Postoperative Endophthalmitis Caused by &lt;b&gt;&lt;i&gt;Cutibacterium&lt;/i&gt;&lt;/b&gt; (Formerly &lt;b&gt;&lt;i&gt;Propionibacterium&lt;/i&gt;&lt;/b&gt;) Acnes: Case Series and Review

Fowler, Benjamin J.; Miller, Darlene; Yan, Xiao‐Xin; Yannuzzi, Nicolas A.; Flynn, Harry W.

doi:10.1159/000510208

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…More recently, the role of molecular testing by polymerase chain reaction or "PCR", is essential, and allows a microbiological diagnosis in 71% of cases of postoperative acute and delayed-onset endophthalmitis as demonstrated by Chiquet (37)(38)(39). However, diagnosis based on clinical ndings should be performed, without waiting for the microbiological results the to treat (22,29). E.faecalis was the only identi ed microorganism in our study.…”

Section: Discussionmentioning

confidence: 80%

Chronic Pseudophakic Endophthalmitis After Uneventful Phakoemulsification: A Case Series and Review of Litterature

Mili¹,

Braham

Kaouel³

et al. 2021

Preprint

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Purpose: To report a retrospective case series of patients with chronic post operative endophthalmitis (CPE) after uneventful phacoemulsification (PKE) with intraocular lens (IOL) implantation. Methods: this study was conducted between January 2011 and June 2020, including patients with delayed-onset endopthalmitis occurring at least 2 weeks after uneventful PKE+IOL. Diagnosis was based on typical clinical features associated or not to proven sample culture. Treatment was based on step-by-step management, depending on results of microbiology and response of treatment. It consisted in first line medical treatment with a two-approach intraocular and systemic antiobiotics, followed, if necessary, by a second line conservative-IOL surgical treatment with pars plana vitrectomy (PPV), and a third line non-conservative-IOL surgical treatment with re-PPV associated to IOL explantation. Results: Seven patients were included with a mean age of 62,5 years. Mean duration interval between cataract surgery and diagnosis of CPE was 31,3 weeks. All patients presented a decrease of visual acuity with white intracapsular plaques. Only one patient had positive IOL culture. Medical treatment was sufficient in three cases. In the four other cases, PPV with IOL explantation and total capsular bag removal was conducted. Mean final BCVA was 20/160 with a gain of 4 lines and was ≥ 20/40 in 4 cases. Conclusion: The diagnosis of CPE is still challenging especially for difficulties in isolating microorganisms. It should always be considered in cases of recurrent ocular inflammation resistant to conventional treatment in operated eyes. Non-conservative IOL surgical treatment may be directly necessary in severe cases.

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Section: Discussionmentioning

confidence: 80%

Chronic Pseudophakic Endophthalmitis After Uneventful Phakoemulsification: A Case Series and Review of Litterature

Mili¹,

Braham

Kaouel³

et al. 2021

Preprint

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“…Cutibacterium acnes (previously known as Propionibacterium acnes ) is known to cause an indolent late-onset postoperative endophthalmitis[ 21 ] and has been cultured from CBS fluid in eyes without other evidence of inflammation. [ 22 , 23 ] While C. acnes endophthalmitis has been reported following Nd: YAG laser posterior capsulotomy, these studies included eyes with PCO and without CBS.…”

Section: Discussionmentioning

confidence: 99%

Femtosecond laser-assisted posterior capsulotomy for the treatment of capsular block syndrome

Lim,

Patil,

Mehta

2023

Taiwan Journal of Ophthalmology

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We present a novel use of femtosecond laser to treat capsular block syndrome (CBS) in a patient with dense opaque capsular block, who presented 16 years postcataract surgery. The extensive posterior capsular distension and densely opaque, milky fluid trapped behind the intraocular lens (IOL) prevented the use of neodymium-doped yttrium aluminum garnet (Nd: YAG) laser posterior capsulotomy as primary treatment. Intra-operative optical coherence tomography enabled visualization of the posterior capsule and iris hooks were used to increase the pupillary diameter to enable femtosecond laser-assisted posterior capsulotomy to be performed in a minimally invasive technique. CBS was relieved successfully and Nd: YAG laser performed subsequently to remove residual posterior capsule opacification safely and with good visual outcomes. This method avoids risks associated with posterior vitrectomies and compromised IOL stability from inadvertent capsular bag damage, and adds to the expanding uses of femtosecond laser technology.

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“…Stenotrophomonas maltophilia and Corynebacterium macginleyi were detected in multiple cases of bacterial keratitis ( Cho and Lee, 2021 ; Sagerfors et al., 2021 ). Bacillus cereus , Enterococcus faecalis , Staphylococcus haemolyticus and cutibacterium acnes are considered as opportunistic pathogens of endophthalmitis ( Panda and Singh, 2018 ; Ehling-Schulz et al., 2019 ; Chen et al., 2021 ; Fowler et al., 2021 ). In the culture results of the control group, only two opportunistic pathogens were found, among which Acinetobacter lwoffii could induce endophthalmitis after cataract surgery ( Roy et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“…In the culture results of the control group, only two opportunistic pathogens were found, among which Acinetobacter lwoffii could induce endophthalmitis after cataract surgery ( Roy et al., 2015 ). The other, cutibacterium acnes , can cause postoperative endophthalmitis ( Fowler et al., 2021 ) and keratitis ( Ovodenko et al., 2009 ), but its detection rate on the ocular surface of TAO patients is significantly higher. In previous studies of TAO-exposed keratitis, successful bacterial culture include Pseudomonas sp., Acinetobacter sp., Corynebacterium sp., Escherichia coli , Streptoccocus pneumoniae , Staphylococcus aureus and Staphylococcus epidermidis , some of which were consistent with the results of sequencing and culture in this study ( Naik et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the ocular surface microbiota between thyroid-associated ophthalmopathy patients and healthy subjects

Dong

et al. 2022

Front. Cell. Infect. Microbiol.

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PurposeThyroid-associated ophthalmopathy (TAO) is a chronic autoimmune disease. In this study, high-throughput sequencing was used to investigate the diversity and composition of the ocular microbiota in patients with TAO.MethodsPatients with TAO did not receive treatment for the disease and did not have exposed keratitis. Patients with TAO (TAO group) and healthy individuals (control group) were compared. All samples were swabbed at the conjunctival vault of the lower eyelid. The V3 to V4 region of the 16S rDNA was amplified using polymerase chain reaction and sequenced on the Illumina HiSeq 2500 Sequencing Platform. Statistical analysis was performed to analyze the differences between the groups and the correlation between ocular surface microbiota and the disease. The ocular surface microbiota of patients and healthy individuals were cultured.ResultsThe ocular surface microbiota structure of TAO patients changed significantly. The average relative abundance of Bacillus and Brevundimonas increased significantly in the TAO group. Corynebacterium had a significantly decreased relative abundance (P<0.05). Paracoccus, Haemophilus, Lactobacillus, and Bifidobacterium were positively correlated with the severity of clinical manifestations or disease activity (P<0.05). Bacillus cereus and other opportunistic pathogens were obtained by culture from TAO patients.ConclusionsThis study found that the composition of ocular microbiota in patients with TAO was significantly different from that in healthy individuals. The ocular surface opportunistic pathogens, such as Bacillus, Brevundimonas, Paracoccus, and Haemophilus in TAO patients, increase the potential risk of ocular surface infection. The findings of this study provide a new avenue of research into the mechanism of ocular surface in TAO patients.

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Postoperative Endophthalmitis Caused by <b><i>Cutibacterium</i></b> (Formerly <b><i>Propionibacterium</i></b>) Acnes: Case Series and Review

Cited by 12 publications

References 31 publications

Chronic Pseudophakic Endophthalmitis After Uneventful Phakoemulsification: A Case Series and Review of Litterature

Chronic Pseudophakic Endophthalmitis After Uneventful Phakoemulsification: A Case Series and Review of Litterature

Femtosecond laser-assisted posterior capsulotomy for the treatment of capsular block syndrome

Comparison of the ocular surface microbiota between thyroid-associated ophthalmopathy patients and healthy subjects

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