The success of endodontic treatment (ET) is largely dependent on the application of a strict protocol for disinfecting the root canal system and may be influenced by the number of visits but remains controversial in the literature. This review provides an overview of published studies comparing ET in single and multiple visits. A search was performed in the electronic databases such as PubMed, Cochrane Library, Science Direct, and Google Scholar from 2017 to 2022. Eligibility criteria were randomized clinical trials, reviews, and studies focusing on single- or multivisit techniques. Twenty-four articles were included. The main characteristics, including healing rates, success, and postoperative pain after ET, were extracted from the studies. The results of the studies included in this review showed that single- and multisession ET are similar in terms of healing rates and long-term complications, although both treatment approaches may be associated with short-term postoperative pain.