2024
DOI: 10.22603/ssrr.2023-0106
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Postoperative Epidural Fibrosis: Challenges and Opportunities - A Review

Guido Lewik,
Gerrit Lewik,
Lena S. Müller
et al.

Abstract: Postoperative epidural fibrosis (EF) is still a major limitation to the success of spine surgery. Fibrotic adhesions in the epidural space, initiated via local trauma and inflammation, can induce difficult-to-treat pain and constitute the main cause of failed back surgery syndrome, which not uncommonly requires operative revision. Manifold agents and methods have been tested for EF relief in order to mitigate this longstanding health burden and its socioeconomic consequences. Although several promis… Show more

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