Postoperative radiotherapy for radically resected N2 non-small-cell lung cancer (NSCLC): randomised clinical study 1988–1992

A Multicenter Retrospective Analysis of Survival Outcome Following Postoperative Chemoradiotherapy in Non–Small-Cell Lung Cancer Patients With N2 Nodal Disease

“…PORT is also acceptable for patients with N2 stage disease (8)(9)(10)(11)(12)(13); however, the effect of the therapeutic modality of adjuvant chemoradiotherapy remains unclear (8,20,21). Here, our study is to evaluate the addition of PORT to adjuvant chemotherapy focusing on patients with completely resected NSCLC with N2 node involvement.…”

“…These have included some clinical trials (5,10), a meta-analysis (8), and a regression tree analysis (9). An earlier study had demonstrated that PORT reduced local recurrence, but had no impact on distant metastases (11) and that patients with N1 and N2 disease had a poor outcome even with PORT (12)(13)(14).…”

A controlled study of postoperative radiotherapy for patients with completely resected nonsmall cell lung carcinoma

“…[25][26][27][28][29][30][31][32] Furthemore, a nonrandomized study of patients with resected N2 cancer 35 indicates a survival advantage for the group of 88 patients who received postoperative radiotherapy. Ten randomized trials [5][6][7][8][9][10][11][12][13][14][15] involving a total of 1711 evaluable patients failed to demonstrate an improve- 11 Lung Cancer Study Group, 10 and the Van Houtte trial 9 ) used doses of 40 Gy, 50 Gy, and 60 Gy, respectively. The total dose used in the current trial (60 Gy) was calculated at the central axis, at the midplane depth, or at the intersection point of multiple fields, as recommended by the International Commission of Radiation Units.…”

Postoperative Radiotherapy of NSCLC – Outcome after 3-D Treatment Planning

“…In many non-randomized and randomized trials there was a trend to a better local control with postoperative radiotherapy [2, 3, 5, 9-12, 15, 16]. Nevertheless randomized trials showed no benefit on overall survival [4,8,16]. In contrast some studies found an excess of intercurrent deaths among patients receiving postoperative radiotherapy [3,9,19].…”