Purpose The purpose of this study was to compare the precision of bony resections during total knee arthroplasty (TKA) performed using diferent computer-assisted technologies. Methods Patients who underwent a primary TKA using an imageless accelerometer-based handheld navigation system (KneeAlign2®, OrthAlign Inc.) or computed tomography-based large-console surgical robot (Mako®, Stryker Corp.) from 2017 to 2020 were retrospectively reviewed. Templated alignment targets and demographic data were collected. Coronal plane alignment of the femoral and tibial components and tibial slope were measured on postoperative radiographs. Patients with excessive lexion or rotation preventing accurate measurement were excluded. Results A total of 240 patients who underwent TKA using either a handheld (n = 120) or robotic (n = 120) system were included. There were no statistically signiicant diferences in age, sex, and BMI between groups. A small but statistically signiicant diference in the precision of the distal femoral resection was observed between the handheld and robotic cohorts (1.5° vs. 1.1° diference between templated and measured alignments, p = 0.024), though this is likely clinically insigniicant. There were no signiicant diferences in the precision of the tibial resection between the handheld and robotic groups (coronal plane 0.9° vs. 1.0°, n.s.; sagittal plane 1.2° vs. 1.1°, n.s.). There were no signiicant diferences in the rate of overall precision between cohorts (n.s.). Conclusions A high degree of component alignment precision was observed for both imageless handheld navigation and CT-based robotic cohorts. Surgeons considering options for computer-assisted TKA should take other important factors, including surgical principles, templating software, ligament balancing, intraoperative adjustability, equipment logistics, and cost, into account. Level of evidence III.