Postoperative Recurrence as an Associated Factor of Malignant Transformation of Oral Dysplastic Leukoplakia

Abstract

Purpose: To evaluate the clinically associated factors of malignant transformation in patients who received laser surgery for oral dysplastic leukoplakia. Procedures: The clinicopathological data of patients receiving laser surgery for dysplastic leukoplakia from 2002 to 2008 and HPV genomic DNA extracted from paraffin-embedded specimens were analyzed statistically. Results: A total 114 patients, 90 males and 24 females with an average age of 49.7 ± 12.2 years were enrolled. The follow-up period ranged from 1.07 to 7.43 years (mean 3.4 ± 1.3 years). Thirteen cases had malignant transformation (11.4%). Multiple-focus lesions, non-homogeneous leukoplakia, high-grade dysplasia and recurrence after laser treatment were significant factors in univariate analysis. Multivariate analysis showed that recurrence (relative risk = 9.40) was the independent prognostic factor for malignant transformation. Conclusions: Recurrence after laser treatment is an independent prognostic factor predicting malignant transformation of dysplastic oral leukoplakia.

Treatment results of CO2 laser vaporisation in a cohort of 35 patients with oral leukoplakia

“…Of the five patients with a progression to cancer in the present study, three patients had a previous recurrence after CO 2 laser vaporisation treatment. In another recent study, multivariate analysis showed that recurrence (relative risk = 9.40) was an independent prognostic factor for malignant transformation (Yang et al , ).…”

“…There were 5 of 35 patients of whom the OL progressed to an OSCC (14%), the annual malignant transformation rate being approximately 3%. In the literature, malignant transformation rates in patients treated with CO 2 laser vaporisation vary between 1.1% and 11.4% (Ishii et al, 2003(Ishii et al, , 2004van der Hem et al, 2005;Lim et al, 2010;Yang et al, 2010;Jerjes et al, 2012). However, in most studies, no annual malignant transformation rates have been calculated.…”

Clinical Appraisal of Endoscopy with Narrow-Band Imaging System in the Evaluation and Management of Homogeneous Oral Leukoplakia

“…Roed-Petersen [16] reported transformation rates of 1.3 and 9.1% in homogeneous leukoplakia and red-and white-appearing lesions, respectively. In our previous series studying malignant change of oral leukoplakia after carbon dioxide laser surgery, the risk of malignant transformation of nonhomogeneous leukoplakia was 6.87 times more than that of homogeneous lesions [17] . The clinical characteristics of this distinction between homogeneous and nonhomogeneous leukoplakia has been well demonstrated in previous studies [2,[14][15][16][17][18] .…”

Photodynamic therapy in the management of pre-malignant head and neck mucosal dysplasia and microinvasive carcinoma

“…Several other investigatoers have also reported on an association between MTR and high grade dysplasia (8, 9). In a recent multivariate analysis of 114 patients, Yang et al noted that lesions demonstrating a propensity for relapse after surgical resection were more at risk for relapse than the presence of high grade dysplasia (10). …”