Postoperative Long-Term Course of Peripheral Blood Immune Parameters and Immunomodulating Effects of Keyhole Limpet Hemocyanin in Patients with Nonmetastatic Renal Cell Carcinoma

Kleinknecht, S; Kh, Bichler; Wl, Strohmaier

doi:10.1159/000474864

Cited by 3 publications

(2 citation statements)

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“…(T-microglobulin, T N F and the immunoglobu lins did actually increase by up to 50% above prethera pcutic values under this schedule. The increases, how ever, were less pronounced than in patients with nonmetastatic renal cell carcinoma [29,30] who had received K LH . i.e.…”

Section: Discussionmentioning

confidence: 96%

Immune Modulating Effects of Low Doses of Cyclophosphamide and Keyhole Limpet Hemocyanine on Peripheral Blood Immune Parameters in Patients with Metastatic Renal Cell Carcinoma

Kleinknecht

Bichler²,

Strohmaier³

1992

Urol Int

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Assessing the peripheral blood immune status, we had found evidence of immunosuppression in metastatic renal cell carcinoma. Since immunosuppression might interfere with the outcome of immunotherapy, it was submitted to further investigation. Immunosuppression can be mediated by T suppressor cells, which for their part are inhibited by low-dose cyclophosphamide (Cy). We tested whether the immunomodulating effects of the biological response modifier keyhole limpet hemocyanine (KLH) on cellular and humoral immune parameters would be intensified by low-dose Cy. 10 patients were given 300 mg/m² Cy i.v. 3 days before application of 1 mg KLH i.m. up to 8 times in 4-weekly intervals. Immune parameters were assayed twice pretherapeutically, and prior to and 1 day and 1 week after each KLH injection. In contrast to the results obtained with KLH-monoapplication, lymphocyte subsets – with the exception of T4 cell counts and the T4/T8 ratio – remained stable during the first 4 months of observation. There were increases in immunoglobulines and in the immunoactivation markers tumor necrosis factor, neopterin and Β₂-microglobulin. The tendencies found here differed from those found in a previous study on patients who were given KLH alone, and were similar to those found in patients with nonmetastatic disease who received KLH alone. However, the increases of the activation markers during KLH + Cy application were at best half as much as in patients with nonmetastatic disease. In conclusion, immunosuppression was influenced, but not counterbalanced by low-dose Cy. Most probably other mediators of immunosuppression than T suppressor cells, for example prostaglan-din E₂, must be considered as well. Treatment of immunosuppression, however, seems to be a promising concept for improving the clinical results of immunotherapy.

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Section: Discussionmentioning

confidence: 96%

Immune Modulating Effects of Low Doses of Cyclophosphamide and Keyhole Limpet Hemocyanine on Peripheral Blood Immune Parameters in Patients with Metastatic Renal Cell Carcinoma

Kleinknecht

Bichler²,

Strohmaier³

1992

Urol Int

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“…Higher neopterin measurements not only provide an insight into the present state of cellmediated immune response but also allow monitoring and prognosis of disease progression [30]. Our results indicated that, patients with late stage cancer were still immunosuppressed, when compared to patients with non-metastatic disease, despite surgical removal of the tumor [31]. Furthermore, IDO inhibition may significantly enhance the antitumor activity of various chemotherapeutic and immunotherapeutic agents.…”

Section: Discussionmentioning

confidence: 74%

Serum neopterin concentrations and tryptophan degradation pattern in patients with late stage larynx carcinoma

et al. 2017

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AbstractAs the disease-free 5-year-survival of late stage laryngeal carcinoma patients is extremely low, indoleamine-2,3-dioxygenase-1 (IDO)-induced tryptophan degradation may represent an immune escape mechanism which plays an important role in cancer spreading in advanced stage laryngeal cancers. We examined whether the late stage laryngeal cancer enhances tumor immune evasion by the expression of systemic IDO activities and chronic cellular immune activation. Twenty-two of 42 male laryngeal cancer patients were classified as late stage cancer according to American Joint Committee on Cancer (AJCC) criteria. Their serum neopterin, tryptophan and kynurenine concentrations were compared with 30 cancer-free individuals. IDO activity was approved by correlation between serum neopterin and kynurenine/tryptophan. Late stage cancer patients preoperatively showed a significantly higher IDO activity compared to controls and early stage cancer cases. Six months after tumor removal, late stage cancer patients although having higher serum neopterin concentration compared to early stage patients or controls, they showed a significant decrease in IDO activity and tryptophan consumption. Increased systemic IDO activity may provoke the escape of tumor cells from the immune surveillance of the host. High IDO activity is due to the presence of tumor mass. Persistence of high serum neopterin levels despite tumor removal may indicate poor prognosis.

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Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status

Petit

Biard²

2013

ACAMC

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Marine ecosystems constitute a huge reservoir of biologically active secondary metabolites. Consequently during the last past few decades, several marine-derived molecules have been approved for anticancer treatment or are under clinical trials. This review reports the present state of the art of the sixteen molecules approved or currently on the clinical pipeline for anticancer chemotherapy. The molecules are classified according to their current status in the phase (approved / phase IV / phase III / phase II / phase I) and data are updated to April 2012.

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Postoperative Long-Term Course of Peripheral Blood Immune Parameters and Immunomodulating Effects of Keyhole Limpet Hemocyanin in Patients with Nonmetastatic Renal Cell Carcinoma

Cited by 3 publications

References 0 publications

Immune Modulating Effects of Low Doses of Cyclophosphamide and Keyhole Limpet Hemocyanine on Peripheral Blood Immune Parameters in Patients with Metastatic Renal Cell Carcinoma

Immune Modulating Effects of Low Doses of Cyclophosphamide and Keyhole Limpet Hemocyanine on Peripheral Blood Immune Parameters in Patients with Metastatic Renal Cell Carcinoma

Serum neopterin concentrations and tryptophan degradation pattern in patients with late stage larynx carcinoma

Marine Natural Products and Related Compounds as Anticancer Agents: an Overview of their Clinical Status

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