Postoperative gastrointestinal physiology following operations on the stomach

Degen, Lukas; Beglinger, Christoph

doi:10.1159/000055887

Cited by 6 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another major consideration is the altered absorption of DOACs due to anatomical changes in patients who have undergone the surgical resection of a GI tumor. Anatomical alterations can cause changes in GI transit time, acidity, and surface area, affecting the bioavailability of DOACs 7071. Rivaroxaban, edoxaban, and dabigatran show pH-dependent solubility and require gastric acidity for their absorption.…”

Section: Special Considerations In Patients With Catmentioning

confidence: 99%

Current Management of Cancer-associated Venous Thromboembolism: Focus on Direct Oral Anticoagulants

2019

View full text Add to dashboard Cite

Cancer-associated venous thromboembolism (CAT) is a common complication associated with high morbidity and mortality. In accordance with major clinical trials comparing low-molecular-weight heparin (LMWH) with a vitamin K antagonist (VKA), LMWH is currently the standard treatment for CAT, owing to its efficacy for thrombosis recurrence and improved safety profile compared to VKA. Over the past few years, direct oral anticoagulants (DOACs) have emerged as potential alternative therapies to LMWH due to their convenient route of administration and predictable pharmacokinetics, but evidence for their use in CAT is inconclusive, as only a small fraction of the study populations in these trials had CAT. Recently, two large head-to-head trials comparing DOACs to LMWH in CAT patients reported comparable efficacies of DOACs with increased bleeding risk. Occasionally, CAT treatment can be challenging due to the heterogeneity of underlying malignancies and comorbidities. Renal insufficiency and gastrointestinal defects are the main obstacles in anticoagulant selection. Careful choice of treatment candidates and proper anticoagulant strategies are critical for the treatment of CAT; hence, more studies are required to address these challenges.

show abstract

Section: Special Considerations In Patients With Catmentioning

confidence: 99%

Current Management of Cancer-associated Venous Thromboembolism: Focus on Direct Oral Anticoagulants

2019

View full text Add to dashboard Cite

show abstract

“…The cutting of anatomical structures of the gastroduodenum are must during surgical interventions, with disturbance of many fine, sophisticated feedback systems which lead to many changes comparing to preoperative state [7][8][9][10]. Due to achievements of modern pharmacy many of gastric diseases virtually vanished, leaving young surgeons without experience in the field of gastric surgery.…”

Section: Introductionmentioning

confidence: 99%

Role of computer analysis in prediction of surgical outcome after Billroth II gastric resection

Cvetković

Milašinović²,

Filipović

et al. 2015

2015 IEEE 15th International Conference on Bioinformatics and Bioengineering (BIBE)

View full text Add to dashboard Cite

This paper presents computer analysis of how geometry of reconstructed gastrointestinal tract can influence outcome of Billroth II gastric resection. We performed threedimensional computer simulation in order to predict duodenal stump blowout. For creation of initial three dimensional FE models of preoperative gastroduodenal region we used data from Multi Slice Computer Tomography (MSCT). Using the initial model we performed virtual gastric surgery. All post operational models were examined separately in order to find correlation between post operational geometry and pressure in duodenal stump. Data acquired by methodology presented in this study can be valuable to surgeons for prediction of suture dehiscence after gastric surgery.

show abstract

“…These are unavoidable during surgical interventions, with disturbance of many fine, highly sophisticated feedback systems. These undesirable conditions lead to negative feedback mechanisms [15,16] that cause changes in physiological processes with respect to the preoperative state [17,18] . To date, it seems that insufficient attention has been paid to how the geometry and flow conditions affect the gastroduodenal system after distal gastric resection.…”

Section: Introductionmentioning

confidence: 99%

Computer simulation of flow and mixing at the duodenal stump after gastric resection

Filipović¹,

Cvetković²,

Isailović³

et al. 2009

WJG

View full text Add to dashboard Cite

AIM:To investigate the flow and mixing at the duodenal stump after gastric resection, a computer simulation was implemented. METHODS:Using the finite element method, two different Billroth Ⅱ procedure cases (A and B) were modeled. Case A was defined with a shorter and almost straight duodenal section, while case B has a much longer and curved duodenal section. Velocity, pressure and food concentration distribution were determined and the numerical results were compared with experimental observations. RESULTS:The pressure distribution obtained by numerical simulation was in the range of the recorded experimental results. Case A had a more favorable pressure distribution in comparison with case B. However, case B had better performance in terms of food transport because of more continual food distribution, as well as better emptying of the duodenal section. CONCLUSION:This study offers insight into the transport process within the duodenal stump section after surgical intervention, which can be useful for future patient-specific predictions of a surgical outcome.

show abstract

Postoperative gastrointestinal physiology following operations on the stomach

Cited by 6 publications

References 20 publications

Current Management of Cancer-associated Venous Thromboembolism: Focus on Direct Oral Anticoagulants

Current Management of Cancer-associated Venous Thromboembolism: Focus on Direct Oral Anticoagulants

Role of computer analysis in prediction of surgical outcome after Billroth II gastric resection

Computer simulation of flow and mixing at the duodenal stump after gastric resection

Contact Info

Product

Resources

About