Postoperative Quality of Life after Total Gastrectomy Compared with Partial Gastrectomy: Longitudinal Evaluation by European Organization for Research and Treatment of Cancer-OG25 and STO22

Abstract

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. IntroductionGastric cancer is one of the most common malignancies worldwide, being the fourth most common cancer and the second leading cause of cancer-related death.1,2 In Korea, gastric cancer is the most common cancer in men (17.4%) and the fourth most common cancer in women (7.8%). odynophagia, choked when swallowing, weight loss, trouble eating with others, trouble swallowing saliva, trouble talking, and trouble with coughing. In this study, we evaluated the quality of life of gastrectomized patients using both, the OG25 and the STO22. Materials and Methods: A total of 138 patients with partial gastrectomy (PG) (distal gastrectomy=91; pylorus-preserving gastrectomy=47) and 44 patients with total gastrectomy (TG) were prospectively evaluated. Body weight and scores from the OG25 and STO22 were evaluated preoperatively and at 3 weeks, 3 months, and 6 months after surgery.Results: Patients with TG had significant weight loss compared to patients with PG. At 3 months, TG was associated with worse scores for dysphagia, eating, odynophagia, trouble eating with others, trouble with taste, and weight loss on the OG25. TG was also associated with dysphagia, eating restrictions, and anxiety on the STO22. The OG25 helped differentiate between the groups with respect to weight loss, odynophagia, choked when swallowing, and trouble eating with others. The OG25 scores changed over time and were significantly different. Conclusions:The OG25 is a more sensitive and useful scale than the STO22 for evaluating the quality of life of gastrectomized patients, especially those with total gastrectomy.

Targeted literature review of the global burden of gastric cancer

“…Among the identified studies, five were systematic literature reviews [63–67], nine were economic analyses [18, 20, 24, 26, 33, 37, 41, 42, 68], six were randomised controlled trials [69–73], one was an observational study [74], seven were prospective cohort or case-control studies [39, 75–80], seven were cross-sectional survey studies [81–87], four were retrospective studies [88–91] and one included a retrospective analysis and a prospective cross-sectional survey [92]. Only four studies used tools specific to GC or GEJC (GC module [STO22] and oesophago-gastric [OG25] modules of European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire [EORTC-QLQ]) to assess HRQoL [78, 80, 86, 87]. Among all studies reporting humanistic data ( n = 40), EORTC-QLQ-C30 was the most frequently used cancer-specific tool to assess HRQoL ( n = 13) [39, 64, 69–72, 74–78, 87, 91].…”

“…One study compared the accuracy of the oesophageal cancer-specific scale, EORTC-QLQ-OG25, with the GC-specific scale, EORTC-QLQ-STO22, for the assessment of the HRQoL in patients who underwent partial and total gastrectomy and found that the OG25 was more sensitive than the STO22. In this study, differences between the total and partial gastrectomy groups in weight loss, odynophagia, choking when swallowing and difficulty eating were identified only with the OG25 scale [80], and the OG25 scores for body image, dysphagia, odynophagia, pain and discomfort, anxiety and weight loss were worse after total compared with partial gastrectomy [80].…”

The pattern of postoperative quality of life following minimally invasive gastrectomy for gastric cancer: a prospective cohort from Korean multicenter robotic gastrectomy trial

“…The Korean version of the EORTC QLQ-C30 was validated in 2004 and has been widely used in postoperative patient surveys [ 8 ]. Various comparative studies have been conducted using these indicators for QOL [ 9 ].…”

Development and Validation of a Symptom-Focused Quality of Life Questionnaire (KOQUSS-40) for Gastric Cancer Patients after Gastrectomy

“…The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-STO22) and the Functional Assessment of Cancer Therapy-gastric (FACT-Ga) are commonly known instruments [3,4]. The EORTC QLQ-STO22 has been translated into many languages, including Korean, and has been used in many clinical trials and retrospective studies of Korean patients with gastric cancer [5][6][7][8].…”