Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

Parsa, Tahereh

doi:10.26420/austinjanesthesiaandanalgesia.2018.1067

Austin J Anesthesia and Analgesia

2018

DOI: 10.26420/austinjanesthesiaandanalgesia.2018.1067

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Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

Tahereh Parsa¹

Abstract: Introduction: Compared with volatile anesthetics, less information is available about the hepatic and renal impact of intravenous anesthetics. The aim of the present study was to evaluate and compare the effect of midazolam and propofol on postoperative liver and renal functions.

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2022

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A Comparison of the Effect of Isoflurane and Propofol on Liver Enzymes

Oladimeji

Desalu

Adekola

et al. 2022

Journal of West African College of Surgeons

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Background: Isoflurane and propofol are routinely used for the maintenance of general anaesthesia. However, recently, they have been implicated in hepatotoxicity resulting in acute liver failure. Objective: We compared the effects of isoflurane and propofol on liver enzymes; aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (ALP) and total bilirubin (Tbil) following general anaesthesia. Materials and Methods: This randomized, controlled clinical trial involved 60 ASA I and II patients aged 18–64 years scheduled for elective surgery requiring general anaesthesia. Anaesthesia was induced with intravenous sodium thiopentone 5 mg/kg and atracurium 0.5 mg/kg, and maintained in group I with isoflurane (MAC, 0.8%-1.5%) and in group P with (propofol infusion, 100–200µg/kg/minute). Blood samples were taken pre-induction, immediate- and 24 hours post operatively. The serum levels of AST, ALT, ALP, Tbil were analyzed and compared in both groups. Risk factors for post operative hepatotoxicity were determined. Result: Propofol caused a significant reduction in ALP ( P = 0.005) but increase in Tbil ( P = 0.010) 24 hours postoperatively. Though isoflurane had consistently higher values of AST, ALP and Tbil than propofol, only the mean AST values at 24 hours post-operative was significantly higher ( P = 0.045). There was a significant increase in the 24 hours post-operative Tbil following massive blood loss; [odd ratio 23.91, 95%, CI (1.685–339.315)], P = 0.019. Conclusion: Both agents had a varied effect on liver enzymes. Isoflurane resulted in a significantly higher increase in 24 hours post-operative serum AST than propofol. Propofol caused a significant increase in 24 hours post-operative total bilirubin. Caution is therefore recommended in their use in patients with altered liver enzymes.

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A Comparison of the Effect of Isoflurane and Propofol on Liver Enzymes

Oladimeji

Desalu

Adekola

et al. 2022

Journal of West African College of Surgeons

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Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

Abstract: Introduction: Compared with volatile anesthetics, less information is available about the hepatic and renal impact of intravenous anesthetics. The aim of the present study was to evaluate and compare the effect of midazolam and propofol on postoperative liver and renal functions.

Cited by 1 publication

References 19 publications

A Comparison of the Effect of Isoflurane and Propofol on Liver Enzymes

A Comparison of the Effect of Isoflurane and Propofol on Liver Enzymes

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