Postoperative intra-abdominal infection and colorectal cancer recurrence: A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association

Alonso, Sandra; Pascual, Marta; Salvans, Sílvia; Mayol, Xavier; Mojal, Sergi; Gil, María José; Grande, Luís; Pera, Miguél

doi:10.1016/j.ejso.2014.10.052

Cited by 79 publications

(57 citation statements)

References 35 publications

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“…Postoperative complications might also play a role in long‐term survival. Anastomotic leakage and infectious complications are related to disease recurrence in various cancer types. The association between textbook outcome and overall survival underlines the importance of an optimal perioperative care path for patients undergoing oesophagogastric cancer surgery.…”

Section: Discussionmentioning

confidence: 99%

Using textbook outcome as a measure of quality of care in oesophagogastric cancer surgery

Kaaij

Rooij

Coevorden

et al. 2018

British Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Using textbook outcome as a measure of quality of care in oesophagogastric cancer surgery

Kaaij

Rooij

Coevorden

et al. 2018

British Journal of Surgery

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“…Krarup et al [17] found that complications did not impact on the rate of local recurrence, but was associated with increased rates of distant recurrence. Alonso et al [18] also showed this association. Postoperative morbidity also impacts on outcomes after resection of hepatic colorectal metastases [19].…”

Section: Colorectal Cancermentioning

confidence: 75%

The Impact of Surgical Complications on Cancer Recurrence Rates: A Literature Review

et al. 2018

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Introduction: The inflammatory response to a post-operative infection can increase the risk of tumour recurrence in cancer through the release of pro-inflammatory mediators. The aim of this study was review the literature to assess the relationship between post-operative complications and cancer recurrence. Methods: We performed a literature review of the mechanism of such an association and looked at evidence in different cancer subtypes. Results: A relationship has been identified for many cancer subtypes, and multiple theories have been proposed for the mechanism of this association. Methods to reduce post-operative complications may impact positively on cancer recurrence rates. Conclusion: This review demonstrates that wound complications after surgery can have significant implications for cancer patients. Strategies are required to minimize the risk of post-operative wound complications in patients undergoing cancer resection.

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“…In vitro treatment of MDA-MB-231 cancer cells with peritoneal fluid from CRC patients experiencing anastomotic complications was shown to impact both tumor invasiveness and proliferation [97]. These oncological stimulatory effects were suggested to result from the proinflammatory response towards peritoneal infection, facilitating tumor recurrence through secretion of multiple tumor stimulatory factors including IL-6 and VEGF [98]. In mouse models, gut microbiota was found to play a significant role in modulating the immune response towards checkpoint inhibitor immunotherapy.…”

Section: Mainmentioning

confidence: 99%

Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity

Bakos¹,

Lawson²,

Rouleau³

et al. 2018

j. immunotherapy cancer

142

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BackgroundCancer surgery is necessary and life-saving. However, the majority of patients develop postoperative recurrence and metastasis, which are the main causes of cancer-related deaths. The postoperative stress response encompasses a broad set of physiological changes that have evolved to safeguard the host following major tissue trauma. These stress responses, however, intersect with cellular mediators and signaling pathways that contribute to cancer proliferation.MainPrevious descriptive and emerging mechanistic studies suggest that the surgery-induced prometastatic effect is linked to impairment of both innate and adaptive immunity. Existing studies that combine surgery and immunotherapies have revealed that this combination strategy is not straightforward and patients have experienced both therapeutic benefit and drawbacks. This review will specifically assess the immunological pathways that are disrupted by oncologic surgical stress and provide suggestions for rationally combining cancer surgery with immunotherapies to improve immune and treatment outcomes.Short conclusionGiven the prevalence of surgery as frontline therapy for solid cancers, the emerging data on postoperative immunosuppression and the rapid development of immunotherapy for oncologic treatment, we believe that future targeted studies of perioperative immunotherapy are warranted.

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Postoperative intra-abdominal infection and colorectal cancer recurrence: A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association

Cited by 79 publications

References 35 publications

Using textbook outcome as a measure of quality of care in oesophagogastric cancer surgery

Using textbook outcome as a measure of quality of care in oesophagogastric cancer surgery

The Impact of Surgical Complications on Cancer Recurrence Rates: A Literature Review

Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity

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