Postoperative pain relief after laparoscopic cholecystectomy: intraperitoneal lidocaine versus nalbuphine

Morsy, Khaled; Abdalla, Esam Eldin Mohamad

doi:10.4103/1687-7934.128402

Cited by 10 publications

(10 citation statements)

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“…Although both lidocaine and nalbuphine when used intraperitoneally produce postoperative analgesia, intraperitoneal lidocaine gives a better analgesic profile with fewer unwanted effects. [1] Khan et al, used both lidocaine and bupivacaine intraperitoneally during laparoscopic cholecystectomy for postoperative analgesia and concluded that bupivacaine and lidocaine are both safe and equally effective in decreasing postoperative pain after LC. [15] Some studies evaluated the efficacy of intraperitoneal and intravenous lidocaine on pain relief after LC and they reported significantly reduced postoperative pain and opioid consumption in LC patients, compared with control infusions.…”

Section: Discussionmentioning

confidence: 99%

“…:0038971221228; E-mail: marija_toleska@yahoo.com creased length of hospital stay. [1] Although pain after LC is less intense than after open cholecystectomy (OC), some patients still experience considerable discomfort and pain during the first 24 to 72 postoperative hours. [2] Postoperative pain remains the most prevalent complaint after laparoscopic cholecystectomy.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Toleska

Карталов

Кузмановска

et al. 2018

Prilozi

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Introduction: Patients undergoing laparoscopic cholecystectomy do experience postoperative pain, especially in the abdomen. Postoperative pain management remains a major challenge after laparoscopic procedures. Administration of intraperitoneal local anesthetic (IPLA) after surgery is used as a method of reducing postoperative pain. In this study, we evaluated the effect of intraperitoneal infiltration of local anesthetic (bupivacaine) for pain relief after laparoscopic cholecystectomy. Material and methods: In this prospective, controlled, and randomized study were included 50 patients aged 25-60 years (35 female and 15 male), scheduled to laparoscopic cholecystectomy with ASA classification 1 and 2. Patients were classified randomly into two groups: group A, which included 25 patients who received intraperitoneal instillation of bupivacaine 0.5% 20 ml; and group B, which included 25 patients who didn’t receive any intraperitoneal instillation. Postoperative pain was recorded using the visual analogue scale (VAS) for 24 hours after laparoscopic cholecystectomy. Results: There was no significant difference with respect to age, weight, and sex; duration of surgery; and anesthesia time. VAS scores at different time intervals were statistically significantly lower at all times in group A compared to group B. There were statistically significant differences in VAS scores between group A and group B at all postoperative time points - 1hr,4 hr,8 hr,12hr and 24hr (p < 0.00001). Conclusion: Intraperitoneal instillation of bupivacaine provides good analgesia in the postoperative period after laparoscopic cholecystectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Toleska

Карталов

Кузмановска

et al. 2018

Prilozi

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“…Laparoscopic cholecystectomy is widely performed, and it has replaced open cholecystectomy as the gold standard for cholelithiasis. Laparoscopic surgeries are favored over open surgeries because they have a number of advantages such as reduced postoperative pain and analgesic requirement, improved postoperative respiratory function, rapid return of gastrointestinal function, a reduced stress response to surgery and recovery time, less postoperative wound infection, and improved cosmetic appearance [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Postoperative Analgesic Effects of the Intraperitoneal Instillation of Bupivacaine Versus Normal Saline Following Laparoscopic Cholecystectomy

Vijayaraghavalu¹,

Sekar²

2021

Cureus

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BackgroundLaparoscopic cholecystectomy is widely performed, and postoperative pain is an important factor in patient morbidity during recovery. Various modalities for postoperative pain relief have been proposed, with varying levels of success such as intravenous or intramuscular non-steroidal anti-inflammatory drugs (NSAIDs) and opioids, infiltration at the incision site with local anesthetics, intraperitoneal infiltration of local anesthetics, intraperitoneal infiltration of local anesthetics with adjuvants, regional anesthesia techniques such as epidurals and nerve blocks. The study was aimed to evaluate the efficacy of intraperitoneal instillation of bupivacaine and normal saline on postoperative analgesia, postoperative nausea, and vomiting after laparoscopic cholecystectomy. MethodsThis prospective, controlled, and randomized study included 60 American Society of Anesthesiologists (ASA) I and ASA II patients, aged 18-50 years, who were scheduled for laparoscopic cholecystectomy under general anesthesia. The patients were classified randomly into two groups with an equal number of participants: Group B received intraperitoneal instillation of 30 ml of plain bupivacaine 0.5% and Group N received 30 ml of normal saline. Postoperative pain was recorded using the visual analog scale (VAS) for 24 hours after surgery. Postoperative shoulder pain, nausea, vomiting, and the time taken to request rescue analgesia were noted. ResultsPatients receiving intraperitoneal bupivacaine showed a significant reduction in postoperative pain for the first six hours postoperatively (P = 0.04); moreover, the time taken to request rescue analgesia requirement was prolonged (P = 0.04). Side effects, such as nausea and vomiting, were similar between the two groups (P = 0.1 and p = 0.09, respectively) while shoulder pain was significantly lower in the bupivacaine group (P = 0.04). ConclusionBupivacaine is effective in reducing postoperative pain, and it prolongs the requirement time for rescue analgesia. It also reduces the incidence of shoulder pain but does not decrease postoperative nausea and vomiting.

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“…Lately, the popularity of laparoscopic cholecystectomy has been on the rise, owing mainly to the facts that laparoscopic surgeries leave minimal surgical scars, only require short hospital stays, and promote early recovery [ 1 2 ]. However, visceral pain, port-site pain, and referred shoulder pain are occasionally reported in laparoscopic cholecystectomy patients [ 3 ]. Among multiple reports of attempts to reduce these types of pain, we chose to focus on the suggestion that intraperitoneal CO 2 concentrations are associated with postoperative pain, and that washing with normal saline to reduce the CO 2 concentrations significantly lowers the pain.…”

Section: Introductionmentioning

confidence: 99%

Effect of intraperitoneal CO₂ concentration on postoperative pain after laparoscopic cholecystectomy

et al. 2017

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PurposeThis study set out to identify the association between the intraperitoneal CO2 concentrations and postoperative pain by dividing the participants into a control group and 2 experimental groups receiving irrigation (1 L and 2 L), and directly measuring their intraperitoneal CO2 concentrations with a CO2 gas detector.MethodsA total of 101 patients, American Society of Anesthesiologists physical status classification I and II patients aged 18–65 years were enrolled in the study. Group 1 did not receive irrigation with normal saline, while groups 2 and 3 were administered irrigation with 1 L and 2 L of normal saline, respectively, after laparoscopic cholecystectomy. Intraperitoneal CO2 concentrations were measured with a CO2 gas detector through the port, and postoperative pain was assessed on a visual analogue scale at 6, 12, and 24 hours after surgery.ResultsThe intraperitoneal CO2 concentrations were 1,016.0 ± 960.3 ppm in group 1, 524.5 ± 383.2 ppm in group 2, and 362.2 ± 293.6 ppm in group 3, showing significantly lower concentrations in groups 2 and 3. Postoperative pain was significantly lower in group 3 at 6 hours after surgery, and in groups 2 and 3 at 12 hours after the surgery. However, there was no significant difference between the 3 groups in postoperative pain 24 hours after the surgery.ConclusionThis study found a causal relationship between the amount of normal saline used for irrigation and the intraperitoneal CO2 concentrations in that irrigation with normal saline reduces pain on the day of the surgery.

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Postoperative pain relief after laparoscopic cholecystectomy: intraperitoneal lidocaine versus nalbuphine

Cited by 10 publications

References 1 publication

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

A Comparative Study on the Postoperative Analgesic Effects of the Intraperitoneal Instillation of Bupivacaine Versus Normal Saline Following Laparoscopic Cholecystectomy

Effect of intraperitoneal CO₂ concentration on postoperative pain after laparoscopic cholecystectomy

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Postoperative pain relief after laparoscopic cholecystectomy: intraperitoneal lidocaine versus nalbuphine

Cited by 10 publications

References 1 publication

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

Efficacy of Intraperitoneal Bupivacaine on Pain Relief After Laparoscopic Cholecystectomy

A Comparative Study on the Postoperative Analgesic Effects of the Intraperitoneal Instillation of Bupivacaine Versus Normal Saline Following Laparoscopic Cholecystectomy

Effect of intraperitoneal CO2 concentration on postoperative pain after laparoscopic cholecystectomy

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Effect of intraperitoneal CO₂ concentration on postoperative pain after laparoscopic cholecystectomy