“…In cases when the patient is hemodynamically stable and presents mild symptoms, conservative therapy is the treatment of choice, while open surgery should be reserved in life-threatening conditions or in case of failure, considering current therapy (4,5). Initial management comprises the following: gastrointestinal decompression by means of a probe, which allows fluid parenteral nutrition, distally to the fistula, external active drainage, water-electrolyte supplementation, and antibiotics therapy (2,6,7,9). The most significant factor considering conservative treatment consists in the combination of total parenteral nutrition, somatostatin or its analogue-octreotide, and PPIs.…”