Postoperative deep vein thrombosis caused by intravenous fluids during surgery

Abstract

Using a new method of measuring whole blood clotting time, we have confirmed the findings of others, that blood clots faster when diluted with saline. A prospective trial was designed to test the hypothesis that intravenous saline peroperatively causes hypercoagulation and increases the risk of venous thrombosis. Sixty patients admitted for routine laparotomy were randomly allocated to either a group receiving intravenous fluids during or after operation (Wet), or a group receiving no intravenous fluids (Dry). The Wet patients became significantly more haemodilute and hypercoagulable than the Dry (P < 0.001), and these changes correlated. A postoperative deep vein thrombosis occurred in 30 per cent of the Wet patients, but in only 7 per cent of the Dry (P < 0.05). The need for intravenous fluids during uncomplicated surgery is probably unproved, and their greater use may have contributed to the increasing prevalence of venous thromboembolism.

The Effect of Crystalloid vs. Crystalloid plus Colloid Infusion on the Coagulation System in Patients Undergoing Cancer Breast Surgery

“…Another study recorded contradictory results that the effects of the different HES solution on hemostasis were marked and obvious [28]. The concordance between our results and Haisch et al and discrepancy with Baldassarre et al recorded results can be explained that the used HES preparation and its amount by our and Haisch was the modified HES 130/0.4 with low MW and high degree of SD in moderate dose (500 ml) has mild negative effect on coagulation system [29]. Janverin and Colleges have previously shown an increase in coagulation and incidence of deep venous thrombosis in patients receiving crystalloid fluid during surgery [30].…”

The effect of potato starch derived and corn starch derived hydroxyethyl starch on in vitro blood coagulation

“…Moderate haemodilution with crystalloids may enhance blood coagulation in vitro [6,7] and in vivo [23][24][25]. In the present study, accelerated coagulation was observed at 30% haemodilution with 0.9% saline (Fig.…”

The effect of crystalloid infusion on body water content and intra-abdominal pressure in patients undergoing orthopedic surgery under spinal anesthesia

“…Crystalloid-related hypercoagulation increased the frequency of deep venous thrombosis in patients receiving normal saline solutions during major abdominal surgery compared with those who did not receive intravenous fluids. 23 Hip replacement and knee arthroplasty are moderately complex surgical procedures. Additionally, all of our patients routinely received low molecular heparin during the early postoperative period, and we did not note any clinical thromboembolic complications.…”