Postoperative nausea and vomiting following lower limb surgery :a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia

Abstract

Study Objective : the incidence of postoperative nausea and vomiting (PONV) following single-injection intraarticular anesthesia was compared to that following continuous epidural anesthesia. Design : Prospective, double-blind, randomized study. Setting : University-affiliated teaching hospital. Patients : Forty-eight patients finally participated in this study, and each group contained twenty-four patients. Interventions : Patients scheduled to undergo lower limb surgery under general anesthesia were randomly allocated into two groups, to receive either single-injection intraarticular or continuous epidural anesthesia for postoperative analgesia. Measurements : The incidence and severity of PONV, complete response rates (i.e., no vomiting or rescue antiemetic use), and pain scores were recorded 2, 24, and 48 h postoperatively. Main results : No significant differences between groups were observed in the incidence and severity of PONV, rescue antiemetic use, or complete response rate at any of the time points, but only the use of rescue analgesics was significantly less in continuous epidural anesthesia group during the 2-24h postoperative period (P=0.04). Conclusion : While the use of single-injection intraarticular anesthesia following lower limb surgery did not prevent PONV more than continuous epidural anesthesia in this study, the intraarticular technique still provides greater simplicity, safety, and cost-effectiveness.

Occurrence and Severity of Catheter-Related Bladder Discomfort of General Anesthesia Plus Epidural Anesthesia vs. General Anesthesia in Abdominal Operation With Urinary Catheterization: A Randomized, Controlled Study

“…(2) GA + EA group: the epidural catheter was inserted in T10-T11, T11-T12, or T12-L1 of the thoracolumbar junction, as appropriate (15)(16)(17). When the epidural intubation was completed, lidocaine (Shanghai Zhaohui Pharmaceutical Co., Ltd., China) (1%, 3 mL) was used as a test dose, and the anesthesia induction was administered with sufentanil 0.2-0.5 g/kg, propofol 1.5-2.5 mg/kg, rocuronium 0.6 mg/kg, and continuously-pumped remifentanil at 2-4 ng/mL.…”

Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial

“…Postoperative nausea and vomiting (PONV) is a common adverse effect that often occurs after surgery under general anesthesia. PONV occurs in approximately 30% of all postsurgical patients who receive general anesthesia, and its incidence rate can be up to 80% in high-risk patients (patients who are female, are nonsmokers, have a history of PONV, and receive postoperative opioids) [ 1 , 2 , 3 , 4 ]. Furthermore, owing to its surgical site characteristics, the incidence rate of PONV in patients who undergo tympanoplasty with mastoidectomy, which is a middle ear surgery, is 50–80% [ 5 , 6 ].…”

“…1 p values were derived from the independent t-test. 2 p values were derived from Mann-Whitney's U test 3. p values were derived from the chi-squared test 4.…”