Postoperative Recovery of Visual Function after Macula-Off Rhegmatogenous Retinal Detachment

Put, Mathijs A. J. van de; Croonen, Danna; Nolte, Ilja M.; Japing, Wouter J.; Hooymans, Johanna M. M.; Los, Leonoor I.

doi:10.1371/journal.pone.0099787

Cited by 22 publications

(20 citation statements)

References 27 publications

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“…In our study, the duration of macular detachment prior surgical intervention showed statistically significant correlation with post-operative logMAR BCVA (r=0.503, p 0.001). This result matches well with the studies done by Van de Put and colleagues [8] .…”

Section: Discussionsupporting

confidence: 93%

Correlation of Fundus Autofluorescence of the Macula with Visual Outcome after Successful Repair of Rhegmatogenous Retinal Detachment

Fadel¹,

Taha²,

Saeed

et al. 2018

The Medical Journal of Cairo University

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Background: Successful reattachment of the macula after RD is often associated with incomplete visual recovery. Even with a normal-appearing macula on examination, patients often experience visual impairment. Fundus autfluorescence has been used to investigate the morphological and functional changes occurring after RD repair following vitrectomy. Aim of the Work: To investigate the structure-function relationship of the macula, by correlating fundus autofluorescence and visual acuity following successful repair of rhegmatogenous retinal detachment. Material and Methods: Forty-five eyes underwent surgical repair of RRD followed by FAF imaging one and three months post-operative. FAF findings were correlated with postoperative BCVA. Results: Forty-five eyes achieved complete post-operative reattachment with 95.6% SOSR. Mean preoperative logMAR visual acuity showed significant difference with mean postoperative logMAR BCVA (p 0.001). The values of BCVA showed significant difference between eyes showing hyperautofluorescence on FAF imaging and eyes not showing hyperautofluorescence (p=0.015). Conclusion: Fundus autofluorescence is a recent noninvasive imaging modality that evaluates the function and health of the photoreceptor and the RPE layers showing great advantage in analyzing the macular function abnormality.

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Section: Discussionsupporting

confidence: 93%

Correlation of Fundus Autofluorescence of the Macula with Visual Outcome after Successful Repair of Rhegmatogenous Retinal Detachment

Fadel¹,

Taha²,

Saeed

et al. 2018

The Medical Journal of Cairo University

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“…The height of macular detachment was previously reported to influence visual recovery. Lower height of macular detachment correlates with better visual outcome 29,30 . This current study observed a consistent negative association between the macular detachment height and the final BCVA, but this trend was not statistically significant (regression coefficient: −0.466, p = 0.069).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotection with rasagiline in patients with macula-off retinal detachment: A randomized controlled pilot study

Framme

Menke

et al. 2020

Sci Rep

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We aimed to evaluate the neuroprotective efficacy of rasagiline in pseudophakic patients who had surgery for macula-off rhegmatogenous retinal detachment (RRD). This was a 6-month, prospective, randomized, double-blind, placebo-controlled pilot study. Patients presenting with acute macula-off RRD were recruited and randomized 1:1 to receive rasagiline 1 mg/day or placebo for 7 days. Bestcorrected visual acuity (BCVA) and optical coherence tomography were acquired 1 day before as well as 2 days, 3 weeks, 3 months and 6 months after surgery. We screened 26 patients with RRD whereof 23 were eventually included and randomized. The primary outcome was final BCVA. Secondary outcomes included central retinal thickness (CRT) and adverse events (AE). We evaluated photoreceptor cells (prc) recovery through morphological measurements. The baseline characteristics were comparable between groups. BCVA significantly improved in both groups (letters gained: rasagiline 61.5 ± 18.1 vs placebo 55.3 ± 29.2, p = 0.56), but no significant inter-group difference was found at any visit. CRT was stable 3 weeks after surgery onwards, with no inter-group difference. No treatment-emergent AE occurred. Significant prc restoration was observed from 3 weeks to 6 months after surgery, without inter-group difference at either visit. Ellipsoid zone integrity (β = 0.517, p = 0.008) and foveal bulge (β = 0.387, p = 0.038) were significant predictors of good final BCVA. In conclusion, perioperative oral treatment with rasagiline 1 mg/day for 7 days did not show significant benefits on visual or anatomical outcomes in macula-off RRD patients. Rhegmatogenous retinal detachment (RRD) refers to separation of the neurosensory retina from the retinal pigment epithelium (RPE) due to accumulation of subretinal fluid through one or more retinal breaks 1. Currently, surgical repair is the only available treatment. Foveal detachment (macula-off) occurs in 54.5% of all RRD patients and is a major factor influencing visual recovery after successful surgical repair 2. As a result of deprived metabolic supply from the RPE and choroidal vasculature, photoreceptor (prc) death is the ultimate cause of vision loss after RRD 3. This is particularly relevant in the macula, where the density of prc is the highest and maximal visual acuity is achieved. Arguably, visual acuity recovery is significantly limited due to prc loss. Apoptosis was believed to be the major cause involved in prc death. However, recent evidence demonstrated that non-apoptotic forms of cell death (autophagy and necrosis), mitochondrial outer membrane permeabilization and inflammation raised by the interaction between dying cells and phagocytes all play a role in prc death after RRD 4. Accordingly, strategies targeting these pathways may be effective in prc rescue after RRD. Rasagiline [N-propargyl-1-(R)-aminoindan] is a second-generation propargylamine pharmacophore that selectively and irreversibly inhibits monoamine oxidase B (MAO-B). It has been an approved drug for the treatment of Parkinson's d...

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“…Ce résultat paraît étonnant, étant donné l'urgence de la prise en charge : il faut en effet agir dans les 7 premiers jours de DDM pour obtenir les meilleurs résultats en termes d'acuité postopératoire [6][7][8][9][10], mais au-delà de 10 jours, la rapidité d'intervention ne paraît que peu influencer l'acuité finale [11,12].…”

Section: Discussionunclassified

“…On parle alors de Durée de décollement maculaire (DDM). De nombreuses études, rétrospectives, portant sur une centaine de patients chacune, amènent aux mêmes conclusions : aucune différence dans l'acuité finale postopé-ratoire n'est retrouvée si la prise en charge chirurgicale se déroule dans la première semaine de DDM [6][7][8][9][10]. Au-delà de 10 jours, le délai de prise en charge semblerait n'avoir que peu d'impact sur l'acuité finale [11,12].…”

Section: Introductionunclassified

Délai de prise en charge des patients atteints d’un premier épisode de décollement de rétine sur l’œil étudié en Midi-Pyrénées

Tolou

Mahieu-Durringer

Cassagne

et al. 2016

Journal Français d'Ophtalmologie

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Postoperative Recovery of Visual Function after Macula-Off Rhegmatogenous Retinal Detachment

Cited by 22 publications

References 27 publications

Correlation of Fundus Autofluorescence of the Macula with Visual Outcome after Successful Repair of Rhegmatogenous Retinal Detachment

Correlation of Fundus Autofluorescence of the Macula with Visual Outcome after Successful Repair of Rhegmatogenous Retinal Detachment

Neuroprotection with rasagiline in patients with macula-off retinal detachment: A randomized controlled pilot study

Délai de prise en charge des patients atteints d’un premier épisode de décollement de rétine sur l’œil étudié en Midi-Pyrénées

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