Postoperative hormone replacement therapy for epithelial ovarian cancer patients: A systematic review and meta-analysis

Dong, Lixue; Ding, Chengyuan; Qiu, Lihua

doi:10.1016/j.ygyno.2015.07.109

Cited by 66 publications

(25 citation statements)

References 32 publications

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“…A recent meta-analysis reported that women with ovarian cancer who received menopausal hormone therapy after surgery had a significantly longer survival than those who did not (HR = 0.69, 95% CI = 0.61-0.79), but the lack of an association in the two randomized trials included in the analysis (HR = 1.03, 95% CI = 0.58-1.83) suggested the association may be attributable to confounding [45]. Interestingly, a more recent randomized trial not included in the metaanalysis showed a significantly better survival for women assigned to adjuvant menopausal hormone therapy compared to those who were not (HR = 0.63, 95% CI: 0.44-0.90) [46].…”

Section: Menopausal Status Age At Menopause and Menopausal Hormone mentioning

confidence: 99%

Prognostic implications of reproductive and lifestyle factors in ovarian cancer

Poole

Konstantinopoulos

Terry

2016

Gynecologic Oncology

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Section: Menopausal Status Age At Menopause and Menopausal Hormone mentioning

confidence: 99%

Prognostic implications of reproductive and lifestyle factors in ovarian cancer

Poole

Konstantinopoulos

Terry

2016

Gynecologic Oncology

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“…10 HRT has proven to be highly effective for treating menopausal symptoms caused by radical surgery. 11 Women with gynecologic cancer, including ovarian cancer, are considered candidates for HRT. 12 However, views on HRT and clinical practice have varied over the last several decades.…”

Section: Discussionmentioning

confidence: 99%

I Ching Balance Acupuncture Treatment of Migraines, Insomnia, and Depression in a Post-Ovariectomy Patient Receiving Hormone Replacement Therapy

Kotlyar

2018

Medical Acupuncture

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Surgical menopause is associated with symptoms that can affect a woman's quality of life (QoL) significantly. These symptoms include migraines, insomnia, and depression. A 45-year-old Caucasian female presented at an acupuncture clinic. Fourteen years prior, she had been diagnosed with ovarian carcinoma, underwent ovariectomy, and was prescribed hormone replacement therapy. Deteriorating QoL caused her to seek acupuncture for migraines, insomnia, and depression. The outcomes sought for treatment of this case included intensity, duration, and frequency of migraines, insomnia, and depression, as well as her QoL. The outcome measures were estimated monthly throughout her treatment. Each was rated on a numeric scale of 0-10 (0 = "the lowest possible" and 10 = "the worst imaginable"). At baseline, the patient rated the intensity, duration, and frequency of each complaint as 10. She was treated with 60-minute, I Ching Balance Acupuncture (ICBA) sessions once per week for 7 months. This acupuncture treatment did not cause any adverse events, pain, or discomfort. Her migraines, insomnia, and depression decreased to a great extent. In addition, this patient reported considerable improvement in her QoL. The improvement in her QoL was inversely related to the intensity, duration, and frequency of her complaints throughout her acupuncture treatment. This patient reported a considerable improvement in all the outcome measures. She completed the treatment after experiencing great improvement in her QoL. Additional, larger-scale studies are warranted to investigate the effects of ICBA.

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“…With regard to duration, there is insufficient data on the effect of long or short term use of HRT on the onset or progression of ovarian cancer. A recent metaanalysis conducted by Li et al on 1448 patients who investigated the effect of postoperative HRT on the clinical outcome of patients treated for EOC revealed that post-operative HRT did not have an impact on surveillance and recurrence (HR = 0.68, 95% CI: 0.54-0.86) [23].…”

Section: Ovarian Cancermentioning

confidence: 99%

The Role of Hormone Replacement Therapy in the Treatment of Menopausal Symptoms in Patients Diagnosed with Gynecologic Cancer

Çilgin¹

2020

Hormone Therapy and Replacement in Cancer and Aging-Related Diseases

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The incidence of most cancers increases with age, especially from middle age onward, so today cancer can be considered an age-related disease. One of the keys to healthy and successful aging is reducing the advent of serious disabilities caused by diseases related to aging. One of the cornerstones of anti-aging is hormone replacement therapy to treat age-related diseases caused by sex hormone deficiency in women. However, there are many studies that question the relationship between hormone replacement therapies with cancer recurrence. Hormone replacement therapy (HRT) has the potential to affect both quality of life and survival in menopausal women. Although data in the literature is controversial, many clinicians remain reluctant to write HRT for gynecologic cancer patients due to fear of relapse but HRT does not appear to be associated with an increased risk of relapse in ovarian and endometrial cancer survivors, especially when used for a short period of time.

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Postoperative hormone replacement therapy for epithelial ovarian cancer patients: A systematic review and meta-analysis

Cited by 66 publications

References 32 publications

Prognostic implications of reproductive and lifestyle factors in ovarian cancer

Prognostic implications of reproductive and lifestyle factors in ovarian cancer

I Ching Balance Acupuncture Treatment of Migraines, Insomnia, and Depression in a Post-Ovariectomy Patient Receiving Hormone Replacement Therapy

The Role of Hormone Replacement Therapy in the Treatment of Menopausal Symptoms in Patients Diagnosed with Gynecologic Cancer

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