP or noninvasive ventilation to prevent pneumonia and respiratory failure. 34 , 35 Infective complications were the most common, affecting one in 20 patients, and were associated with a one in 10 rate of death after 1 yr. However, growing evidence suggests only marginal benefit from liberal antimicrobial prophylaxis to prevent postoperative infection.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies have failed to find benefit with routine postoperative CPAP or noninvasive ventilation to prevent pneumonia and respiratory failure. 34 , 35 Infective complications were the most common, affecting one in 20 patients, and were associated with a one in 10 rate of death after 1 yr. However, growing evidence suggests only marginal benefit from liberal antimicrobial prophylaxis to prevent postoperative infection.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have demonstrated the benefits of prophylactic and therapeutic CPAP compared with respiratory physiotherapy and oxygen therapy following abdominal surgery (e.g., shorter hospital stays, fewer complications, and reduced morbidity) [ 4 6 ]. However, a recent report contradicted these findings and presented no difference in postoperative morbidity between CPAP or standard postoperative care [ 16 ]. However, this report included a broader definition of major surgery than that of the current study and a shorter treatment length (at least 4 h) than that presented by Ferreyra et al [ 4 ].…”
Section: Discussionmentioning
confidence: 99%
“…Literature has shown a host of clinical trials and attempts to reduce the rates of PPC [11][12][13]. Besides sufficient pain management, respiratory physiotherapy plays a major role in the routine recovery of surgical patients.…”
Section: Introductionmentioning
confidence: 99%