Postoperative hunger after outpatient surgery in patients anesthetized with propofol vs sevoflurane: a randomized-controlled trial

Besnier, Emmanuel; Perdrix, A.; Gillibert, André; Selim, Jean; Froemer, Benoit; Ghemired, Antoine; Berby, Benoît; Rives, Nathalie; Bertrand, Denis; Clavier, Thomas; Compère, Vincent

doi:10.1007/s12630-020-01584-w

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…3E). The decrease in ghrelin observed in the sham group could be due to effects of inhaled anesthetics and endoscopic intervention, consistent with previously published findings ( 18 – 21 ).…”

Section: Resultssupporting

confidence: 92%

Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation

et al. 2023

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The gut-brain axis, which is mediated via enteric and central neurohormonal signaling, is known to regulate a broad set of physiological functions from feeding to emotional behavior. Various pharmaceuticals and surgical interventions, such as motility agents and bariatric surgery, are used to modulate this axis. Such approaches, however, are associated with off-target effects or post-procedure recovery time and expose patients to substantial risks. Electrical stimulation has also been used to attempt to modulate the gut-brain axis with greater spatial and temporal resolution. Electrical stimulation of the gastrointestinal (GI) tract, however, has generally required invasive intervention for electrode placement on serosal tissue. Stimulating mucosal tissue remains challenging because of the presence of gastric and intestinal fluid, which can influence the effectiveness of local luminal stimulation. Here, we report the development of a bioinspired ingestible fluid-wicking capsule for active stimulation and hormone modulation (FLASH) capable of rapidly wicking fluid and locally stimulating mucosal tissue, resulting in systemic modulation of an orexigenic GI hormone. Drawing inspiration from Moloch horridus, the “thorny devil” lizard with water-wicking skin, we developed a capsule surface capable of displacing fluid. We characterized the stimulation parameters for modulation of various GI hormones in a porcine model and applied these parameters to an ingestible capsule system. FLASH can be orally administered to modulate GI hormones and is safely excreted with no adverse effects in porcine models. We anticipate that this device could be used to treat metabolic, GI, and neuropsychiatric disorders noninvasively with minimal off-target effects.

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Section: Resultssupporting

confidence: 92%

Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation

et al. 2023

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“… 37 , 41 Previous study done in France has shown that, compared with sevoflurane, propofol did not accelerate the recovery of appetite after outpatient minor surgery. 42 Furthermore, propofol had no influence on other clinical or biological markers connected with food intake.…”

Section: Discussionmentioning

confidence: 96%

Incidence and Associated Factors of Postoperative Undesirable Anesthetic Outcomes Among Surgical Patients at Referral Hospitals in Amhara Region, Ethiopia: A Multi-Center Study

Admassie¹,

Admass²,

Melesse³

2023

PROM

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Background Patients undergoing surgery frequently experience unfavorable anesthetic outcomes. They may have an impact on body systems and result in more serious postoperative morbidities. This study was conducted to determine the incidence of postoperative undesirable anesthetic outcomes among surgical patients at referral hospitals in Amhara region, Ethiopia. Methods A total of 412 patients, who underwent surgical procedures between August 1 and October 30 of 2022, were included in this study. The Leiden Perioperative Care Patient Satisfaction Questionnaire’s (LPPSq) dimension “discomfort and needs” was used to collect data on the first postoperative day. Data entry and analysis were performed using SPSS version 20. To assess how risk factors affected the outcome variable, logistic regression analysis was utilized. In multivariable logistic regression analysis, a variable with a P-value of less than 0.05 was statistically considered as significant. Results The proportion of those who had “at least a little bit” of unfavorable outcomes was calculated to estimate their overall prevalence, and the prevalence of those who had “more than moderate” levels of unfavorable outcomes was determined to appreciate how severe these outcomes were. The percentages of postoperative pain, the most common undesired result, for “at least a little bit” and “more than moderate” were 87.7% and 32.3%, respectively. In this study, postoperative cold was the least prevalent (51.4%) undesirable anesthetic outcome. The remaining undesirable postoperative outcomes were reported less frequently. Conclusion and Recommendation Undesirable postoperative anesthetic outcomes were still common. The most frequent unfavorable result was postoperative pain. Adequate postoperative patient follow-up and quality service are paramount.

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“…We read with interest the report of the recent randomized-controlled trial conducted by Besnier et al 1 In this study, the authors compared the effects of propofol and sevoflurane on postoperative hunger in outpatients undergoing transvaginal oocyte retrieval and showed that propofol did not promote recovery of hunger. We would like to put forward some potential limitations in their study related to their statistical handling of the data.…”

Section: To the Editormentioning

confidence: 99%

Potential statistical issues in a study comparing postoperative hunger in patients anesthetized with propofol or sevoflurane

Zhao

Gao

2020

Can J Anesth/J Can Anesth

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Postoperative hunger after outpatient surgery in patients anesthetized with propofol vs sevoflurane: a randomized-controlled trial

Cited by 7 publications

References 32 publications

Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation

Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation

Incidence and Associated Factors of Postoperative Undesirable Anesthetic Outcomes Among Surgical Patients at Referral Hospitals in Amhara Region, Ethiopia: A Multi-Center Study

Potential statistical issues in a study comparing postoperative hunger in patients anesthetized with propofol or sevoflurane

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