Necrotizing soft tissue infections (NSTIs) are serious and potentially fatal rapidly progressive and aggressive infections of subcutaneous tissue, fascia, and sometimes muscles (manifesting as necrotizing pyomyositis). They are characterized by rapid spread and are associated with significant morbidity and mortality (1,2). Published studies report various incidence data for NSTIs. Chen LL reported an incidence of NSTIs of 0.3 to 15 cases per 100,000 population (3), and several other studies reported an annual incidence rate ranging from 0.72 to 9.2 per 100,000 person-years (4). NSTIs occur less frequently in children than in adults, with an incidence of 0.08 to 0.13 per 100,000 per year (5). Based on previous research and data available in the literature, they occur more often in men, accounting for up to 2/3 of all cases (6).Regarding treatment outcomes, an important predictive factor is the patient's age, even though there is no age predilection for NSTIs. Those over 50 years of age are mostly affected and have a worse prognosis (2,7,8,9). The frequency of these infections has increased in recent years, so healthcare personnel are increasingly encountering this dangerous disease.According to earlier data from the literature, this infection is caused by polymicrobial agents, both anaerobic and aerobic bacteria. However, some studies report the prevalence of monomicrobial NSTIs to be up to 60-80%, with the causative agents most often originating from the genitourinary and digestive tracts and the skin (2).Streptococcus pyogenes, a Gram-positive beta-hemolytic streptococcus of serological group A, is one of the most common organisms isolated in cases of NSTIs (1). If the infection is caused by Gram-negative microorganisms, the infections can take on more rapid and fulminant forms (7).