Postoperative corneal deposits the following polypharmacy

Babitha, Valiyaveettil; Prasannakumary, Chellappan; Fathima, Zuhara; Raju, Kuzhippally Vallon

doi:10.4103/2320-3897.190789

Cited by 5 publications

(11 citation statements)

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“…There is only one case report in literature that described corneal deposits following polypharmacy, one of which was topical moxifloxacin 7 . In the previous report, a post cataract surgery 68-year-old female was on topical moxifloxacin-dexamethasone phosphate combination hourly, and potassium iodide, calcium chloride, and sodium chloride in combination as eye drops four times daily from the first postoperative day due to retained cortical matter.…”

Section: Discussionmentioning

confidence: 99%

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Corneal deposits following topical moxifloxacin use

Alshamrani

Alharbi

2019

Saudi Journal of Ophthalmology

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Corneal deposits have been reported with numerous topical medications including fluoroquinolones. However, they have not been documented as a side effect of topical moxifloxacin. In this report, we describe the first case of corneal deposits following the use of preservative-free topical moxifloxacin 0.5% eye drops in a 26-year-old male with keratoconus who underwent a unilateral corneal cross-linking. Increased frequency and prolonged instillation of moxifloxacin eye drops led to corneal precipitation in this patient. Complete resolution of corneal deposits occurred four months after drug discontinuation without sequelae.

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Section: Discussionmentioning

confidence: 99%

“…Timolol maleate eye drops were also added. Corneal deposits were noted 3 weeks after beginning these medications 7 …”

Section: Discussionmentioning

confidence: 99%

Corneal deposits following topical moxifloxacin use

Alshamrani

Alharbi

2019

Saudi Journal of Ophthalmology

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“…Topical fluroquinolones are widely used in ophthalmology because of their broad spectrum of action and are readily available and cost effective. Corneal deposition of these drugs has been reported following treatment of bacterial keratitis,2 corneal transplant,10 cataract surgery,1,8 and LASEK 3. Ciprofloxacin is frequently associated with drug deposition in the cornea, however, in recent times, newer drugs like ofloxacin, gatifloxacin, moxifloxacin, and tosufloxacin have been found to cause similar depositions.…”

Section: Discussionmentioning

confidence: 99%

“…Deposition in the cornea is facilitated in the presence of an epithelial defect or severe ocular surface disorder and also in polypharmacy, probably due to the change in ocular pH. However, there are cases where drug depositions are seen despite intact corneal epithelium, and especially when associated with frequent dosing or polypharmacy 1,8. Ofloxacin is soluble at a pH of 6.4 and rarely precipitates, but there are reports in the literature where ofloxacin depositions have been documented 4,11,12…”

Section: Discussionmentioning

confidence: 99%

“…Fluoroquinolones are fluorinated derivatives of nalidixic acid and are broad-spectrum antimicrobial agents. Corneal deposits have been reported with topical administration of various fluoroquinolones including, ciprofloxacin,1–3 ofloxacin,4 gatifloxacin,5 sparfloxacin,6 moxifloxacin,7,8 and tosufloxacin 9,10. Herein, three cases of drug deposition in cornea post-penetrating keratoplasty (PK) have been reported.…”

Section: Introductionmentioning

confidence: 99%

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<p>Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series</p>

Sitaula

Singh

2019

IMCRJ

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Purpose: To report three cases of fluroquinolone deposition in the cornea after topical administration post-penetrating keratoplasty. Case reports: Herein we report three patients ranging in age from 42–65 years who underwent keratoplasty with cataract extraction, with intraocular lens implantation in the first two cases and left aphakic due to a posterior capsular tear in the third case. The first two patients received ciprofloxacin-dexamethasone combination drops, and developed drug deposition, which was observed at the first follow-up after 7 and 10 days respectively. The third patient received prednisolone acetate and ofloxacin eyedrops postoperatively, and developed drug deposits in the cornea after 20 days. In all of the three patients, the fluroquinolone group of drugs was discontinued and the cornea cleared gradually over the next 3–4 weeks. Although the cornea cleared, the first two grafts failed due to recurrent viral infection in one case, and graft rejection in the other case. Conclusion: Deposition of many different fluroquinolones in the cornea has been reported after a variety of surgeries, including penetrating keratoplasty. Drug deposition post-penetrating keratoplasty may seem innocuous due to self-resolution on cessation of the drugs, but it may have deleterious effects on graft survival. Hence, fluroquinolones, especially ciprofloxacin, should be cautiously used in patients undergoing penetrating keratoplasty if frequent dosing is prescribed or if used concurrently with other topical medications containing preservatives.

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Iatrogenic corneal diseases or conditions

Gomes

Filho

2021

Experimental Eye Research

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Postoperative corneal deposits the following polypharmacy

Cited by 5 publications

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Corneal deposits following topical moxifloxacin use

Corneal deposits following topical moxifloxacin use

<p>Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series</p>

Iatrogenic corneal diseases or conditions

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