Postoperative inflammatory response in colorectal cancer surgery: a meta-analysis

Kampman, S. L.; Smalbroek, B. P.; Dijksman, L. M.; Smits, A. B.

doi:10.1007/s00384-023-04525-3

Cited by 7 publications

(6 citation statements)

References 57 publications

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“…Current study suggests that HEIC in process of rectal cancer surgery is a promising strategy for preventing cancer metastasis and improving treatment outcomes. The inflammatory in cancer with the proliferation, differentiation and secretion of immune cells were observed within the intestinal region, and mucosal membranes of intestinal is a large immune organs [10,11]. How to use intraoperatively induced inflammatory responses to control tumor cells left over surgery is very important, HEIC has been successfully integrated into esophagectomy and has shown to effectively immune responses following surgery [12].…”

Section: Discussionmentioning

confidence: 99%

“…To improve the long term survival rate of surgical treatments and at the same time to prevent the local residual tumor and extrusion residual metastasis caused by surgery, there have been a lot of tools and surgical robots that have improved surgery to perfect and make it more successful [9]. The postoperative inflammatory response in colorectal cancer surgery was observed and it was discussed the proliferation, differentiation and secretion of immune cells, within the intestinal region following remodeling of the microenvironment, also intestinal tract is the largest digestive organ in the human body [10,11]. These studies call into question how we can use the surgery inflammatory response from the surgery to control tumor cell regeneration and tumor recovery, there is a good example for immune reaction induced by hapten enhanced intratumoral chemotherapy during esophagectomy for explore possible immunosurgery [12].…”

Section: Introductionmentioning

confidence: 99%

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Using Scrna-Seq to Define the Immune Response after Hapten Enhanced Intratumoral Chemotherapy on Cases of Rectal Cancer:Exploring Immune Surgery

2024

J Surg

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Objective: Surgery is an major methods for rectal cancer and is significantly improved thorough not only combine with modern medical equipment also combine with immune therapy. Awaking the immune cells can be effectively eliminated residual tumor cells following the surgical of tumor. Hapten Enhanced Intratumoral Chemotherapy (HEIC) has successful applied into cancer treatment. HEIC integrated into surgery is a new way to improve outcome of surgery while the immune response is elicited during of rectal surgery.Method: Single-Cell RNA Sequencing (scRNA-seq) was used to investigate changes of immune cells at the molecular and cellular identities in tumors before and after surgery with HEIC.Result: A total of 43,406 cells, 10 cell types, Epithelial Cells(EpithelialCells), Endothelial Cells(ECs), Fibroblasts, B Cells(BCells), Plasma Cells(PlasmaCells), TandNK Cells(TandNK), Neutrophils, Mast Cells(MastCells), Mononuclear Phagocytes(MPs), Platelets were induced by HEIC treatment 1 hour later. Proportion of plasma cells decreased, especially the proportion of T&NK cells increased after treatment, and the number of Tumor Infiltrating Lymphocytes (TILs) increased. Activate of immune response in tumor almost immediate impact the peripheral blood samples for whole body immune response with a large proportion up of T&NK cells. The gene set was enriched into tumor-related signaling pathways such as apoptosis, IL-7 and TNF. IL-7 is an important growth factor for T cell development and survival. Conclusion:Immune rectal cancer surgery can be performed by HEIC, it resulted in the tumor is cut out of body, then the immune response is set up and restore in the patient's own body for prevent the tumor metastasis after the removal of tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Using Scrna-Seq to Define the Immune Response after Hapten Enhanced Intratumoral Chemotherapy on Cases of Rectal Cancer:Exploring Immune Surgery

2024

J Surg

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Section: Discussionmentioning

confidence: 99%

“…Studies have reported that laparoscopic surgery for colorectal cancer, relative to open abdominal surgery, reduces the increase in serum IL-6 levels after surgery ( 27 , 28 ). This reduction may be due to less trauma to the abdominal wall caused by laparoscopic surgery than by conventional open surgery ( 9 , 11 , 27 , 28 ). Our study showed that mini-laparotomy surgery for colorectal cancer was significantly associated with decreased increment of IL-6 at 2 h after surgery [IL-6 (Δ2 h)].…”

Section: Discussionmentioning

confidence: 99%

Abdominal wound length influences the postoperative serum level of interleukin-6 and recovery of flatus passage among patients with colorectal cancer

Tsai,

Chen,

Lin

et al. 2024

Front. Surg.

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IntroductionA mini-laparotomy for colorectal cancer (CRC) has been reported to shorten postoperative ileus (POI) and hospital stay. Interleukin-6 (IL-6) plays a role in intestinal tissue inflammation, leading to POI. This study investigated the effects of abdominal wounds and IL-6 levels on POI in patients having CRC surgery.Materials and methodsForty-three patients with CRC underwent bowel resection. Serum samples were collected preoperatively and at 2, 24, and 48 h after surgery for cytokine quantification by ELISA. Clinical data, including time from surgery to first passage of flatus and postoperative hospital stay, demographic and pathological data, and routine blood tests, were compared statistically with abdominal wound length and the postoperative increments of cytokines (designated as Δ).ResultsThe length of the abdominal wound showed a significant correlation with clinical variables (length of operation time, time of first flatus passage, and length of postoperative hospital stay) and cytokine variables (IL-6(Δ2 h), IL-8(Δ2 h) and IL-10(Δ2 h). Linear regression analysis showed that the abdominal wound length significantly influenced the operation time, time of first flatus passage, and length of postoperative hospital stay (p < 0.001). The length of the abdominal wound showed a significant influence on the IL-6(Δ2 h) and IL-8(Δ2 h) (p < 0.001, respectively) but no influence on IL-10(Δ2 h). IL-6(Δ2 h), but not IL-8(Δ2 h), significantly influenced the time to first flatus passage and length of hospital stay (p = 0.007, p = 0.006, respectively). The mini-laparotomy approach (wound length <7 cm) led to significantly shortened operation time, time of first flatus passage, length of postoperative stay (p = 0.004, p = 0.003, p = 0.006, respectively) as well as reduced postoperative increment of IL-6(Δ2 h) (p = 0.015). The mini-laparotomy for anterior resection surgery significantly influenced operation time, time of first passage of flatus, length of postoperative stay, and IL-6(Δ2 h).ConclusionOur study is the first to report the complex interaction among the length of the abdominal wound, IL-6 serum level, recovery of the first passage of flatus, and postoperative hospital stay. These results suggest that smaller abdominal wounds and smaller postoperative IL-6 increments were associated with faster recovery of flatus passage and shorter hospital stays.

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“…Nonetheless, the rapid recovery associated with minimally invasive surgery can improve systemic inflammatory and nutritional status postoperatively. In a meta-analysis comparing laparoscopic and open colorectal surgeries, laparoscopic surgery demonstrated lower levels of CRP and IL-6 compared to open surgery [39]. Additionally, the implementation of ERAS protocol to minimize surgical stress response through minimally invasive surgery has shown an association with improved long-term cancer-specific survival in CRC patients [40].…”

Section: Discussionmentioning

confidence: 99%

Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer

Park,

Woo,

Hong

et al. 2023

Cancers

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Background: The Naples prognostic score (NPS) is a scoring system that reflects a patient’s systemic inflammatory and nutritional status. This study aimed to evaluate whether postoperative NPS is effective in assessing the prognosis of stage II–III colorectal cancer (CRC) patients compared with preoperative NPS. Methods: Between 2005 and 2012, a total of 164 patients diagnosed with stage II–III CRC, who underwent curative resection followed by adjuvant chemotherapy, were divided into two groups: Group 0–1 (NPS = 0–2) and Group 2 (NPS = 3 or 4). Preoperative NPS was calculated based on the results before surgeries, and postoperative NPS was assessed using the results obtained before adjuvant chemotherapy. Results: The overall survival of Group 0–1 was higher than that of Group 2 in both pre- and postoperative NPS assessments. According to the ROC curve analysis, the Area Under the Curve (AUC) ratio for postoperative NPS was 0.64, compared with 0.57 for preoperative NPS, 0.52 for the preoperative neutrophil–lymphocyte ratio (p = 0.032), and 0.51 for the preoperative platelet–lymphocyte ratio (p = 0.027). Conclusions: Postoperative NPS is effective in predicting the prognosis of stage II–III CRC patients who underwent curative resection followed by adjuvant chemotherapy. The use of NPS could be beneficial in evaluating the prognosis of CRC patients after surgeries.

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Postoperative inflammatory response in colorectal cancer surgery: a meta-analysis

Cited by 7 publications

References 57 publications

Using Scrna-Seq to Define the Immune Response after Hapten Enhanced Intratumoral Chemotherapy on Cases of Rectal Cancer:Exploring Immune Surgery

Using Scrna-Seq to Define the Immune Response after Hapten Enhanced Intratumoral Chemotherapy on Cases of Rectal Cancer:Exploring Immune Surgery

Abdominal wound length influences the postoperative serum level of interleukin-6 and recovery of flatus passage among patients with colorectal cancer

Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer

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