2021
DOI: 10.1093/neuros/nyab301
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Postoperative Oral Antibiotics and Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Tumors Study: A Multicenter, Prospective, Randomized, Double-Blinded, Placebo-Controlled Study

Abstract: BACKGROUND Postoperative prophylactic antibiotics are commonly used in pituitary surgery, but evidence supporting their use is lacking, which has implications for antibiotic stewardship. OBJECTIVE To evaluate whether receipt of postoperative oral antibiotics results in superior sinonasal quality of life (QOL) compared with placebo among patients who undergo endoscopic endonasal transsphenoidal pituitary surgery. … Show more

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Cited by 13 publications
(16 citation statements)
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“…The study demonstrated with level 3 evidence that there was no significant difference in gross total resection rate or volume of tumor resection between the two surgical techniques. However, it was not able to be completed due to the retirement of two participating surgeons on the microscopic resection arm and the failure to recruit replacements for them 13 .…”
Section: Personal Institutional and Multi-institutional Seriesmentioning
confidence: 99%
“…The study demonstrated with level 3 evidence that there was no significant difference in gross total resection rate or volume of tumor resection between the two surgical techniques. However, it was not able to be completed due to the retirement of two participating surgeons on the microscopic resection arm and the failure to recruit replacements for them 13 .…”
Section: Personal Institutional and Multi-institutional Seriesmentioning
confidence: 99%
“…At a PCE, the approach for a E-TSA is performed by an experienced skull base rhinologist. Their careful navigation of the nasal sinuses allows for improved outcomes in postoperative sinonasal morbidity ( 52 ). The middle turbinates are bilaterally lateralized to expose the sphenoid os.…”
Section: Operative Treatment Of Acromegalymentioning
confidence: 99%
“…The POET study, a recently published prospective, double-blinded, randomized controlled trial, evaluated the use of antibiotics after the endoscopic endonasal approach (EEA) for pituitary tumors specifically on sinonasal outcomes, excluding patients with Cushing's disease or those with planned nasoseptal flaps. 15 The study included 113 patients, with a single chosen antibiotic regimen consisting of cefdinir and trimethoprim-sulfamethoxazole.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…The authors did not find any significant benefit of using this postoperative antibiotic regimen compared with the placebo. 15 This investigation aims to bridge the gap in the literature regarding patient outcomes with a standardized assessment of patient and perioperative details from multiple institutions as a concerted multidisciplinary effort from the North American Skull Base Society (NASBS).…”
Section: Introductionmentioning
confidence: 99%
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